Abstract:ACTH-secreting pituitary tumors mainly express somatostatin receptor 5 (SSTR5), since SSTR2 is downregulated by the elevated levels of glucocorticoids that characterize patients with Cushing’s disease (CD). SSTR5 is the molecular target of pasireotide, the only approved pituitary tumor-targeted drug for the treatment of CD. However, the molecular mechanisms that regulate SSTR5 are still poorly investigated. This review summarizes the experimental evidence supporting a role for the cytoskeleton actin-binding pr… Show more
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