Molecular mechanisms involved in doxorubicin-induced cardiotoxicity: A bibliometrics analysis by VOSviewer

Yarmohammadi, Fatemeh; Wallace Hayes, A.; Karimi, Gholamreza

doi:10.1007/s00210-023-02773-2

Cited by 5 publications

(3 citation statements)

References 59 publications

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“…The Web of Science Core Collection (WoSCC) was retrieved to identify the pertinent literature from inception to October 20, 2023, as previous studies [ 5,9,10 ] . By referring to a previously published article [ 11 ] , the search strategy was set as follows: (TS = (CP/CPPS OR CP‐CPPS OR chronic prostatitis/chronic pelvic pain syndrome OR chronic prostatitis with chronic pelvic pain syndrome OR chronic abacterial prostatitis)) AND TS = (animal OR rat OR mouse OR mice OR cell OR RWPE‐1 OR disease model).…”

Section: Methodsmentioning

confidence: 99%

Molecular mechanism and promising treatments of chronic prostatitis/chronic pelvic pain syndrome: An exploratory bibliometric analysis and literature review of preclinical studies

Lao,

Guan,

Wang

et al. 2023

UroPrecision

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BackgroundAs one of the most common diseases in urology, a large number of preclinical studies have been accumulated to explore the etiological mechanism and potential intervention of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).MethodsIn this study, we systematically evaluated the current status of preclinical research on CP/CPPS through bibliometrics analysis using VOSviewer and Citespace. Characteristics of publication such as year, country/region, institution, author, journal, citation, and keywords were analyzed. Based on the bibliometrics analysis results of keywords, we summarized the possible mechanisms and promising treatments for CP/CPPS narratively.ResultsAccording to the results of this study, the most common mechanisms involved in CP/CPPS were as follows: disturbed immune and inflammation mediators, immune cell dysfunction, oxidative stress, dysregulated signaling pathways, apoptosis, gut microbiota, and testosterone metabolism. Chinese Traditional Medicine and extracorporeal shock wave therapy have important potential in the treatment of CP/CPPS.ConclusionFurther translational studies targeting the above mechanisms and validating the objective efficacy of potential treatments indicated by preclinical studies in clinical patients are needed in the future.

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Section: Methodsmentioning

confidence: 99%

Molecular mechanism and promising treatments of chronic prostatitis/chronic pelvic pain syndrome: An exploratory bibliometric analysis and literature review of preclinical studies

Lao,

Guan,

Wang

et al. 2023

UroPrecision

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“…The prevalent mechanisms associated with DIC included oxidative stress, apoptosis, in ammation, autophagy, mitophagy, endoplasmic reticulum stress, pyroptosis, and ferroptosis. However, oxidative stress remained the primary molecular mechanism of DIC 6,7 .…”

Section: Introductionmentioning

confidence: 99%

Deciphering the Protective Effects of Carvacrol Against Doxorubicin-Induced Cardiotoxicity In Vitro and In Vivo

Retnosari,

Ghani,

Alkharji

et al. 2024

Preprint

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Doxorubicin (DOX), a widely used chemotherapy, extends its impact beyond cancer cells, notably affecting the heart, leading to substantial concerns about DOX-induced cardiotoxicity (DIC). However, subclinical DIC remains unresolved, necessitating advanced cardio-protection strategies in cancer therapy. Recent research explores carvacrol (CAR), a natural substance with antioxidant and anti-inflammatory properties, as a potential shield against DIC. However, further exploration is warranted, particularly concerning hypertrophy and cardiac fibrosis. This study investigated CAR’s potential cardioprotective properties against DIC in H9c2 cardiomyocytes and rats. Induction with DOX reduced cardiomyocyte viability, while pretreatment with 0.01 µg/mL CAR enhanced the viability of DOX-induced cardiomyocytes. Meanwhile, administration of DOX induced adverse effects in rats, causing decreased total heart weight and left ventricular mass, and lowered blood pressure. DOX also caused cardiac dysfunction, lipid peroxidation, hypertrophy, and fibrosis. In rat models, CAR pretreatment effectively mitigated DOX-induced reductions in blood pressure, hypertrophy, and cardiac fibrosis. However, the pretreatment kept the heart function, oxidative stress, and antioxidant enzymes unaltered. In conclusion, the results show that CAR could be an adjuvant to reduce DIC by ameliorating cardiac fibrosis and hypertrophy.

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“…Through the examination of countries, institutions, authors, keywords, and references, we can discern the research hotspots, research frontiers, and research content within the given field. Software tools, such as Citespace ( 12 ), VOSviewer ( 13 ), and Histcite ( 14 ), facilitate bibliometric analysis. Previous bibliometrics studies on acupuncture in cerebral infarction treatment mainly include “Visual bibliometric analysis of electroacupuncture research in stroke treatment: a 20-year overview” by Chun et al ( 15 ) and “Global trends and development of acupuncture for stroke: A review and bibliometric analysis” by Cheng and Yu ( 16 ).…”

Section: Introductionmentioning

confidence: 99%

A bibliometric analysis of acupuncture for cerebral infarction from 1993 to 2023

Zhao,

Huang,

et al. 2024

Front. Neurol.

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ObjectiveThis research aims to explore the trends and knowledge domain of acupuncture for cerebral infarction through bibliometrics.MethodsPublications related to acupuncture for cerebral infarction were retrieved from the Web of Science core collection database from 1993 to December 31, 2023. A domain knowledge graph was then constructed using VOSviewer, CiteSpace, GraphPad Prism, and Scimago Graphica.ResultsThe cumulative publication trend shows a steady increase over the years, with China being the most productive country. Notably, Europe exhibits significant close collaboration. Institutional cooperation is primarily observed among Chinese universities specializing in traditional Chinese medicine. Tao Jing is the most prolific author, with his highest number of publications is in “Stroke” journal, and Acupuncture Electro Therapeutics Research is the significant journal. Zhang SH is the most cited author, and Si QM is a prominent author in this field. Rehabilitation treatment after cerebral infarction emerges as a prevalent research focus, with nerve regeneration being a keyword. Long EZ's 1989 paper, published in the journal Stroke, holds significant importance. The prominent papers are Donnan et al. and Wu et al., which covers the following topics: “population-based study,” “Baihui Acupoint,” “memory deficits,” “neurotrophic factor,” and “randomized trial.”ConclusionThis bibliometric analysis of acupuncture for cerebral infarction offers insights into the Web of Science database, delineates a knowledge map of countries, authors, institutions, cited authors, keywords, cited references in the field of acupuncture for cerebral infarction, which has a momentous guiding significance for quickly and accurately positioning the key information in the field.

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Molecular mechanisms involved in doxorubicin-induced cardiotoxicity: A bibliometrics analysis by VOSviewer

Cited by 5 publications

References 59 publications

Molecular mechanism and promising treatments of chronic prostatitis/chronic pelvic pain syndrome: An exploratory bibliometric analysis and literature review of preclinical studies

Molecular mechanism and promising treatments of chronic prostatitis/chronic pelvic pain syndrome: An exploratory bibliometric analysis and literature review of preclinical studies

Deciphering the Protective Effects of Carvacrol Against Doxorubicin-Induced Cardiotoxicity In Vitro and In Vivo

A bibliometric analysis of acupuncture for cerebral infarction from 1993 to 2023

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