Molecular mechanisms in palatal rugae development

Trakanant, Supaluk; Nihara, Jun; Kawasaki, Maiko; Meguro, Fumiya; Yamada, Aki; Kawasaki, Keisuke; Saito, Isao; Maeda, Takeyasu; Ohazama, Atsushi

doi:10.1016/j.job.2019.12.002

Cited by 8 publications

(7 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed, loss-of-function mutations in Sostdc1, which encodes a secreted BMP anatagonist and WNT modulator, results in a failure of fusion associated with anterior ruga 4 and disorganized rugae morphology in the mouse 25,38 . Although human rugae morphology is more complex than that in the mouse, the fundamental mechanisms are likely to be conserved at the molecular level 28 . It is clear Control-group 16 (31%) 0 (0%) 35 (69%) 0 (0%) 0.47 Tooth agenesis-group 15 (29%) 0 (0%) 37 (71%) 0 (0%) 5…”

Section: Discussionmentioning

confidence: 99%

“…There is now some evidence that a reaction-diffusion mechanism is responsible for this initial patterning, with Fibroblast Growth Factor (FGF) signalling postulated to act as the activator X and the secreted morphogen Sonic Hedgehog (SHH) as the inhibitor Y 23 . However, other molecules also influence rugae development within this system, including members of the Bone Morphogenetic Protein (BMP) and WNT signalling families 26,27 , and the rugae morphology of a significant number of mouse mutants have now been described 28 .…”

mentioning

confidence: 99%

“…There is significant commonality in the molecular mechanisms that regulate formation of many embryonic structures and a host of signaling molecules, receptors and transcription factors are expressed in multiple regions of the developing craniofacial complex [29][30][31][32][33] . The palatal rugae therefore represent an excellent model to further investigate this commonality 28 . In recent years, a number of gene mutations have been identified in association with human forms of tooth agenesis, including MSX1 34 , PAX9 35 , WNT10A 36 and AXIN2 37 .…”

mentioning

confidence: 99%

See 2 more Smart Citations

Palatal rugae morphology is associated with variation in tooth number

Armstrong

Seehra

Andiappan

et al. 2020

Sci Rep

View full text Add to dashboard Cite

This observational study compared palatal rugae morphology in adolescent subjects with normal tooth number and tooth agenesis. Maxillary dental study casts were used to compare rugae number, length and shape. Each study group contained 60 subjects (30 females and 30 males) mean age 13.4 (SD, 1.55) in control and 13.56 (SD, 1.54) years in tooth agenesis groups (p = 0.576). Mean number of missing tooth units in the tooth agenesis group was 2.1. Mean number of primary rugae in the whole sample was 4.35 (SD, 0.98) on the right and 4.33 (SD, 0.92) on the left with no significant differences (p = 0.236 and p = 0.404, respectively). However, the number of secondary rugae on the left (p = 0.006) and fragmentary rugae on the right (p = 0.004) was significantly increased in the tooth agenesis group. The shape of left primary rugae 2 and 3 also differed between groups, tending towards a wavy pattern in the control group and curved in the tooth agenesis group (p = 0.012 and p = 0.004, respectively). In addition, primary rugae 3 was more convergent (p = 0.008) whilst left primary rugae 3 and 5 were orientated in an antero-posterior direction (p = 0.04 for both rugae) in the tooth agenesis group. Subgroup analysis also identified significant associations between patterns of tooth agenesis and rugae number, in addition to shape of primary rugae. The identification of significant differences in rugae pattern between subjects with normal tooth number and agenesis suggests potential commonality in signal pathway disruption during establishment of these structures.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Palatal rugae morphology is associated with variation in tooth number

Armstrong

Seehra

Andiappan

et al. 2020

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Palatal rugae are irregular and asymmetrical ridges on both sides of the median palatal raphe in the anterior part of the maxillary hard palate. The morphology of palatal rugae is individual-specific, and its development is strictly controlled by genes (Suhartono et al, 2016;Syed et al, 2016;Trakanant et al, 2020). They are stable and consistent in morphology throughout the life following completion of growth (Hermosilla et al, 2009;Selvamani et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Correlation Between the Anatomical Morphology of Palatal Rugae and Sex

Zhang

Shangguan

et al. 2022

Int. J. Morphol.

View full text Add to dashboard Cite

To investigate the correlation between the anatomical morphology of palatal rugae and sex. The study sample consisted of 120 students studying from Shanxi Medical University, of which 60 were females and 60 were males. The digital model of the palatal rugae was obtained by the 3 Shape TRIOS intraoral scanner. And the shapes of palatal rugae were recorded. Association between palatal rugae shape and sex were tested using Chi-square analysis. And logistic regression analysis (LRA) was carried out to calculate the accuracy of gender prediction using rugae shapes. There was a statistically significant difference between males and females in terms of the distribution of wavy and circular palate rugae. The use of logistic regression analysis obtained a sex predictive value of 65 % when all the rugae shapes were analyzed. Digital images of the palatal rugae morphology contribute to more accurate and convenient for data collection and transformation. It was found that rugae patterns can moderately identify the sex of the specific population when multivariate statistics such as LRA is applied. The palatal rugae morphology can be utilized as an assistant measure for sex identification.

show abstract

“…Development of palatal rugae occurs during embryogenesis via the interaction of epithelium and mesenchyme tissues. Their morphology remains stable during life 3 , 4 , however varies from individual to individual 5 – 7 . Thus it is generally accepted that the individual genetic background impacts on this variability 8 .…”

Section: Introductionmentioning

confidence: 99%

Genetic variants in bone morphogenetic proteins signaling pathway might be involved in palatal rugae phenotype in humans

Silva‐Sousa

Marañón‐Vásquez

Stuani

et al. 2021

Sci Rep

View full text Add to dashboard Cite

This study investigated, if genetic variants in BMP2, BMP4 and SMAD6 are associated with variations in the palatal rugae pattern in humans. Dental casts and genomic DNA from 75 patients were evaluated. Each patient was classified as follows: total amount of rugae; bilateral symmetry in the amount, length and shape of the palatal rugae; presence of secondary or fragmentary palatal rugae; presence of unifications; predominant shape; and predominant direction of the palatal rugae. The genetic variants in BMP2 (rs1005464 and rs235768), BMP4 (rs17563) and SMAD6 (rs2119261 and rs3934908) were genotyped. Genotype distribution was compared between palatal rugae patterns using the chi-square test (alpha = 0.05). The allele A was associated with the presence of secondary or fragmentary rugae for rs1005464 (OR = 2.5, 95%CI 1.1–6.3; p = 0.014). Secondary or fragmentary rugae were associated with the G allele in rs17563 (OR = 2.1, 95%CI 1.1–3.9; p = 0.017). rs17563 was also associated with rugae unification (p = 0.017 in the additive model). The predominant shape (wavy) was associated with rs2119261 (p = 0.023 in the additive model). The left–right symmetry of the length of primary rugae was associated with rs3934908 in the recessive model (OR = 3.6, 95%CI 1.2–11.7; p = 0.025). In conclusion, genetic variants in the BMP pathway impacted on palatal rugae pattern.

show abstract

Molecular mechanisms in palatal rugae development

Cited by 8 publications

References 44 publications

Palatal rugae morphology is associated with variation in tooth number

Palatal rugae morphology is associated with variation in tooth number

Correlation Between the Anatomical Morphology of Palatal Rugae and Sex

Genetic variants in bone morphogenetic proteins signaling pathway might be involved in palatal rugae phenotype in humans

Contact Info

Product

Resources

About