2013
DOI: 10.3389/fncel.2013.00244
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Molecular mechanisms driving homeostatic plasticity of neurotransmitter release

Abstract: Homeostatic plasticity is a process by which neurons adapt to the overall network activity to keep their firing rates in a reasonable range. At the cellular level this kind of plasticity comprises modulation of cellular excitability and tuning of synaptic strength. In this review we concentrate on presynaptic homeostatic plasticity controlling the efficacy of neurotransmitter release from presynaptic boutons. While morphological and electrophysiological approaches were successful to describe homeostatic plasti… Show more

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Cited by 48 publications
(46 citation statements)
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“…The changes that are reported here are anti-homeostatic; they do not act to dampen the excitability of neurons in the face of increased sensory-evoked activity. This contrasts to other studies that have investigated the effect of decreased neural activity that enhances release probability (Bacci et al 2001;Murthy et al 2001;Desai et al 2002;Yashiro and Philpot 2008;Lazarevic et al 2013); it may be that homeostatic adjustments in release are engaged by decreased but not increased sensory-evoked activity, and are not fully bidirectional.…”
Section: Sre Changes Presynaptic Properties: Enhancing Releasecontrasting
confidence: 47%
“…The changes that are reported here are anti-homeostatic; they do not act to dampen the excitability of neurons in the face of increased sensory-evoked activity. This contrasts to other studies that have investigated the effect of decreased neural activity that enhances release probability (Bacci et al 2001;Murthy et al 2001;Desai et al 2002;Yashiro and Philpot 2008;Lazarevic et al 2013); it may be that homeostatic adjustments in release are engaged by decreased but not increased sensory-evoked activity, and are not fully bidirectional.…”
Section: Sre Changes Presynaptic Properties: Enhancing Releasecontrasting
confidence: 47%
“…Conversely, prolonged exposure to elevated extracellular potassium concentration decreased RRP size and synaptic RIM levels (79). Thus, homeostatic signaling may affect synaptic RIM levels, as well as the levels of other presynaptic matrix-associated proteins (15). A current model suggests the activity-dependent modulation of the presynaptic ubiquitin proteasome system (15).…”
Section: Parallels With the Mechanisms Of Presynaptic Homeostasis At mentioning
confidence: 96%
“…Thus, homeostatic signaling may affect synaptic RIM levels, as well as the levels of other presynaptic matrix-associated proteins (15). A current model suggests the activity-dependent modulation of the presynaptic ubiquitin proteasome system (15).…”
Section: Parallels With the Mechanisms Of Presynaptic Homeostasis At mentioning
confidence: 98%
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“…The synaptic distribution of acidic shifts emphasizes that an alteration of synaptic transmission is the first step for the initiation and maintenance of ictal activity (Lazarevic et al, 2013). Release of SV protons into the synaptic cleft upon intense exocytosis has been recently proposed as a mechanism of protonergic transmission (Du et al, 2014;Wang et al, 2014).…”
Section: Discussionmentioning
confidence: 99%