Molecular mechanisms associated with quinolone resistance in Enterobacteriaceae: review and update

Azargun, Robab; Gholizadeh, Pourya; Sadeghi, Vahid; Hosainzadegan, Hasan; Tarhriz, Vahideh; Memar, Mohammad Yousef; Pormohammad, Ali; Eyvazi, Shirin

doi:10.1093/trstmh/traa041

Cited by 30 publications

(14 citation statements)

References 153 publications

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“…Data in Table 3 indicated that ciprofloxacin is the last barrier to eliminating antibiotic resistance Vibrio. Ciprofloxacin has stronger antibacterial activity than antibiotics of other groups such as amino acids, β-lactams, tetracyclines, and penicillins [17,18]. Ciprofloxacin inhibited bacteria growth through inactivation of the DNA gyrase, which further prevents chromosome replication [17].…”

Section: Discussionmentioning

confidence: 99%

The occurrence of antibiotic resistance Vibrio isolates from brackish water shrimp ponds in the coastal area in Thua Thien Hue, Vietnam

Tuan¹,

Khánh²,

Tien³

et al. 2022

J App Biol Biotech

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Shrimp culture has become an important industry which is accounting for approximately 18% of the total world's aquaculture economy. Asian and Latin America are major production areas whose economic value is estimated at USD 28 billion per year [1]. However, this highvalue industry has faced serious disease outbreaks, particularly caused by Vibrio bacteria, which have caused widespread losses to farmers. A certain Vibrio species can cause high mortality to shrimp such as V. parahaemolyticus, V. alginolyticus, V. harveyi, V. mimicus, or V. vulnificus. Vibrio bacteria are the major agent responsible for acute hepatopancreatic necrosis disease, shell disease, white gut disease, luminescent disease, red disease, and loose shell [2,3].Antibiotics were widely applied in aquaculture to control pathogenic bacterial infections including Vibrio species. The overuse of antibiotics

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Section: Discussionmentioning

confidence: 99%

The occurrence of antibiotic resistance Vibrio isolates from brackish water shrimp ponds in the coastal area in Thua Thien Hue, Vietnam

Tuan¹,

Khánh²,

Tien³

et al. 2022

J App Biol Biotech

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“…For example, for CIP resistance, all of the isolates were annotated to the fluoroquinolone-resistant efflux pump CRP and rsm A. The efflux pump is the principal mechanism of intrinsic and acquired AMR in clinical infections ( Azargun et al, 2020 ). It has substrate specificity and can excrete a variety of toxic compounds from bacterial cells, causing MDR.…”

Section: Discussionmentioning

confidence: 99%

Whole-genome sequencing-based prediction and analysis of antimicrobial resistance in Yersinia enterocolitica from Ningxia, China

et al. 2022

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Focusing on resistance trends and transmission patterns of pathogenic microorganisms is a major priority for national surveillance programs. The use of whole-genome sequencing for antimicrobial susceptibility testing (WGS-AST) is a powerful alternative to traditional microbiology laboratory methods. Yersinia enterocolitica antimicrobial resistance (AMR) in the Ningxia Hui Autonomous Region has yet to be described thoroughly in current studies. We assessed and monitored the development of Y. enterocolitica AMR in the Ningxia Hui Autonomous Region during 2007–2019 based on WGS-AST. Resistance genotypes were predicted based on WGS. Antimicrobial resistance testing using classical microbiology determined resistance to 13 antimicrobial agents in 189 Y. enterocolitica isolates from Ningxia. The highest resistance level was 97.88% for cefazolin, followed by ampicillin (AMP) (44.97%), ciprofloxacin (CIP) (25.40%), streptomycin (STR) (11.11%), and tetracycline (TET) (10.58%). Isolates emerged as chloramphenicol (CHL) and trimethoprim/sulfamethoxazole (SXT) resistant. The primary plasmid types were IncFII(Y) and ColRNAI. The TET, STR, and SXT resistance were mediated by the tetA, aph(6)-Id, aph(3″)-Ib, and sul2 genes located on the IncQ1 plasmid. The resistant strains were predominantly biotype 4/O:3/ST429 and the hosts were pigs and patients. The number of multidrug-resistant (MDR) strains was of concern, at 27.51%. At present, the prediction of antimicrobial resistance based on WGS requires a combination of phenotypes. From 2007 to 2019, Y. enterocolitica isolates from the Ningxia Hui Autonomous Region showed a relatively high rate of resistance to cefazolin (CZO) and some resistance to AMP, CIP, STR, and TET. CIP, SXT, and TET showed a relatively clear trend of increasing resistance. Plasmids carrying multiple drug resistance genes are an important mechanism for the spread of antimicrobial resistance. Isolates with low pathogenicity were more likely to present an AMR phenotype than non-pathogenic isolates.

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“…[22][23][24] In addition there is a co-existence with other antibiotics including Aminoglycosides and Fluoroquinolones. [25][26] These isolates exhibit decrease Ciprofloxacin susceptibility (DCS, MIC value 0.38mg/L) and Luminex based assay to detect mutations in quinolone resistant determining regions (QRDR) and plasmid mediated quinolone resistant gene (PMQR) reveal that DCSs was linked with the single mutation in residue ser83 of gyrA gene. This is one of the prominent genetic elements among salmonella typhi (S. Typhi) exhibiting DCS.…”

Section: Epidemiology Of Ctx-m -Lactamase-producing Bacteriamentioning

confidence: 99%

Drug Resistance due to Elaboration of Beta Lactamases and the Role of CTX-M in Enterobacteriaceae

Sohail¹,

Taj²,

Satti³

et al. 2022

J. Bahria Uni. Med. Dent. Coll.

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The Enterobacteriaceae family are the most common pathogens associated with hospital and community acquired infections worldwide. These bacteria are treated with broad spectrum antibiotics especially 3rd generation cephalosporins. Over the period of time due widespread and rigorous use of these medications, Enterobacteriaceae has developed antibiotic resistance (AMR). Among all, the most compelling antibiotic resistance mechanism is production of -lactamases enzymes by this microorganism. Over the course of time -lactamase has evolved more than 1300 distinct enzymes. Amongst these most deleterious is extended spectrum beta lactamases (ESBL). ESBL producing Enterbacteriacaeae are responsible for a high number of deaths worldwide. These enzymes are considered challenging as they are difficult to be identified in the laboratory wShich cause delay in diagnosis and administration of appropriate antimicrobial therapy. The coexistence of ESBL with other antibiotic resistance gene is another therapeutic challenge rendering empirical antibiotic treatment ineffective

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Molecular mechanisms associated with quinolone resistance in Enterobacteriaceae: review and update

Cited by 30 publications

References 153 publications

The occurrence of antibiotic resistance Vibrio isolates from brackish water shrimp ponds in the coastal area in Thua Thien Hue, Vietnam

The occurrence of antibiotic resistance Vibrio isolates from brackish water shrimp ponds in the coastal area in Thua Thien Hue, Vietnam

Whole-genome sequencing-based prediction and analysis of antimicrobial resistance in Yersinia enterocolitica from Ningxia, China

Drug Resistance due to Elaboration of Beta Lactamases and the Role of CTX-M in Enterobacteriaceae

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