Molecular Mechanisms Associated with Aging Kidneys and Future Perspectives

Abstract

The rapid growth of the elderly population is making the need for extensive and advanced information about age-related organ dysfunction a crucial research area. The kidney is one of the organs most affected by aging. Aged kidneys undergo functional decline, characterized by a reduction in kidney size, decreased glomerular filtration rate, alterations in renal blood flow, and increased inflammation and fibrosis. This review offers a foundation for understanding the functional and molecular mechanisms of aging kidneys and for selecting identifying appropriate targets for future treatments of age-related kidney issues.

Impact of treadmill on calcium homeostasis regulators (PTH, Calcitonin, and Vitamin D3) in D-galactose-induced osteoporosis in Rats

“…Oxidative stress can influence the redox state of proteins, including ion transporters in the kidney. Some sodium transporters are sensitive to changes in redox status, and alterations in their activity may affect sodium reabsorption [24,25,26]. The serum calcium concentration was significantly different in the D-gal treatment group compared to the C and D-gal + treadmill groups.…”