Molecular mechanism(s) of regulations of cancer stem cell in brain cancer propagation

Abstract

Brain tumors are most often diagnosed with solid neoplasms and are the primary reason for cancer-related deaths in both children and adults worldwide. With recent developments in the progression of novel targeted chemotherapies, the prognosis of malignant glioma remains dismal. However, the high recurrence rate and high mortality rate remain unresolved and are closely linked to the biological features of cancer stem cells (CSCs). Research on tumor biology has reached a new age with more understanding of CSC features. CSCs, a subpopulation of whole tumor cells, are now regarded as candidate therapeutic targets. Therefore, in the diagnosis and treatment of tumors, recognizing the biological properties of CSCs is of considerable significance.Here, we have discussed the concept of CSCs and their significant role in brain cancer growth and propagation.We have also discussed personalized therapeutic development and immunotherapies for brain cancer by specifically targeting CSCs.

Cancer stem cell fate determination: mito-nuclear communication

“…Cancer stem cells (CSCs) are a subpopulation of cancer cells with the potential for self-renewal and multidifferentiation and thus drive carcinogenesis, chemoresistance, recurrence and metastasis [1][2][3][4][5][6]. CSCs are also known as cancer stem cell-like cells [7], tumorigenic cells [8], tumor stem-like cells (TSCs) [9], and cancer-or tumor-initiating cells (CICs or TICs) [10,11].…”