Molecular Mechanism of STIL Coiled-Coil Domain Oligomerization
Mai Shamir,
Freddie J. O. Martin,
Derek N. Woolfson
et al.
Abstract:Coiled-coil domains (CCDs) play key roles in regulating both healthy cellular processes and the pathogenesis of various diseases by controlling protein self-association and protein–protein interactions. Here, we probe the mechanism of oligomerization of a peptide representing the CCD of the STIL protein, a tetrameric multi-domain protein that is over-expressed in several cancers and associated with metastatic spread. STIL tetramerization is mediated both by an intrinsically disordered domain (STIL400–700) and … Show more
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