Molecular mechanism of Phoebe bournei essential oils inhibiting the survival of Staphylococcus aureus and Bacillus cereus

Liu, Li; Li, Ji; Lai, Yong; Yang, Lili; He, Gongxiu; Zhang, Dangquan

doi:10.1016/j.indcrop.2023.117229

Cited by 2 publications

(1 citation statement)

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“…Natural food additives have recently received considerable attention due to their potential in alleviating UC with few adverse effects. , Essential oils, secondary metabolites of plants composed of various volatile organic components, such as alkanes, ester, alcohols, and aldehydes, are regarded as advantageous natural additives . Numerous studies have confirmed the diverse pharmacological properties of essential oils, including antibacterial, antiulcer, and anti-inflammatory effects. , For example, piperaceae essential oil not only displayed antioxidant, antibacterial, and anti-inflammatory characteristics but also relieved colitis in mice by alleviating intestinal inflammation .…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition and Antibacterial and Antiulcerative Colitis Activities of Essential Oil from Pruni Semen

Wang,

Lang,

et al. 2024

J. Agric. Food Chem.

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This study was sought to investigate the chemical composition and antibacterial and antiulcerative colitis (UC) effects of essential oil from Pruni Semen (PSEO). A GC-MS assay showed that the major compounds in PSEO were products of amygdalin hydrolysis, which possessed great antibacterial and anti-inflammatory potential. In vitro antibacterial experiments demonstrated that PSEO treatment inhibited activity of four kinds of intestinal pathogens probably by disrupting the cell wall. Further in vivo studies showed that PSEO administration significantly improved physiological indexes, attenuated histopathological characteristics, and inhibited proinflammatory cytokine production in dextran sulfate sodium (DSS)-induced UC mice. Network pharmacology and molecular docking results predicted that PSEO might prevent UC via regulating the PI3K/AKT pathway. Western blotting and immunofluorescence assays were further conducted for verification, and the results evidenced that PSEO intervention significantly regulated the PI3K/AKT pathway and the expression of its downstream proteins in DSS-induced mice. PSEO might provide a new dietary strategy for UC treatment.

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