Molecular mechanism of lncRNAs in pathogenesis and diagnosis of auto-immune diseases, with a special focus on lncRNA-based therapeutic approaches

Mehmandar-Oskuie, Amirreza; Jahankhani, Kasra; Rostamlou, Arman; Mardafkan, Nasibeh; Karamali, Negin; Razavi, Zahra Sadat; Mardi, Amirhossein

doi:10.1016/j.lfs.2023.122322

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2024

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“…Depending on their cellular localization, lncRNAs can act as transcriptional enhancers or translational regulators for different cellular processes, such as viability [ 2 , 3 ], cell cycle [ 4 , 5 ] and differentiation [ 6 ]. LncRNAs have also been associated with the development and progression of various pathological conditions, such as cancer [ 7 , 8 ] and autoimmune disorders [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

LncRNAs, nuclear architecture and the immune response

Montano,

Flores-Arenas,

Carpenter

2024

Nucleus

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Long noncoding RNAs (LncRNAs) are key regulators of gene expression and can mediate their effects in both the nucleus and cytoplasm. Some of the best-characterized lncRNAs are localized within the nucleus, where they modulate the nuclear architecture and influence gene expression. In this review, we discuss the role of lncRNAs in nuclear architecture in the context of their gene regulatory functions in innate immunity. Here, we discuss various approaches to functionally characterize nuclear-localized lncRNAs and the challenges faced in the field.

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