Molecular Mechanism and Biomechanics of the Diabetic Foot: The Road to Foot Ulceration and Healing

Zubair, Mohammad; Fatima, Farha

doi:10.1007/978-981-15-7639-3_6

Cited by 2 publications

(2 citation statements)

References 78 publications

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“…This tool was developed by the investigator in simple Arabic language based on reviewing the related literatures (8,9) . It included three parts: A) Socio-demographic characteristics of patients: It was used to assess the patient's demographic characteristics including age, gender, marital status, education level, occupation status, monthly income and residence; B) Medical history of patients: It was used to assess patient's medical and family history including the following: duration of disease, type of DM, type of diabetic medication, period of hospitalization, main cause of current hospialization adimision, amputation site, complication at amputation site, history of chronic diseases, previous amputation surgery, family history of DM and amputation; C) Knowledge assessment questionnaire: This tool was adapted from Zubair et al (10) to assess the knowledge of patients regarding diabetes mellitus (7 items), diabetic foot care (21 items), and diabetic foot amputation (13 items).…”

Section: Methodsmentioning

confidence: 99%

Health Related Quality of Life for Patients with Diabetic Foot Amputation

Ahmed¹,

Mahmoud²,

Saad³

2023

The Egyptian Journal of Hospital Medicine

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Background: In the latter stages of many illnesses, such as diabetes mellitus, limb amputation is a life-altering treatment that has social, psychological, and functional repercussions that lower the patient's quality of life. Objective: The current study aimed to assess the health-related quality of life for patients with diabetic foot amputation. Patients and methods: A descriptive exploratory study was conducted at the Outpatient Clinic affiliated to Beni-Suef University Hospital. A total of 70 diabetic patients, 3 to 18 after amputation operation for follow up, were recruited using a purposive sample. Data of participants were collected using two tools; (I): Structured interviewing questionnaire, it included three parts; socio-demographic characteristics of patients, medical history of patients and knowledge assessment questionnaire. (II) World Health Organization quality of life SF36 questionnaire. Results: About 51.4% of studied patients were in the age group 50 -<60 years, 58.6% of them had unsatisfactory total knowledge level regarding diabetic foot and amputation, and 60% of them had unhealthy or poor quality of life. There was no statistically significant correlation between total knowledge and total quality of life regarding diabetic foot amputation. Conclusion: Developing and implementing an educational programme for patients with diabetic foot amputation for improvement of their quality of life is strongly and urgently needed.

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Section: Methodsmentioning

confidence: 99%

Health Related Quality of Life for Patients with Diabetic Foot Amputation

Ahmed¹,

Mahmoud²,

Saad³

2023

The Egyptian Journal of Hospital Medicine

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“…In several complications of diabetes, inflammation, neuropathy, and vascular disease are the main factors of delayed wound healing. Moreover, most diabetic patients develop diabetic neuropathy, loss of lower limb pain, vascular ischemia, and various metabolic abnormalities, leading to unknown wounds until serious infection [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Topical Application of Chinese Formula Yeliangen Promotes Wound Healing in Streptozotocin-Induced Diabetic Rats

Al-Romaima

Guan

Qin

et al. 2022

Journal of Diabetes Research

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Diabetic wound is one of the most severe complications of diabetes mellitus (DM). Despite the associated risks of wound healing impairment in diabetes, treatment strategies remain limited. Yeliangen (YLG) is a Chinese formulation mainly composed of the rhizome of Coptis chinensis, the root of Isatis tinctoria, and the leaf of Isatis indigotica. We investigated the wound healing effects of YLG in type 2 diabetic (T2DM) rats, which were induced by intraperitoneal administration of streptozotocin after a high-fat diet for four weeks. 3 × 3 c m 2 full-thickness excisional wounds were created on the dorsal surface of rats and then divided to control (DC), negative (DPJ), positive (DPC), and YLG-treated (DYLG) groups. Rat’s wounds were treated twice daily for 21 days. Wound area and wound contraction were detected on days 0, 3, 7, 14, and 21. Histopathological examinations were performed by H&E staining and immunohistochemistry (IHC). The biochemical parameters, mRNAs, and protein expressions were analyzed through enzyme-linked immunoassays (ELISA), qPCR, and western blot, respectively. Compared with other groups, the histological changes of wound tissue in the DYLG group were improved, and the expressions of CD31, eNOS, and PCNA were significantly upregulated. Besides, YLG significantly reduced the inflammatory factors’ expressions of TNF-α, NF-κB, MMP-9, and IL-1B on days 7, 14, and 21 postwounding. Moreover, YLG induced angiogenesis and neovascularization by significantly increasing the levels of VEGF, TGF-β1, EGF, PDGF, and SDF-1α on days 3, 7, and 14. In conclusion, YLG improved wound healing by reducing inflammation and increasing angiogenesis which may provide an alternative and effective approach for diabetic wound therapy.

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Molecular Mechanism and Biomechanics of the Diabetic Foot: The Road to Foot Ulceration and Healing

Cited by 2 publications

References 78 publications

Health Related Quality of Life for Patients with Diabetic Foot Amputation

Health Related Quality of Life for Patients with Diabetic Foot Amputation

Topical Application of Chinese Formula Yeliangen Promotes Wound Healing in Streptozotocin-Induced Diabetic Rats

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