Molecular mass and antitumor activities of sulfated derivatives of α-glucan from Poria cocos mycelia

Modificação química da pectina do melão caipira (Cucumis melo var. Acidulus)

“…15,16 (1) onde: GS = Grau de Sulfatação da pectina; 162 = massa molar da unidade monomérica de ácido galacturônico (C 6 H 10 O 5 ); 80 = massa molar do grupo SO 3 ; 32 = massa molar do átomo enxofre (S)…”

Effect of Sulfated Modification on the Molecular Characteristics and Biological Activities of Polysaccharides fromHypsizigus marmoreus

“…Lin et al 13) have also reported considerable degradation of the polysaccharide during sulfation when using chlorosulfonic acid-pyridine and observed a rapid decrease in M w with increasing reaction temperature from 80 to 100 C. The radius of gyration (R g ) was also calculated to estimate the approximate size of the native and sulfated polysaccharides ( Table 2). R g values for the sulfated polysaccharides were significantly higher than that of the native polysaccharide, despite their lower M w , suggesting that the sulfated polysaccharides may have been in a more extended chain conformation than the native polysaccharide.…”

“…The data also indicate that extensive substitution was not necessary to obtain the greatest immunomodulatory activity; therefore, substitution by sulfated groups on the polysaccharide could be performed under relatively mild conditions such as a reaction temperature lower than 50 C, reaction time of less than 6 h and a sample to STMA ratio of 1:1. Polysaccharides and their sulfated derivatives have attracted considerable attention in recent years because of their diverse biological activities 8,13,[35][36][37] and are regarded as biological response modifiers (BRM) or immunomodulators. Sulfated polysaccharides could prevent carcinogenesis by their direct cytotoxicity toward tumor cells or by inducing macrophages to produce cytotoxic substances.…”

“…12) According to Lin et al, 13) the sulfated modification of polysaccharides from Poria cocos mycelia significantly increased the antitumorial activities toward Sarcoma 180 tumor cells that had been treated both in vitro and in vivo when compared to the native polysaccharide. Zhang et al 14) have also reported that the splenocyte-activating activity was significantly enhanced by treating with sulfated polysaccharide derivatives originating from Chinese persimmon fruit.…”

ASSESSING BIOLOGICAL ACTIVITY OF CARBOXYMETHYLATED DERIVATIVES OF Α -(1 → 3)-Glucans ISOLATED FROM FRUITING BODIES OF CULTIVATED PLEUROTUS SPECIES

“…Jak wykazano we wcześniejszych badaniach, karboksymetylowana pochodna α-(1→3)-glukanu wyizolowanego z owocników P. ostreatus miała wysoką aktywność cytotoksyczną i antyproliferacyjną w stosunku do komórek nowotworowych linii HeLa [19]. Zwiększoną aktywność przeciwnowotworową i immunomodulacyjną wykazywały również α-(1→3)-glukany izolowane z Poria cocos [10], Lentinus edodes [23], Amanita muscaria [21] oraz Ramalina celastri [16] poddane modyfikacjom typu: karboksymetylacja, sulfonowanie, aminopropylacja lub hydroksyetylowanie.…”