Molecular Mapping of the Major Epitopes of BP180 Recognized by Herpes Gestationis Autoantibodies

Lin, Mong Shang; Gharia, Manish; Fu, Chang Ling; Olague-Marchan, Mónica; Hacker, Mary K.; Harman, K. E.; Bhogal, B.S.; Black, Martin M.; Díaz, Luis A.; Giudice, George J.

doi:10.1006/clim.1999.4756

Cited by 49 publications

(32 citation statements)

References 28 publications

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“…3). Within this membraneproximal stretch of 76 amino acids, PG autoantibodies bind to five well-defined epitopes (designated NC16A1, NC16A2, NC16A2.5, NC16A3 and NC16A5) 42,43 (Fig. 4).…”

Section: Immunopathology and Diagnosismentioning

confidence: 99%

Pemphigoid gestationis: new insights into the pathogenesis lead to novel diagnostic tools

Shimanovich

2002

BJOG: An International Journal of Obstetrics and Gynaecology

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“…3). Within this membraneproximal stretch of 76 amino acids, PG autoantibodies bind to five well-defined epitopes (designated NC16A1, NC16A2, NC16A2.5, NC16A3 and NC16A5) 42,43 (Fig. 4).…”

Section: Immunopathology and Diagnosismentioning

confidence: 99%

Pemphigoid gestationis: new insights into the pathogenesis lead to novel diagnostic tools

Shimanovich

2002

BJOG: An International Journal of Obstetrics and Gynaecology

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“…The PG antigen in 180 kD antigen (BPAG2) is present in the hemidesmosomes of the basement membrane [9]. Antibasement membrane zone (BMZ) antibodies, mainly IgG1 are pathogenic [10]. The antigenic trigger for their production is probably paternally derived since PG can occur in association with trophoblastic tumors hydatiform mole, and choriocarcinoma in which the chromosomes are paternally derived [11].…”

Section: Discussionmentioning

confidence: 99%

Pemphigoid Gestationis (Herpes Gestationis)

Samson

Thomas

Philip

et al. 2013

J Obstet Gynecol India

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“…In BP and PG, autoantibodies are directed to hemidesmosomes that are cellular structures involved in anchoring keratinocytes to the basement membrane, and the major autoantigen is BP180, a transmembrane protein belonging to the collagen family, also known as collagen XVII. The extracellular domain of BP180 contains 15 collagen domains, interrupted by 16 non-collagen (NC) sequences, and the membrane-proximal NC domain NC16A contains multiple epitopes recognised by sera from patients with BP [109][110][111][112].…”

Section: The Pemphigoid Syndromesmentioning

confidence: 99%

The Role of Pathogenic Autoantibodies in Autoimmunity

Rowley

Whittingham

2015

Antibodies

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Abstract:The serological presence of autoantibodies is diagnostic of autoimmunity, and these autoantibodies may be present for many years before the presentation of autoimmune disease (AID). Although a pathogenic role has been demonstrated for various autoantibodies reactive with cell surface and extracellular autoantigens, studies using monoclonal antibodies (mAb) show not all antibodies in the polyclonal response are pathogenic. Differences depend on Fab-mediated diversity in epitope specificity, Fc-mediated effects based on immunoglobulin (Ig) class and subclass, activation of complement, and the milieu in which the reaction occurs. These autoantibodies often occur in organ-specific AID and this review illustrates their pathogenic and highly specific effects. The role of autoantibodies associated with intracellular antigens is less clear. In vitro they may inhibit or adversely affect well-defined intracellular biochemical pathways, yet, in vivo they are separated from their autoantigens by multiple cellular barriers. Recent evidence that Ig can traverse cell membranes, interact with intracellular proteins, and induce apoptosis has provided new evidence for a pathogenic role for such autoantibodies. An understanding of how autoantibodies behave in the polyclonal response and their role in pathogenesis of AID may help identify populations of culprit B-cells and selection of treatments that suppress or eliminate them.

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Molecular Mapping of the Major Epitopes of BP180 Recognized by Herpes Gestationis Autoantibodies

Cited by 49 publications

References 28 publications

Pemphigoid gestationis: new insights into the pathogenesis lead to novel diagnostic tools

Pemphigoid gestationis: new insights into the pathogenesis lead to novel diagnostic tools

Pemphigoid Gestationis (Herpes Gestationis)

The Role of Pathogenic Autoantibodies in Autoimmunity

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