Molecular Magnetic Resonance Imaging Using a Redox-Active Iron Complex

Wang, Huan; Jordan, Veronica Clavijo; Ramsay, Ian; Sojoodi, Mozhdeh; Fuchs, Bryan C.; Tanabe, Kenneth K.; Caravan, Peter; Gale, Eric M.

doi:10.1021/jacs.9b00603

Cited by 104 publications

(150 citation statements)

References 80 publications

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“…10,11 Iron (Fe 3+ ) complex can be also used as a contrast agent instead of Gd 3+ because Fe 3+ is also a paramagnetic material having less toxicity. [12][13][14] The iron-tannic nanoparticles (Fe-TA NPs), which have been produced by the interaction of Fe 3+ and tannic acid (TA), have shown benecial properties. Examples of their benecial properties are that they have small size, high MRI relaxivity, high stability, good water solubility, and demonstrate high uptake efficiency in tumor cells with capability of being responsive to abnormal microenvironments.…”

Section: Introductionmentioning

confidence: 99%

MRI contrast enhancement of liver pre-neoplasia using iron–tannic nanoparticles

et al. 2020

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Section: Introductionmentioning

confidence: 99%

MRI contrast enhancement of liver pre-neoplasia using iron–tannic nanoparticles

et al. 2020

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“…There are many possibilities for this result: (1) During the culture period of PBMCs with IronQ, the useful cells of IronQ in proliferation and differentiation processes and the interactions between IronQ and biomolecules or metabolites in the cells may have resulted in the conformation and/or oxidation state of IronQ changes. These may include IronQ metabolite products, the self-aggregation of IronQ, and the high-spin Iron (III)-quercetin complex changing to a low-spin Iron (II)-quercetin complex involved in reducing T1 relaxivity [ 108 ]. Thus, a stability test and pharmacokinetics study of IronQ are necessary to achieve the next goal of improving labeling efficiency and MRI tracking.…”

Section: Resultsmentioning

confidence: 99%

Iron (III)-Quercetin Complex: Synthesis, Physicochemical Characterization, and MRI Cell Tracking toward Potential Applications in Regenerative Medicine

Papan

Kantapan

Sangthong

et al. 2020

Contrast Media & Molecular Imaging

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In cell therapy, contrast agents T1 and T2 are both needed for the labeling and tracking of transplanted stem cells over extended periods of time through magnetic resonance imaging (MRI). Importantly, the metal-quercetin complex via coordination chemistry has been studied extensively for biomedical applications, such as anticancer therapies and imaging probes. Herein, we report on the synthesis, characterization, and labeling of the iron (III)-quercetin complex, “IronQ,” in circulating proangiogenic cells (CACs) and also explore tracking via the use of a clinical 1.5 Tesla (T) MRI scanner. Moreover, IronQ had a paramagnetic T1 positive contrast agent property with a saturation magnetization of 0.155 emu/g at 1.0 T and longitudinal relaxivity (r1) values of 2.29 and 3.70 mM−1s−1 at 1.5 T for water and human plasma, respectively. Surprisingly, IronQ was able to promote CAC growth in conventional cell culture systems without the addition of specific growth factors. Increasing dosages of IronQ from 0 to 200 μg/mL led to higher CAC uptake, and maximum labeling time was achieved in 10 days. The accumulated IronQ in CACs was measured by two methodologies, an inductively coupled plasma optical emission spectrometry (ICP-EOS) and T1-weighted MRI. In our research, we confirmed that IronQ has excellent dual functions with the use of an imaging probe for MRI. IronQ can also act as a stimulating agent by favoring circulating proangiogenic cell differentiation. Optimistically, IronQ is considered beneficial for alternative labeling and in the tracking of circulation proangiogenic cells and/or other stem cells in applications of cell therapy through noninvasive magnetic resonance imaging in both preclinical and clinical settings.

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“…143,144 Recently a redox-active iron complex, Fe-PyC3A, was shown to detect tissue inflammation and in vivo Fe-PyC3A-induced signal enhancement correlated strongly with ex vivo quantitation of MPO activity. 145…”

Section: Key Pointmentioning

confidence: 99%

Advances in functional and molecular MRI technologies in chronic liver diseases

Zhou

Catalano

Caravan

2020

Journal of Hepatology

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MRI has emerged as the most comprehensive non-invasive diagnostic tool for liver diseases. In recent years, the value of MRI in hepatology has been significantly enhanced by a wide range of contrast agents, both clinically available and under development, that add functional information to anatomically detailed morphological images, or increase the distinction between normal and pathological tissues by targeting molecular and cellular events. Several classes of contrast agents are available for contrastenhanced hepatic MRI, including i) conventional non-specific extracellular fluid contrast agents for assessing tissue perfusion; ii) hepatobiliary-specific contrast agents that are taken up by functioning hepatocytes and excreted through the biliary system for evaluating hepatobiliary function; iii) superparamagnetic iron oxide particles that accumulate in Kupffer cells; and iv) novel molecular contrast agents that are biochemically targeted to specific molecular/cellular processes for staging liver diseases or detecting treatment responses. The use of different functional and molecular MRI methods enables the non-invasive assessment of disease burden, progression, and treatment response in a variety of liver diseases. A high diagnostic performance can be achieved with MRI by combining imaging biomarkers.

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Molecular Magnetic Resonance Imaging Using a Redox-Active Iron Complex

Cited by 104 publications

References 80 publications

MRI contrast enhancement of liver pre-neoplasia using iron–tannic nanoparticles

MRI contrast enhancement of liver pre-neoplasia using iron–tannic nanoparticles

Iron (III)-Quercetin Complex: Synthesis, Physicochemical Characterization, and MRI Cell Tracking toward Potential Applications in Regenerative Medicine

Advances in functional and molecular MRI technologies in chronic liver diseases

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