Molecular logic gets loaded

Silva, de

doi:10.1038/nmat1301

Cited by 89 publications

(42 citation statements)

References 13 publications

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“…[65][66][67][68][69][70][71][72][73][74] During the past years modules of biological systems have also been described by using Boolean logic, or have been intentionally manipulated to perform such operations. [35,69,[75][76][77][78][79][80][81][82][83][84][85][86][87][88][89][90] We investigate here replicating molecular networks consisting of three templates [represented by n = 3 in Eq.…”

Section: Resultsmentioning

confidence: 99%

Systems Chemistry: Logic Gates, Arithmetic Units, and Network Motifs in Small Networks

Wagner

Ashkenasy

2009

Chemistry A European J

106

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A mixture of molecules can be regarded as a network if all the molecular components participate in some kind of interaction with other molecules--either physical or functional interactions. Template-assisted ligation reactions that direct replication processes can serve as the functional elements that connect two members of a chemical network. In such a process, the template does not necessarily catalyze its own formation, but rather the formation of another molecule, which in turn can operate as a template for reactions within the network medium. It was postulated that even networks made up of small numbers of molecules possess a wealth of molecular information sufficient to perform rather complex behavior. To probe this assumption, we have constructed virtual arrays consisting of three replicating molecules, in which dimer templates are capable of catalyzing reactants to form additional templates. By using realistic parameters from peptides or DNA replication experiments, we simulate the construction of various functional motifs within the networks. Specifically, we have designed and implemented each of the three-element Boolean logic gates, and show how these networks are assembled from four basic "building blocks". We also show how the catalytic pathways can be wired together to perform more complex arithmetic units and network motifs, such as the half adder and half subtractor computational modules, and the coherent feed-forward loop network motifs under different sets of parameters. As in previous studies of chemical networks, some of the systems described display behavior that would be difficult to predict without the numerical simulations. Furthermore, the simulations reveal trends and characteristics that should be useful as "recipes" for future design of experimental functional motifs and for potential integration into modular circuits and molecular computation devices.

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Section: Resultsmentioning

confidence: 99%

Systems Chemistry: Logic Gates, Arithmetic Units, and Network Motifs in Small Networks

Wagner

Ashkenasy

2009

Chemistry A European J

106

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“…Photocurrent action spectra generated in the CdS nanoparticle/dsDNA systems: a) Anodic photocurrents generated in the absence (1) and in the presence (2) of the doxorubicin intercalator (3). The data were obtained at the applied potential E = 0 V and in the presence of TEOA (20 mm).…”

Section: Methodsmentioning

confidence: 99%

“…The use of molecular [1][2][3][4] and biomolecular [5][6][7] assemblies that perform logic gate functions has attracted substantial interest directed toward information storage and processing. In these efforts, nanoparticles have been employed to switch the conductivity properties across interfaces.…”

Section: In Memory Of Chava Lifshitzmentioning

confidence: 99%

Electrochemical Control of the Photocurrent Direction in Intercalated DNA/CdS Nanoparticle Systems

et al. 2005

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“…[15] Zum Beispiel nutzt das En- [16] Des Weiteren konnte gezeigt werden, dass Fluorescein als molekularer Taschenrechner mit Reset-Funktion genutzt werden kann. [17] Genauso wichtig wie das Prozessieren von Information ist die Entwicklung geeigneter Methoden zum Informationstransport und zur Signalkodierung.…”

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Messen auf molekularer Ebene – Chemie an der Schnittstelle zur Informationstechnologie

Trapp

2008

Angewandte Chemie

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Eine hohe räumliche Auflösung für die Bestimmung positionsabhängiger Protonenkonzentrationen, die durch andere Messmethoden kaum zugänglich sind, liefern Multiplexing‐Fluoreszenzsensoren in micellaren Systemen. Solche Systeme, gekoppelt mit logischen Elementen, ahmen biologische Systeme nach und können als molekulare Detektionscomputer verwendet werden. Das Bild zeigt eine Micelle mit positionsselektiven Sensoren, deren Fluoreszenz Informationen über die chemische Umgebung liefert.

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Molecular logic gets loaded

Cited by 89 publications

References 13 publications

Systems Chemistry: Logic Gates, Arithmetic Units, and Network Motifs in Small Networks

Systems Chemistry: Logic Gates, Arithmetic Units, and Network Motifs in Small Networks

Electrochemical Control of the Photocurrent Direction in Intercalated DNA/CdS Nanoparticle Systems

Messen auf molekularer Ebene – Chemie an der Schnittstelle zur Informationstechnologie

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