Molecular linkage of hantavirus pulmonary syndrome to the white-footed mouse, Peromyscus leucopus: genetic characterization of the M genome of New York virus

Hjelle, Brian; Lee, S W; Song, Wanmin; Torrez‐Martinez, Norah; Song, Jin Won; Yanagihara, Richard; Gavrilovskaya, Irina N.; Mackow, Erich R.

doi:10.1128/jvi.69.12.8137-8141.1995

Cited by 98 publications

(40 citation statements)

References 37 publications

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“…The two sequences were 98.2% identical within the region studied. A similar level of identity (99%) has been reported for the complete M sequences determined with specimens from a hantavirus pulmonary syndrome (HPS) patient and a wild-type New York hantavirus from a white-footed mouse in the northeastern United States (19). Nichol et al (28) have reported 99 to 100% identity between partial Msegment sequences of Sin Nombre hantavirus (SN) derived from three HPS patients and those derived from deer mice trapped at or near the patients' residences in the Four Corners region of the southwestern United States.…”

Section: Discussionsupporting

confidence: 66%

Puumala hantavirus genome in patients with nephropathia epidemica: correlation of PCR positivity with HLA haplotype and link to viral sequences in local rodents

et al. 1997

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Reverse transcription-PCR was used to analyze specimens from 20 Finnish nephropathia epidemica (NE) patients hospitalized during the period from October 1994 to January 1995. Blood and/or urine sediment specimens from seven patients were found to be positive for the genome sequences of Puumala hantavirus (PUU). PCR positivity of the specimens from the patients correlated well with the HLA-DRB1*0301 and HLA B8 alleles, which previously were shown to associate with severe courses of NE. Genetic analysis of the partial M-and/or S-segment sequences obtained from three severely ill NE patients revealed three PUU strains related to but distinct from previously reported strains from Finland. The M-segment sequence of PUU from bank voles trapped near the probable site of infection for one of the patients showed 98.2% identity to that of the PUU strain obtained from the patient, suggesting a link between wild-type PUU from the natural focus and the NE case. The S-segment sequences from the patient and the bank voles, however, showed substantially lower identity (95.8%). As this difference in diversity for M and S genes (1.8 and 4.2%) is atypical for PUU genetic drift, one possibility is that the strain acquired at the putative place of infection is a reassortant one.

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Section: Discussionsupporting

confidence: 66%

Puumala hantavirus genome in patients with nephropathia epidemica: correlation of PCR positivity with HLA haplotype and link to viral sequences in local rodents

et al. 1997

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“…[2][3][4][5][6][7][8] Seven members of the virus family Bunyaviridae, genus Hantavirus are known to cause HPS: Andes virus (ANDV), Bayou virus (BAYV), Black Creek Canal virus (BCCV), Choclo virus (CHOV), Laguna Negra virus (LANV), New York virus (NYV), and Sin Nombre virus (SNV). 3,5,6,[9][10][11][12] None of the 9 other hantaviruses native to the Americas, including Maporal virus (MAPV), has been associated with HPS or any other human disease. [13][14][15] Specific members of the rodent family Cricetidae are the principal hosts of the hantaviruses known to cause HPS.…”

Section: Introductionmentioning

confidence: 99%

Choclo Virus Infection in the Syrian Golden Hamster

Eyzaguirre

Milazzo

Koster

et al. 2008

The American Journal of Tropical Medicine and Hygiene

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Andes virus and Choclo virus are agents of hantavirus pulmonary syndrome. Andes virus in hamsters almost always causes a disease that is pathologically indistinguishable from fatal hantavirus pulmonary syndrome. The purpose of this study was to assess the pathogenicity of Choclo virus in hamsters. None of 18 hamsters infected with Choclo virus exhibited any symptom of disease. No evidence of inflammation or edema was found in the lungs of the 10 animals killed on days 7, 9, 11, 13, and 16 post-inoculation or in the lungs of the 8 animals killed on day 28 post-inoculation; however, hantavirus antigen was present in large numbers of endothelial cells in the microvasculature of the lungs of the animals killed on days 7, 9, 11, and 13 post-inoculation. These results suggest that infection in the microvasculature of lung tissue alone does not result in the life-threatening pulmonary edema in hamsters infected with Andes virus.

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“…P. leucopus have been used for studies of social interactions and stress physiology (Southwick 1964), as well as for the investigation of photoperiodism and the action of melatonin on the regulation of hormone secretion and reproductive physiology (Glass & Lynch 1982;Glass & Knotts 1987;Glass & Dolan 1988;Weaver et al 1990). These animals came to public attention as the primary reservoir host for Borrelia burgdorferi sensu stricto, the aetiological agent of lyme disease (Magnarelli et al 1988(Magnarelli et al , 1994Hofmeister & Childs 1995;Hofmeister et al 1999), and they may also be hosts for species of hantavirus (Hjelle et al 1995;Lyubsky et al 1996;Morzunov et al 1998). More recent studies have focused on behavioural and reproductive physiology of P. leucopus mice using different breeding practices under long-term captivity, with data showing that adaptation can be rapid, affecting reproductive patterns and behaviour, even under breeding protocols designed to minimize the rate of genetic change due to random drift and inadvertent selection (Malo et al 2010;Lacy et al 2013).…”

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confidence: 99%

Peromyscus leucopus mice: a potential animal model for haematological studies

Sun

Desierto

Ueda

et al. 2014

Int J Experimental Path

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Peromyscus leucopus mice share physical similarities with laboratory mice Mus musculus (MM) but have higher agility and longer lifespan. We compared domesticated P. leucopus linville (PLL) and M. musculus C57BL/6 (MMB6) mice for cellular composition of peripheral blood (PB), bone marrow (BM) and spleen. PLL mice had significantly fewer platelets and significantly more monocytes in the blood, and notably fewer megakaryocytes in the BM. Spleens of PLL mice were significantly smaller, with 50% fewer cells and reduced 'red pulp'. There was no obvious haematological change in PLL mice between 2-8 and 16-26 months of age, except for a significant increase in blood monocytes. Cellular reactive oxygen species (ROS) content showed no change with age but differed significantly between different cell types. Treating two to eight month-old PLL mice with antioxidant N-acetylcysteine in drinking water for three months did not affect cellular ROS content, but increased blood leucocytes especially the concentration of monocytes. The low platelets, low megakaryocytes, high monocytes and low splenic erythropoiesis in PLL mice resemble human measurements better than the values seen in MMB6.

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Molecular linkage of hantavirus pulmonary syndrome to the white-footed mouse, Peromyscus leucopus: genetic characterization of the M genome of New York virus

Cited by 98 publications

References 37 publications

Puumala hantavirus genome in patients with nephropathia epidemica: correlation of PCR positivity with HLA haplotype and link to viral sequences in local rodents

Puumala hantavirus genome in patients with nephropathia epidemica: correlation of PCR positivity with HLA haplotype and link to viral sequences in local rodents

Choclo Virus Infection in the Syrian Golden Hamster

Peromyscus leucopus mice: a potential animal model for haematological studies

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