Molecular iodine-catalyzed multicomponent reactions: an efficient catalyst for organic synthesis

Abstract

The multicomponent reactions (MCRs) consist of two or more synthetic steps which are carried out without isolation of any intermediate thus reducing time, saving money, energy and raw materials. The development of MCRs in the presence of molecular iodine is an efficient approach that meets with the requirements of sustainable chemistry. The aim of this review is to highlight the synergistic effect of the combined use of MCRs and molecular iodine for the development of new eco-compatible methodologies for organic chemistry.

Recent Advances in Iodine-Mediated Organic Reactions

“…单质碘作为有机化学领域结构简单, 性质稳定的试 剂之一, 由于其廉价易得(67.00 $/kg), 操作简便, 反应 丰富等性质在有机合成中有着广泛的应用, 除了最常见 的碘化反应(芳环上的取代反应、酮 α 位的取代反应、 碘仿反应以及与不饱和键的加成反应等), 单质碘还有 着其他多种多样的反应性. 尽管已有许多综述对其反应 性作了一定的概括和总结, 然而这些综述性文章大多集 中于单一反应性的概括(如亲电碘环化反应 [6] 、Lewis 酸 性 [7] 、 含氧官能团转化 [8] 、 脱保护反应 [9] 、 多组分反应 [10] 、 氧化芳香化反应 [11] . 在有机合成中, 人们也经常利用单质碘的这 个特性将硫醇或者硫酚转化成二硫化合物 [15] .…”

Design and characterization of nano-silica-bonded 3-n-propyl-1-sulfonic acid imidazolium chloride {nano-SB-[PSIM]Cl} as a novel, heterogeneous and reusable catalyst for the condensation of arylaldehydes with β-naphthol and alkyl carbamates

“…Furthermore, they decrease energy consuming steps such as separation and purification of intermediates, and improve raw materials consumption. MCRs also present the advantage of synthetic efficiency and simplicity compared with conventional chemical reactions [28][29][30][31].…”

PEG1000-Based Dicationic Acidic Ionic Liquid Catalyzed One-Pot Synthesis of 4-Aryl-3-Methyl-1-Phenyl-1H-Benzo[h]pyrazolo [3,4-b]quinoline-5,10-Diones via Multicomponent Reactions

“…To the best of our knowledge, there is no report on the application of PEG1000-DAIL as acid catalysts for the preparation of 4-aryl-3-methyl-1-phenyl-1H-benzo[h]pyrazolo [3,4-b]quinoline-5,10-diones. This paper forms part of our ongoing interest in ILs [18][19][20][21][22] and MCRs [1,[28][29][30][31]. We report herein a simple and efficient procedure for the preparation of 4-aryl-3-methyl-1-phenyl-1H-benzo [h]pyrazolo [3,4-b]quinoline-5,10-diones using PEG1000-DAIL as an effective and reusable catalyst (Scheme 1).…”

“…From this viewpoint, it is desirable to achieve multi-bond formation in one operation. Multicomponent reactions (MCRs) allow the creation of several bonds in a single operation and are attracting increasing attention as one of the most powerful emerging synthetic tools for the creation of molecular diversity and complexity [1].…”