Molecular Iodine Catalyzed Highly Rapid Synthesis of 1,5‐Benzodiazepine Derivatives Under Mild Conditions

Hydrated ferric perchlorate, Fe(ClO4)3.XH2O in organic synthesis. A short review

“…A variety of catalysts such as BF 3 .OEt 2 [101], NaBH 4 [102], PPA-SiO 2 [103], MgO-POCl 3 [104], Yb(OTf) 3 [105], Al 2 O 3 -P 2 O 5 [106], HOAc-microwave [101][102][103][104][105][106][107], SO 4 2--ZrO 2 [108], I 2 [109], InBr 3 [110], Ag 3 PW 12 O 40 [111], [L-proline] 2 Zn [112], Solid acid [113] and ionic liquids [114,115] have been employed to affect this transformation. Due to interesting application of 1,5-benzodiazepines, we have recently reported a novel and efficient solvent-free process demonstrated for the synthesis of 1,5-benzodiazepines using ferric perchlorate as a catalyst (Scheme 17).…”

Synthesis of 1-substituted-4-[4-(1H-indol-3-yl)butyl]piperazines

“…Melting points were determined in open capillaries and are uncorrected. NMR spectra were recorded on Varian Unity Inova (300 MHz for 1 H NMR and 75 MHz for 13 C NMR) using residual solvent peaks as internal standards. The purity of compounds was monitored by TLC using silica gel 60 F254 aluminum plates (Merck).…”

Catalytic synthesis of 2,3-dihydro-1H-1,5-benzodiazepines by ferric perchlorate

“…Due to their wide range of pharmacological activity, synthetic and industrial applications, the synthesis of these compounds has recently received a great deal of attention for the discovery of improved protocols towards milder and high yielding approaches. A variety of catalysts such as BF 3 ·OEt 2 [6], NaBH 4 [7], PPA-SiO 2 [8], MgO-POCl 3 [9], Yb(OTf) 3 [10], Al 2 O 3 -P 2 O 5 [11], HOAc-microwave [12], SO 4 −2 -ZrO 2 [13], I 2 [14], InBr 3 [15], Ag 3 PW 12 O 40 [16], [l-proline] 2 Zn [17], solid acid [18] and ionic liquids [19,20] have been employed to affect this transformation.…”