Molecular interactions in ethyl acetate-chlorobenzene binary solution: Dielectric, spectroscopic studies and quantum chemical calculations

Karthick, N.; Kumbharkhane, A.C.; Joshi, Y.S.; Mahendraprabu, A.; Shanmugam, Ramasamy; Elangovan, A.; Arivazhagan, G.

doi:10.1016/j.saa.2017.01.068

Cited by 7 publications

(2 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…38 Additionally, it is also capable of forming C−H•••π interactions with the benzoyl chloride π system through the ethyl group of the ester. 40 These ethyl acetate−IMC interactions might hinder the assembly of IMC molecules to form preassemblies leading to the formation of crystal nuclei. Hydrogen bonding of the acetone molecule with the carboxyl group of the IMC molecule is also shown in Figure 8.…”

Section: Induction Time Of Indomethacin Exemplary Results From Induct...mentioning

confidence: 99%

“…Ethyl acetate, with two hydrogen-bond acceptors, is capable of forming a hydrogen bond only with the carboxylic group of IMC, as shown in Figure ; however, it has been reported to interact with the π system of the indole ring . Additionally, it is also capable of forming C–H···π interactions with the benzoyl chloride π system through the ethyl group of the ester . These ethyl acetate–IMC interactions might hinder the assembly of IMC molecules to form preassemblies leading to the formation of crystal nuclei.…”

Section: Results and Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Cooling Crystallization of Indomethacin: Effect of Supersaturation, Temperature, and Seeding on Polymorphism and Crystal Size Distribution

Malwade

2018

Org. Process Res. Dev.

View full text Add to dashboard Cite

In this work, the effect of crystallization parameters, i.e., supersaturation, seeding, and temperature, on the polymorphism and crystal size of a nonsteroidal anti-inflammatory drug, indomethacin (IMC), was investigated. First, several crystallization solvents (ethanol, methanol, ethyl acetate, acetone, acetonitrile, and dichloromethane) were screened through the measurement of IMC solubility at different temperatures. This was followed by the investigation of IMC nucleation through measurement of induction times in selected solvents at two supersaturations. Finally, seeded cooling crystallization of IMC in ethanol was performed with different process parameters to investigate the influence on the polymorphism and crystal size distribution. Remarkably long induction times were observed for IMC in ethanol and ethyl acetate solutions, while a shorter induction time was observed in acetone. Cooling crystallization of IMC from ethanol confirmed that supersaturation, operating temperature, and seeding do affect the polymorphism as well as crystal size distribution of IMC. Fine needle-shaped crystals of metastable α-IMC were obtained at 5 °C with high supersaturation even in the presence of γ-IMC seeds, while rhombic platelike crystals of thermodynamically stable γ-IMC were obtained in the remaining experiments. The seed loading only marginally influenced the crystal growth rate and median particle diameter. Particle size analysis of the crystals obtained showed a bimodal distribution in all experiments, and a larger median particle diameter was observed at 15 °C with high supersaturation.

show abstract

Section: Induction Time Of Indomethacin Exemplary Results From Induct...mentioning

confidence: 99%

Section: Results and Discussionmentioning

confidence: 99%

Cooling Crystallization of Indomethacin: Effect of Supersaturation, Temperature, and Seeding on Polymorphism and Crystal Size Distribution

Malwade

2018

Org. Process Res. Dev.

View full text Add to dashboard Cite

show abstract

Hydrogen bond interactions in the binary solutions of ethyl acetate with nitrobenzene: Spectroscopic, theoretical and dielectric studies

Karthick¹,

Arivazhagan²,

Kannan³

et al. 2018

Journal of Molecular Liquids

View full text Add to dashboard Cite

Hydrogen bond interactions of ethyl acetate with methyl Cellosolve: FTIR spectroscopic and dielectric relaxation studies

Mahendraprabu¹,

Sangeetha²,

Kannan³

et al. 2020

Journal of Molecular Liquids

View full text Add to dashboard Cite

Molecular interactions in ethyl acetate-chlorobenzene binary solution: Dielectric, spectroscopic studies and quantum chemical calculations

Cited by 7 publications

References 31 publications

Cooling Crystallization of Indomethacin: Effect of Supersaturation, Temperature, and Seeding on Polymorphism and Crystal Size Distribution

Cooling Crystallization of Indomethacin: Effect of Supersaturation, Temperature, and Seeding on Polymorphism and Crystal Size Distribution

Hydrogen bond interactions in the binary solutions of ethyl acetate with nitrobenzene: Spectroscopic, theoretical and dielectric studies

Hydrogen bond interactions of ethyl acetate with methyl Cellosolve: FTIR spectroscopic and dielectric relaxation studies

Contact Info

Product

Resources

About