Molecular interactions in diffusion-controlled aldol condensation with mesoporous silica nanoparticles

Abstract

The aldol reaction of p-nitrobenzaldehyde in amino-catalyzed mesoporous silica nanoparticles (MSN) has revealed varying catalytic activity with the size of the pores of MSN. Detailed molecular-level analysis requires assessment of...

Tissue distribution, placental transfer and excretion of silver nanoparticles in pregnant rats after a single oral dose

“…On these bases, the placental transfer would occur essentially through its semi-permeable membrane determined by physical characteristics such as the thickness of the membrane, pore size, molecular weight of a substance on another side of the membrane, perfusion pressure (maternal blood pressure), and placental flow [ 17 ]. The diffusion process depends also on molecular size and spatial configuration, ionic dissociation, and liquid solubility substance [ 18 ]. In the present study, the AgNPs accumulated in the whole body of fetuses were higher than the remaining NPs in placental sections at different time points indicating a transfer of NPs to the fetus and amniotic fluid.…”

“…Additionally, their ability to form ROS is considered the main pathway for NPs genotoxic effects and other risks. Increased Reactive Oxygen Species (ROS) level is related to a series of events leading to membrane damage, DNA and protein damage, and apoptosis or necrosis [ 18 ].…”