Molecular interaction between methicillin-resistant Staphylococcus aureus (MRSA) and chicken breast reveals enhancement of pathogenesis and toxicity for food-borne outbreak

Chung, Han Young; Kim, You‐Tae; Kwon, Joon-Gi; Im, Han Hyeok; Ko, Dae-Hyun; Lee, Ju-Hoon; Choi, Sang Ho

doi:10.1016/j.fm.2020.103602

Cited by 18 publications

(6 citation statements)

References 82 publications

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“…MRSA is a type of highly resistant zoonotic microorganism considered as the third most significant factor of disease worldwide among reported food-borne illnesses . Many countries have reported outbreaks of livestock-associated MRSA, including Korea, , Denmark, China, Italy, and India . These pathogens are derived from many sources, including pigs, pig farmers, slaughterhouse environment, open markets, food products, nursing homes, and pork, , which increases the risk of human exposure to MRSA with toxic infections.…”

Section: Resultsmentioning

confidence: 99%

ZnO@Polyvinyl Alcohol/Poly(lactic acid) Nanocomposite Films for the Extended Shelf Life of Pork by Efficient Antibacterial Adhesion

et al. 2022

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The proliferation of microorganisms is an important reason for meat spoilage and deterioration. Freezing and packaging by polymer films and preservatives are commonly used to preserve meat. While the energy consumption of freezing is very big, the polymer films made by petroleum bring up heavy environmental pressure. In the present study, biodegradable antibacterial ZnO@PLA (ZP) and ZnO@PVA/PLA (ZPP) nanocomposite films used as food packaging have been synthesized by the solvent evaporation method and coating method, respectively. Compared with films without ZnO NPs, ZP and ZPP both had long-term bacteriostasis for 24 and 120 h at temperatures of 25 and 4 °C, respectively. Moreover, the antibacterial effect showed positive relevance with the increase of the ZnO NP concentration. In addition, the antibacterial effect of ZPP was better than that of ZP in the same condition. Scanning electron microscopy showed that the numbers of methicillin-resistant staphylococcus aureus (MRSA) on ZP and ZPP were significantly reduced compared to that in the blank film, and ZPP caused the morphology of MRSA to change, which means that the antibacterial mechanism of ZP and ZPP composite films might be related to antibacterial adhesion. In conclusion, ZPP films have great potential to be regarded as the candidate of food packing to extend the shelf life of pork.

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Section: Resultsmentioning

confidence: 99%

ZnO@Polyvinyl Alcohol/Poly(lactic acid) Nanocomposite Films for the Extended Shelf Life of Pork by Efficient Antibacterial Adhesion

et al. 2022

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“…Coagulase-positive staphylococci (CoPS), such as Staphylococcus aureus and Staphylococcus pseudintermedius, have been linked to both human and animal health [4][5][6]. Staphylococcal infections have been frequently observed in humans, dogs, cats, horses, sheep, pigs, cattle, and chickens [7][8][9][10][11][12]. Methicillin-resistant CoPS (MRCoPS) are opportunistic pathogens that have at least one drug resistance gene on their chromosome, such as mecA or mecC, which compromises or abolishes the efficacy of beta-lactam agents in antimicrobial therapy [4,[13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Methicillin-resistant coagulase-positive staphylococci in new, middle-aged, and old veterinary hospitals in southern Thailand: A preliminary study

Soimala,

Wasiksiri,

Boonchuay

et al. 2024

Vet World

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Background and Aim: Methicillin-resistant coagulase-positive staphylococci (MRCoPS) cause pyoderma, dermatitis, and nosocomial infection. Numerous factors, including indiscriminate antimicrobial use (AMU) in veterinary medicine, cleaning practices, and AMU in hospitals, contribute to MRCoPS. However, the relationship between hospital age and MRCoPS has not yet been investigated. This study aimed to estimate the prevalence of MRCoPS in the treatment and operation rooms of new, middle-aged, and old veterinary hospitals. Materials and Methods: Samples were collected from small animal hospitals in Surat Thani, Nakhon Si Thammarat, and Songkhla in Thailand. Hospitals were defined as those that had been in operation for 5 years (new, n = 5), 5–15 years (middle-aged, n = 6), or >15 years (old, n = 3). Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry was used to identify 280 samples, and duplex polymerase chain reaction was used to identify resistance genes (mecA and blaZ). The VITEK2® automated system was then used to determine the minimum inhibitory concentration. Results: A total of 57 Staphylococcus species were identified and classified as coagulase-positive staphylococci (CoPS) (22/57, 38.60%) or coagulase-negative staphylococci (35/57, 61.40%), respectively. Nine of the 22 CoPS (40.90%) harbored the mecA gene, and 21 isolates (95.45%) harbored the blaZ gene. Interestingly, more MRCoPS was found in new hospitals (six isolates) than in middle-aged (one isolate) and old hospitals (two isolates), although there was no statistically significant difference in the presence of MRCoPS across new, middle-aged, and old veterinary hospitals (p = 0.095), Kruskal–Wallis test. There is a need for further detailed studies, including an increase in the number of hospitals in various locations. Conclusion: MRCoPS is a nosocomial pathogen that causes zoonotic and recurrent infections in veterinary hospitals. The prevalence of MRCoPS tended to be higher in new hospitals. Areas with heavy animal contact, such as hospital floors, are areas of particular concern, and cleaning/disinfection of these areas must be highlighted in hygiene regimens. Keywords: antimicrobial susceptibility, methicillin resistance, Staphylococcus spp.

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“…4 Numerical data analyses related to methicillin-resistant Staphylococcus aureus (MRSA), the most commonly identified antibiotic-resistant pathogen known worldwide, 5 showed that infections caused by eating food contaminated with S. aureus might be more lethal due to the increased virulence factors and antibiotic-resistance activities in clinical MRSA. 6 The profile of AMR showed that S. aureus from food were more resistant than those from human. 7 To solve the AMR problem, the treatment strategy of S. aureus infection has been transferred to anti-virulence agents targeting virulence-related path-ways and proteins, 8 which have been developed by using multiple strategies, including the regulation of virulence expression, inhibition of toxin function, and interference with the adhesion of the pathogen.…”

Section: Introductionmentioning

confidence: 99%

Molecular mechanism of green tea polyphenol epicatechin gallate attenuating Staphylococcus aureus pathogenicity by targeting Ser/Thr phosphatase Stp1

Gao

Wang

et al. 2023

Food Funct.

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Molecular interaction between methicillin-resistant Staphylococcus aureus (MRSA) and chicken breast reveals enhancement of pathogenesis and toxicity for food-borne outbreak

Cited by 18 publications

References 82 publications

ZnO@Polyvinyl Alcohol/Poly(lactic acid) Nanocomposite Films for the Extended Shelf Life of Pork by Efficient Antibacterial Adhesion

ZnO@Polyvinyl Alcohol/Poly(lactic acid) Nanocomposite Films for the Extended Shelf Life of Pork by Efficient Antibacterial Adhesion

Methicillin-resistant coagulase-positive staphylococci in new, middle-aged, and old veterinary hospitals in southern Thailand: A preliminary study

Molecular mechanism of green tea polyphenol epicatechin gallate attenuating Staphylococcus aureus pathogenicity by targeting Ser/Thr phosphatase Stp1

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