Molecular interaction between mercury and selenium in neurotoxicity

Bjørklund, Geir; Aaseth, Jan; Ajsuvakova, Olga P.; Nikonorov, Alexandr А.; Skalny, Anatoly V.; Skalnaya, Margarita G.; Tinkov, Alexey A.

doi:10.1016/j.ccr.2016.10.009

Cited by 117 publications

(55 citation statements)

References 105 publications

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“…It has numerous important biological functions, serving as the active center of selenoenzymes and selenoproteins, playing an integral role in energy metabolism and gene expression, and functioning in multiple antioxidant, immunoregulatory, and antagonistic roles (Izquierdo et al 2010;Roman et al 2014). Selenium has long been recognized for its potential in reducing the toxicity of Hg compounds and has been postulated as a core element in the in vivo demethylation pathway of methylmercury (Bjørklund et al 2017;Khan and Wang 2010). In animals, interactions between Hg and Se depend mainly on the chemical form and concentration of both elements in the environment duration of exposure, and the species in question (Bjerregaard et al 2011;Cuvin-Aralar and Furness 1991).…”

Section: Introductionmentioning

confidence: 99%

Selenium and mercury in the hair of raccoons (Procyon lotor) and European wildcats (Felis s. silvestris) from Germany and Luxembourg

et al. 2019

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This study examined the concentration of total mercury (THg) and selenium (Se), as well as the molar ratio of Se:THg in hair samples of terrestrial animals. THg and Se concentrations were measured from the hair of raccoons (Procyon lotor) and European wildcats (Felis s. silvestris) from Germany and Luxembourg. Median THg concentrations in hair from raccoons and wildcats were 0.369 and 0.273 mg kg −1 dry weight (dw), respectively. Se concentrations were higher in the hair of raccoons than of wildcats (0.851 and 0.641 mg kg −1 dw, respectively). Total mercury concentration in hair of raccoons from Luxembourg was almost 5× higher that found in hair of raccoons from Germany; however, Se concentration was similar. Thus, molar ratio of Se:THg was~4× higher in the hair of raccoons from Germany than those from Luxembourg. Significant negative correlation was found between THg concentration and Se:THg molar ratio in both wildcats and raccoons.

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Section: Introductionmentioning

confidence: 99%

Selenium and mercury in the hair of raccoons (Procyon lotor) and European wildcats (Felis s. silvestris) from Germany and Luxembourg

et al. 2019

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“…A study, has shown a significant negative exponential relationship between Se and Hg in blood samples of persons living in a mining area in China[21]. Due to the biological interactions between Se and Hg, which indicate that Hg binds to biomolecules/proteins bond to Se (Selenoproteins) to form a coordinated complexes[21] [22], and that Hg sequesters Se[23], it is understandable that co-presence of Se and Hg in breast milk will have a reducing effect on the amount of Se and also its availability to infants who ingest such breast milk. Additionally, since the amount of Se is not biologically regulated, and the influence of the presence of a toxic element is by competitive binding, the extent of the influence will depend on the relative amounts of Se and the toxic metal[23].…”

mentioning

confidence: 99%

“…Additionally, since the amount of Se is not biologically regulated, and the influence of the presence of a toxic element is by competitive binding, the extent of the influence will depend on the relative amounts of Se and the toxic metal[23]. Therefore, the influence, even if it is possible, may not be evident once Se is present in relatively higher amounts[15] [22]. Based on the understanding of the biological interactions between Se and Hg, Se has been used in the reduction of the amount and toxicity of Hg by giving Se supplementation to Hg exposed persons/organisms[21] [22] [24] [25] [26].…”

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confidence: 99%

Double Burden of Malnutrition: Toxic Metals in Breast Milk May Limit the Amounts of Micronutrients Available to Infants through Breast Milk

Awua¹,

Boatin²,

Adom³

et al. 2019

FNS

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Background: The amounts of micronutrients in the diets of infants, and the factors that influence them needs to be monitored at the population level in order to avert detrimental developmental defects that impose lifetime-limitations on an infant's regulatory and defense systems. This study therefore, sought to evaluate if increasing levels of the toxic metals, Hg, Pb and Cd in breast milk will result in reducing amounts of the micronutrients Zn, Se and Cu in breast milk. Methods: Breast milk samples of 114 women living in two mining areas (57 women each) in Ghana, whose babies' amounts of breast milk intake at three months postpartum, and amounts of toxic metals had previously been determined in a prospective study, were analyzed for micronutrients by a combination of acid and microwave digestion, and quantifications were by two different modes (hydrogen and helium) of Octapole Reaction System Inductively Coupled Plasma Mass Spectrometer (7500 ce. Agilent), equipped with an ASX-510 Auto-sampler (Cetac). Results: All the breast milk specimen collected contained detectable amounts of Cu, Zn, both at levels less than have been previously reported, and Se. For specimen that did not contain Pb the amount of Se ranged from about 110 to 245 ng/g of milk, however, as the amount of Pb increased, the corresponding highest detected amount of Se reduced steeply, resulting in a right-angle triangle-shaped scatter plot. Similar relationships were observed between other toxic metals and micronutrients studied. A curve fitting regression analysis showed significant qua

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“…In brain cells, the Hg 2+ ‐ions exert toxic effects by their affinity and binding to essential thiol groups on enzymes and structural components, that is on microtubules in the neuronal cytoskeleton, which may lead to deteriorations with dysfunctional neurotransmitter release . Furthermore, dysfunctional cerebral transmitter function might also be precipitated by interactions of the electrophilic Hg compounds with biological selenol groups . Elevations of cerebral amyloid protein expression might also be induced by Hg …”

Section: Metabolism Of Mercurymentioning

confidence: 99%

Neurotoxic effects of mercury exposure in dental personnel

Bjørklund

Hilt

Dadar

et al. 2019

Basic Clin Pharma Tox

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Numerous studies have reported neurobehavioural effects in dental personnel occupationally exposed to chronic low levels of mercury (Hg). Hg exposure from dental work may also induce various chronic conditions such as elevation of amyloid protein expression, deterioration of microtubules and increase or inhibition of transmitter release at motor nerve terminal endings. Therefore, clinical studies of Hg toxicity in dentistry may provide new knowledge about disturbed metal homeostasis in neurodegenerative diseases such as Alzheimer's disease, multiple sclerosis and mood disorders. The purpose of this MiniReview is to evaluate the evidence of possible relevance between Hg exposure in dentistry and idiopathic disturbances in motor functions, cognitive skills and affective reactions, as well as dose-response relationships. K E Y W O R D Scognitive functions, dental personnel, mercury, mood and symptoms, motor functions 42

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Molecular interaction between mercury and selenium in neurotoxicity

Cited by 117 publications

References 105 publications

Selenium and mercury in the hair of raccoons (Procyon lotor) and European wildcats (Felis s. silvestris) from Germany and Luxembourg

Selenium and mercury in the hair of raccoons (Procyon lotor) and European wildcats (Felis s. silvestris) from Germany and Luxembourg

Double Burden of Malnutrition: Toxic Metals in Breast Milk May Limit the Amounts of Micronutrients Available to Infants through Breast Milk

Neurotoxic effects of mercury exposure in dental personnel

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