Molecular Insights Provide the Critical Path to Disease Mitigation

Abstract

The revolution in scientific innovation, driven by the engines of enabling technologies, is increasingly capable of deconstructing complex disease processes for the express purpose of reconstructing patient-specific solutions. These revelations in biological mechanisms provide the pressure points of opportunity for radical discovery and development to advance modern health care. Principles of mechanism-based discovery and their translation into therapeutic algorithms will, however, be challenged in the near term by emerging global public health crises that currently have no immediate solutions: chronic diseases, obesity, antibiotic-resistant infections, dementia, depression. The threat of these pandemics (multiplied in an increasingly aging population), the global burden of disease they represent, and their worldwide assault on human capital underscore the importance of continued and accelerated investments in science-propelled practice advancement, converting new knowledge into delivery of tangible health solutions. In that context, this annual issue of CPT on therapeutics innovations highlights remarkable recent successes in the discovery-development paradigm translating molecular innovations into diagnostic and therapeutic realities that transform the management of disease, impacting global health.

Capital humano e innovación en el sector salud. Una revisión sistemática de literatura y análisis cienciométrico

“…Kato et al (2014), Japón Experiencia, especialización y educación del recurso humano. Waldman et al (2014), Estados Unidos Desarrollo e investigación, procesos innovadores, tecnologías de la información y comunicación, inversiones en la ciencia, conversión de nuevos conocimientos en entrega de activos materiales. Karami et al (2015), global Conocimiento, habilidades, educación, experiencia, innovación, creatividad, resolución de problemas, lealtad, flexibilidad, experiencia, competencia, motivación, compromiso, actitud, agilidad, gestión de recursos, inteligencia organizacional en la especialización, en los datos del negocio, en las tecnologías y en las relaciones del ambiente y los agentes externos.…”

Affairs of the Heart: Innovation in Cardiovascular Research and Development

“…Clinical trial experience suggests an early hemodynamic benefit, and possible impact on the myocardial substrate for heart failure progression. Scientific innovation, driven by enabling technologies, aims at deconstructing intricate disease processes for the express purpose of reconstructing patient‐specific solutions …”

Big Data Transforms Discovery–Utilization Therapeutics Continuum

“…The emergence of enabling medical technologies has revolutionized our ability to precisely define the detailed characteristics of individuals in sickness and health. Omic technologies offer a view of organization and function at the level of integrated molecular systems, while next‐generation imaging imparts structure to those systems at the cell, tissue, organ, and organismal levels . Beyond these biological determinants, environmental elements that provide the context for molecular structure and function and, ultimately, shape pathobiology are memorialized in the longitudinal electronic health record (EHR) .…”