Molecular insights into diabetic cardiomyopathy

Barman, Chayanika; Pandey, Rajesh; Singh, Jasbir; Sodhi, Kirandeep

doi:10.18203/2320-6012.ijrms20150230

Cited by 4 publications

(3 citation statements)

References 9 publications

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“…Hyperglycemia-induced excessive production of ROS is the main underlying mechanism of diabetes-induced cardiomyocyte damage [ 126 ]. Prolonged hyperglycemia can induce metabolic and molecular changes leading to myocardial injury [ 127 ]. Redox imbalance in the diabetic heart leads to oxidative DNA damage and accelerated myocardial apoptosis [ 128 ].…”

Section: Therapeutic Potential Of Citrus Flavonoids In Diabetes Anmentioning

confidence: 99%

Beneficial Effects of Citrus Flavonoids on Cardiovascular and Metabolic Health

Mahmoud

Hernández-Bautista

Sandhu

et al. 2019

Oxidative Medicine and Cellular Longevity

211

129

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The prevalence of cardiovascular disease (CVD) is increasing over time. CVD is a comorbidity in diabetes and contributes to premature death. Citrus flavonoids possess several biological activities and have emerged as efficient therapeutics for the treatment of CVD. Citrus flavonoids scavenge free radicals, improve glucose tolerance and insulin sensitivity, modulate lipid metabolism and adipocyte differentiation, suppress inflammation and apoptosis, and improve endothelial dysfunction. The intake of citrus flavonoids has been associated with improved cardiovascular outcomes. Although citrus flavonoids exerted multiple beneficial effects, their mechanisms of action are not completely established. In this review, we summarized recent findings and advances in understanding the mechanisms underlying the protective effects of citrus flavonoids against oxidative stress, inflammation, diabetes, dyslipidemia, endothelial dysfunction, and atherosclerosis. Further studies and clinical trials to assess the efficacy and to explore the underlying mechanism(s) of action of citrus flavonoids are recommended.

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Section: Therapeutic Potential Of Citrus Flavonoids In Diabetes Anmentioning

confidence: 99%

Beneficial Effects of Citrus Flavonoids on Cardiovascular and Metabolic Health

Mahmoud

Hernández-Bautista

Sandhu

et al. 2019

Oxidative Medicine and Cellular Longevity

211

129

View full text Add to dashboard Cite

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“…Myocardial cell apoptosis is an important pathophysiological mechanism in DCM. Apoptosis, also known as programmed cell death, plays an important role in maintaining the normal morphology and function of tissues and organs; DCM researcher has focused on the protein expression of apoptosis-related genes in cardiomyocytes [19–21]. The Bcl-2 family of proteins plays an important role in the process of apoptosis.…”

Section: Discussionmentioning

confidence: 99%

The Chinese Herb Yi‐Qi‐Huo‐Xue Protects Cardiomyocyte Function in Diabetic Cardiomyopathy

Wang

Huang

Wang

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Aims. To study the effect of the Chinese herb Yi-qi-huo-xue on cardiomyopathy in diabetic rats. Methods. Rats were fed a high fat and high glucose diet and injected with 50 ml/kg streptozotocin (STZ) to induce diabetic cardiomyopathy (DCM), followed by treatment with Yi-qi-huo-xue for 4 weeks. We measured the rats' heart weight index, observed the myocardial morphology using hematoxylin eosin (HE) staining, and determined the content of collagen types I and III in the myocardium using enzyme-linked immunosorbent assay (ELISA). We determined Bcl-2, Bax, and P53 protein expression by Western blot analysis and the cardiomyocyte apoptosis rate via a flow cytometry assay. Results. Compared with the rats in the control group, the diabetic rats gained weight and had increased blood sugar levels, an enhanced heart weight index, and increased myocardial pathophysiological damage. There was a decrease in their Bcl-2 expression, and their Bax and P53 expression increased. The Bcl-2/Bax ratio was enhanced, and there was an increase in the content of collagen types I and III in the myocardium. After treatment with Yi-qi-huo-xue, all levels listed above returned to normal. Conclusion. The Chinese herb Yi-qi-huo-xue degraded the myocardial interstitial collagen types I and III to protect the myocardium of the diabetic rats, thus delaying the role of myocardial fibrosis. Yi-qi-huo-xue could play an important role in protecting the myocardium of DCM rats by enhancing the expression of the Bcl-2 protein, inhibiting the expression of the Bax and P53 proteins, increasing the ratio of Bcl-2/Bax, and inhibiting the apoptosis of cardiomyocytes.

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“…Accumulating evidence indicates that hyperglycemia is one of the main pathological mechanisms in DCM [ 81 , 82 , 83 ]. However, the long-standing hyperglyceia induces some metabolic and molecular changes in the myocardial cells [ 84 ]. These metabolic changes result in the generation of reactive oxygen species (ROS) from mitochondria, as well as a reduction in capacity of the key antioxidant enzyme glutathione reductase and formation of advanced-glycation end-products (AGEs) [ 85 ].…”

Section: Attenuation Of Secondary Mitochondrial Diseases By Catechinsmentioning

confidence: 99%

A Comprehensive Review on Beneficial Effects of Catechins on Secondary Mitochondrial Diseases

Chen

Zhang

Lin

et al. 2022

IJMS

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Mitochondria are the main sites for oxidative phosphorylation and synthesis of adenosine triphosphate in cells, and are known as cellular power factories. The phrase “secondary mitochondrial diseases” essentially refers to any abnormal mitochondrial function other than primary mitochondrial diseases, i.e., the process caused by the genes encoding the electron transport chain (ETC) proteins directly or impacting the production of the machinery needed for ETC. Mitochondrial diseases can cause adenosine triphosphate (ATP) synthesis disorder, an increase in oxygen free radicals, and intracellular redox imbalance. It can also induce apoptosis and, eventually, multi-system damage, which leads to neurodegenerative disease. The catechin compounds rich in tea have attracted much attention due to their effective antioxidant activity. Catechins, especially acetylated catechins such as epicatechin gallate (ECG) and epigallocatechin gallate (EGCG), are able to protect mitochondria from reactive oxygen species. This review focuses on the role of catechins in regulating cell homeostasis, in which catechins act as a free radical scavenger and metal ion chelator, their protective mechanism on mitochondria, and the protective effect of catechins on mitochondrial deoxyribonucleic acid (DNA). This review highlights catechins and their effects on mitochondrial functional metabolic networks: regulating mitochondrial function and biogenesis, improving insulin resistance, regulating intracellular calcium homeostasis, and regulating epigenetic processes. Finally, the indirect beneficial effects of catechins on mitochondrial diseases are also illustrated by the warburg and the apoptosis effect. Some possible mechanisms are shown graphically. In addition, the bioavailability of catechins and peracetylated-catechins, free radical scavenging activity, mitochondrial activation ability of the high-molecular-weight polyphenol, and the mitochondrial activation factor were also discussed.

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Molecular insights into diabetic cardiomyopathy

Cited by 4 publications

References 9 publications

Beneficial Effects of Citrus Flavonoids on Cardiovascular and Metabolic Health

Beneficial Effects of Citrus Flavonoids on Cardiovascular and Metabolic Health

The Chinese Herb Yi‐Qi‐Huo‐Xue Protects Cardiomyocyte Function in Diabetic Cardiomyopathy

A Comprehensive Review on Beneficial Effects of Catechins on Secondary Mitochondrial Diseases

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