Molecular Inflammation in the Contralateral Eye After Cataract Surgery in the First Eye

Zhu, Xiangjia; Wolff, Don; Zhang, Ke-Ke; He, Wenwen; Sun, Xinghuai; Lu, Yi; Zhou, Peng

doi:10.1167/iovs.15-16531

Cited by 50 publications

(55 citation statements)

References 48 publications

(49 reference statements)

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“…; Zhu et al. ). A unilateral experimental neurotrophic keratopathy model could cause bilateral nerve alteration (Yamaguchi et al.…”

Section: Discussionmentioning

confidence: 98%

“…Symmetric diurnal fluctuation of intraocular pressure has been reported in normal eyes and eyes with glaucoma (Realini et al 2002;Dinn et al 2007). The aqueous humour protein level was changed in both treated and contralateral eyes in a neurogenic inflammation model or following cataract surgery (Gonzalez et al1993;Zhu et al 2015). A unilateral experimental neurotrophic keratopathy model could cause bilateral nerve alteration (Yamaguchi et al 2013).…”

Section: Discussionmentioning

confidence: 99%

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Bilateral tear film alterations in patients with unilateral quiescent herpes simplex keratitis

2016

Acta Ophthalmologica

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“…; Zhu et al. ). A unilateral experimental neurotrophic keratopathy model could cause bilateral nerve alteration (Yamaguchi et al.…”

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Bilateral tear film alterations in patients with unilateral quiescent herpes simplex keratitis

2016

Acta Ophthalmologica

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“…Another possibility is that the significant inflammatory reaction in eye with stromal ulceration may have caused inflammation in the contralateral eye. In humans, an inflammatory chemokine was significantly increased in the aqueous humor of one eye after cataract surgery was performed in the contralateral eye . The mechanism may be similar to sympathetic ophthalmia …”

Section: Discussionmentioning

confidence: 99%

“…In humans, an inflammatory chemokine was significantly increased in the aqueous humor of one eye after cataract surgery was performed in the contralateral eye. 25 The mechanism may be similar to sympathetic ophthalmia. 26 Diabetes mellitus was the most statistically overrepresented systemic disease to affect dogs diagnosed with LU likely due to development of diabetic cataracts, phacoemulsification, and dyslipidemia.…”

Section: Lipemic Uveitis No Lipemic Uveitis P Valuementioning

confidence: 99%

Lipemic uveitis and its etiologies in dogs: 75 cases

Violette

Ledbetter

2019

Veterinary Ophthalmology

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Objective To describe clinical features of dogs with lipemic uveitis (LU). Animals studied Seventy‐five dogs (114 eyes) with LU. Procedures Medical records of dogs examined by the Cornell University ophthalmology service with a clinical diagnosis of LU between 2008 and 2017 were analyzed. Signalment and clinical case aspects, including concurrent ocular disease, systemic disease, and previous ophthalmic surgery, were recorded. Results Lipemic uveitis was diagnosed in 114 eyes of 75 dogs. The mean (±standard deviation) age of dogs was 9.0 years (±2.7 years). Miniature Schnauzers and Yorkshire Terriers were statistically overrepresented compared to the ophthalmology canine referral population. Lipemic flare varied in severity with loss of menace response due to markedly opaque flare seen in 15/114 eyes (13%). Two dogs developed LU after dietary indiscretion. Forty‐nine eyes (43%) had concurrent ocular disease, most commonly keratoconjunctivitis sicca, ulcerative keratitis, and cataracts. Pseudophakia was present in 75/114 eyes (66%) and LU developed within 30 days of an intraocular surgical procedure in 63/114 eyes (55%). Hypertriglyceridemia was noted in 52 dogs of the 55 dogs tested (95%). Systemic disease affected 54/75 dogs (72%), of which diabetes mellitus, hyperadrenocorticism, and hypothyroidism were overrepresented compared to the referral population. Primary hyperlipidemia was identified in 12 dogs. Lipemic uveitis resolved at first reevaluation in 92/110 eyes (84%) and recurred in 6/114 eyes (5%) after complete resolution. Conclusions Development of lipemic uveitis in dogs appears to require the combination of hyperlipidemia and uveitis. Systemic disease is commonly associated with LU in dogs.

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“…For the remaining 24 animals, 3 of them were euthanized with pentobarbital sodium by intraperitoneal injection at a lethal dose of 100 mg/ kg at each time point; their treated eyes were enucleated and processed for histologic study. Considering the potential effects of surgical stimulation on the contralateral untreated eye, 27 eight animals in the control group were left without surgery. The control group had OCT examination only when they reached the age of 5 months, which was the same age as the surgery group at 3 months postoperatively.…”

Section: Examinationmentioning

confidence: 99%

In Vivo Observation of Lens Regeneration in Rat Using Ultra-Long Scan Depth Optical Coherence Tomography

Zhou

Huang³

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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In vivo observation of lens regeneration in rat using ultralong scan depth optical coherence tomography. Invest Ophthalmol Vis Sci. 2016;57:6615-6623. DOI: 10.1167/iovs.16-19363 PURPOSE. To evaluate morphologic changes of lens regeneration in rats in vivo after extracapsular lens extraction (ECLE) by ultra-long scan depth optical coherence tomography (UL-OCT). METHODS.A total of 42 Sprague-Dawley rats were used in this study. We performed ECLE on the right eyes of animals in the surgery group (n ¼ 34). Biomicroscopy and UL-OCT scans were carried out for the surgery group immediately (within 1 hour postoperatively) and at days 1 and 3, weeks 1 and 2, and months 1, 2, and 3 postoperatively. After in vivo examination, three animals of the surgery group were euthanized at each time point for histology study, while the other 10 animals were examined continuously at those time points. The regenerated lens was evaluated in OCT images at 2 and 3 months postoperatively. The control group consisted of eight untreated rats that had OCT examination at the age of 5 months.RESULTS. Lens regeneration could be observed from 2 weeks postoperatively. Regeneration was mainly at the peripheral capsular bag in the first month and central region thereafter. The average thickness of regenerated lenses was 2222 6 309 and 2324 6 352 lm at 2 and 3 months, respectively. Regeneration was faster in the first 2 months and slowed down thereafter. Although anterior capsule opening and posterior capsule adhesion and wrinkling existed, the regenerated lens still could form a relatively regular shape, however, the size was much smaller than that of the normal lenses from rats with the same age.CONCLUSIONS. Ultra-long OCT provides longitudinal data of the process of lens regeneration on a single individual rat in vivo, which may allow one to follow and compare the lens regenerative process under different interventions or therapy after ECLE in rats.

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Molecular Inflammation in the Contralateral Eye After Cataract Surgery in the First Eye

Cited by 50 publications

References 48 publications

Bilateral tear film alterations in patients with unilateral quiescent herpes simplex keratitis

Bilateral tear film alterations in patients with unilateral quiescent herpes simplex keratitis

Lipemic uveitis and its etiologies in dogs: 75 cases

In Vivo Observation of Lens Regeneration in Rat Using Ultra-Long Scan Depth Optical Coherence Tomography

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