Molecular Impact on High Motility Group Box-1 (HMGB-1) in Pamps and Damp

Idrus, Hasta Handayani; Hatta, Mochammad; Kasim, Vivien novarina a; Febriza, Ami; Arsal, Andi Sitti Fahirah; Hadju, Veni; As’ad, Suryani

doi:10.5958/0976-5506.2019.02045.x

Cited by 7 publications

(4 citation statements)

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“…• Inducing VEFG, MMPs and PDGF [40] • Promoting cell proliferation [41] • Inducing lymphangiogenesis angiogenesis [42] • Inducing secretion of cytokines [43,44] • Regulating autophagy and apoptosis [45,46] • Antibacterial [47] activities, including replication, repair, recombination, transcription, and genomic stability [8]. HMGB-1 is a DNAbinding protein found in most cell types.…”

Section: Hmgb-1's Roles In the Immune Systemmentioning

confidence: 99%

Linking Interaction between Antimicrobial Peptide and High Motility Group Box-1 (HMBG-1) in Bacterial Infection

Febriza,

Idrus

2024

TOBIOCJ

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Antimicrobial peptides (AMPs) are small proteins that protect against bacterial and fungal infections. Various organisms, including plants, animals, and bacteria, produce them. The HMGB-1 (HMGB-1) protein is produced by both immune cells and bacteria, and its main role is to facilitate the recognition of foreign agents, such as bacteria, by the immune system. AMP can protect against infections by interacting with HMGB-1. This enhances their protective capabilities and reduces inflammation associated with bacterial infections.

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Section: Hmgb-1's Roles In the Immune Systemmentioning

confidence: 99%

Linking Interaction between Antimicrobial Peptide and High Motility Group Box-1 (HMBG-1) in Bacterial Infection

Febriza,

Idrus

2024

TOBIOCJ

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“…Tropical infectious disease, namely typhoid fever or better known as typhus disease in Indonesian, is a disease caused by the Salmonella typhi bacteria, the Salmonella typhi bacteria enters through food contaminated by flies' feet, cockroaches' feet, rat's feet where the animal's feet have been infected. Carrying the typhoid fever bacteria and the animal is called an effector or carrier of bacteria the bacteria that were carried earlier and contaminated by food will then be eaten by the patient where some of the bacteria will die in the stomach and some will get to the intestines and in this intestine these bacteria will then multiply and cause intestinal infections [1,2]. After the bacteria have reproduced, it will cause inflammation in the intestines which will lead to the implementation of fever in patients who we know as typhoid fever [3,4].…”

Section: Introductionmentioning

confidence: 99%

The Role of Herbal Medicine in Suppressing the Incidence of Typhoid Fever in Indonesia

Idrus¹,

Sunarno²,

Rinendyaputri³

et al. 2023

Proceedings of the 1st International Conference for Health Research – BRIN (ICHR 2022)

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Typhoid fever is one of the common diseases in developing countries. This is attributable to Salmonella typhi bacteria. The water from the unripe Manila sapodilla was often to be given as a drink on typhoid fever patients. Indonesia is a country that is rich in natural ingredients that can be used as medicine. Currently we are still faced with the problem of typhoid fever that never goes away in Indonesia. Many people in some areas have turned to herbal treatment using available natural ingredients to treat typhoid fever, one of which is to consume sapodilla manila fruit which is strong and effective enough to cure typhoid fever quickly. The method used in this study was to extract the manila sapodilla fruit with the maceration method which was then tested in vitro and in vivo to determine the effectiveness of the manila sapodilla fruit in reducing salmonella typhi colonies that cause typhoid fever. This study was an murine-based in vivo approach where our mice were divided into four groups: two treatment groups, and negative and positive references. Manila sapodilla fruit extract was used to reduce Salmonella typhi colonies that cause typhoid fever. Our results showed that there was a significant decrease in Salmonella typhi bacteria that was treated with Manila sapodilla extract at either dose of 510 mg and 750 mg. This suggested that sapodilla manila extract play a role in weakening Salmonella typhi colonies. Hence, this was deemed as a potential anti typhoid fever as a substitute for the use of antibiotics.

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“…This protein is an intranuclear non-histone protein with a molecular weight of 30-kDa and is a mediator of inflammation and inflammatory responses following tissue damage (injury or infection) hence it is considered an important late inflammatory mediator. Several studies revealed that HMGB1 has molecular impact in Pathogen-Associated Molecular Patterns (PAMPs) in infection and Damage-Associated Molecular Patterns (DAMPs) in injury [ 3 ]. Previous studies showed that HMGB1 has involved in molecular mechanisms of systemic lidocaine treatment for closed fracture musculoskeletal injury in animal model [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory properties of high mobility group box 1 and its potential role in brain injury: Review article

Tommy

Islam

Hatta

et al. 2020

Annals of Medicine and Surgery

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Background Human mobility group box 1 (HMGB1) is a novel biomolecular agent which has a major part in inflammation process. HMGB1 has been known to be a strong pro-inflammatory factor as damage associated molecular pattern (DAMP) which its interaction with its receptor, the receptor of advanced glycation end products (RAGE), will cause positive amplification of inflammation signalling pathway. Brain injury is one of the major contributors for disability and death which neuroinflammation has a major role in its pathogenesis and influencing its outcome. In neuroinflammation, it has been described that HMGB1 may have a pivotal role in the process. Objective The objective of this article is to review the role HMGB1 in brain injury and its immunomodulatory properties. Methods A comprehensive search of literature was conducted in PubMed (NIH), Scopus, EMBASE, and Google Scholar database using keyword combinations of the medical subject headings (MeSH) of “HMGB1” and “Brain Injury” and relevant reference lists were also manually searched. All relevant articles of any study design published from year 1990 till June 2020, were included and narratively discussed in this review. Results Twenty-four articles were shortlisted and reviewed in this article. Through these articles, we synthesis information on the function and metabolism of HMGB1, immunomodulatory effect of HMGB1, clinical findings and other potential treatment involving HMGB1, and role of HMGB1 protein in brain injury. Conclusion HMGB1 has a strong pro-inflammation property which predominantly acts through RAGE pathways.Review registration number reviewregistry966 in www.researchregistry.com .

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Molecular Impact on High Motility Group Box-1 (HMGB-1) in Pamps and Damp

Cited by 7 publications

References 0 publications

Linking Interaction between Antimicrobial Peptide and High Motility Group Box-1 (HMBG-1) in Bacterial Infection

Linking Interaction between Antimicrobial Peptide and High Motility Group Box-1 (HMBG-1) in Bacterial Infection

The Role of Herbal Medicine in Suppressing the Incidence of Typhoid Fever in Indonesia

Immunomodulatory properties of high mobility group box 1 and its potential role in brain injury: Review article

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