Molecular Immunology in Hematological Disorders

Takami, Akiyoshi

doi:10.3390/ijms23179584

Cited by 1 publication

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References 13 publications

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“…Apart from human physiological changes caused by disease or exposure to environmental changes, administration of drugs have been linked with changes in haematological parameters. 2,3,4 One of such medication which have been implicated in significant influence of haematological parameters is antiretroviral drug. Aside from the human papillomavirus (HPV), herpes simplex virus (HSV), hepatitis B and C, and human herpesvirus-8 (HHV-8), antiretroviral treatments or therapies (ART) are particularly crucial for HIV therapy.…”

Section: Introductionmentioning

confidence: 99%

Pattern of Haematological Indices of Wistar Rats Administered Antiretroviral Therapy Singly or in Combination with Ascorbic Acid and α-Tocopherol

2024

TJNPR

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Antiretroviral therapy use in the treatment of HIV/AIDS, has previously been linked to anaemia or a decrease in haematologic performance. Given that HIV/AIDS has a significant impact on immune responses, using antioxidants in the treatment of these disease may improve immunological outcomes, as evidenced by haematologic indices. This investigation sought to ascertain the haematological response of Wistar arts treated orally with Lamivudine and Zidovudine along with Vitamins C and E. For 90 days, Wistar rats were given Zidovudine and Lamivodine orally along with vitamin C and E supplements. The rats were divided into groups: one group received Zidovudine and Lamivudine orally at a dose of 15 mg Zidovudine/kg/body and 7.5 mg Lamivudine/kg BW. Vitamin E was also administered at 25 IU/kg BW; the same dose was administered for Vitamin C. The other group received a combination of the antiretroviral drug (ARD) and an antioxidant. The last (or control) group received distilled water at 10ml/kg. At the end of the treatment , the Wistar rats were humanly sacrificed and whole blood collected into Ethylene Diamine tetraacetic acid containers for analysis of haematological indices. The effects of the antiretroviral therapy on red blood indices varied with the ARD administered; there was a significant increase in haematocrit levels in Lamivudine-treated Wistar rats (p<0.05). The results also revealed that lymphocyte concentration was more likely to be related with Lamivudine+Vitamin E treatment than with Lamivudine administration alone. Similarly, the combination of Zidovudine and Vitamin C was more likely to impact platelet count concentrations than Zidovudine alone.

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Section: Introductionmentioning

confidence: 99%

Pattern of Haematological Indices of Wistar Rats Administered Antiretroviral Therapy Singly or in Combination with Ascorbic Acid and α-Tocopherol

2024

TJNPR

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Molecular Immunology in Hematological Disorders

Abstract: This Special Issue aims to highlight the molecular mechanisms involved in the development and progression of hematologic malignancies such as leukemia, lymphoma, and myeloma [...]

Cited by 1 publication

References 13 publications

Pattern of Haematological Indices of Wistar Rats Administered Antiretroviral Therapy Singly or in Combination with Ascorbic Acid and α-Tocopherol

Pattern of Haematological Indices of Wistar Rats Administered Antiretroviral Therapy Singly or in Combination with Ascorbic Acid and α-Tocopherol

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