Molecular imaging with optics: primer and case for near-infrared fluorescence techniques in personalized medicine

Sevick‐Muraca, Eva M.; Rasmussen, John C.

doi:10.1117/1.2953185

Cited by 105 publications

(102 citation statements)

References 63 publications

(74 reference statements)

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“…The many applications of ICG-enhanced fluorescence imaging in guided surgical procedures include intraoperative angiography, laparoscopic cholecystectomy, extrahepatic cholangiography, colorectal resection, living-donor nephrectomy, laparoscopic kidney autotransplantation, lymph node mapping and dissection, and various other procedures (9,20,21). Indocyanine green-enhanced fluorescence imaging is now well established as simple, inexpensive, and effective (1)(2)(3)(4)(5)(6)(7)(8) and is expected to become a standard technique for many diagnostic and oncological purposes in the near future. However, further large scale studies are needed to clarify its specific advantages and disadvantages in large populations.…”

Section: Icg-enhanced Fluorescence Imaging In Surgerymentioning

confidence: 99%

“…Injected ICG binds tightly to lipoproteins and is rapidly excreted into the bile (1)(2)(3)(4)(5)(6)(7)(8).…”

Section: Review Articlementioning

confidence: 99%

“…Indocyanine green-enhanced fluorescence for assessing parathyroid perfusion during thyroidectomy of visceral blood supply and evaluation of bowel perfusion (1)(2)(3)(4)(5)(6)(7)(8)(9). Injected ICG binds tightly to lipoproteins and is rapidly excreted into the bile (1)(2)(3)(4)(5)(6)(7)(8).…”

Section: Review Articlementioning

confidence: 99%

“…Indocyanine green is a water-soluble anionic amphiphilic tricarbocyanine dye with a molecular weight of 774.96 Da (1)(2)(3)(4)(5)(6)(7)(8)(9). This dye can be injected into the human bloodstream with practically no adverse effects (10)(11)(12)(13)(14)(15)(16)(17)(18)(19) and becomes fluorescent upon excitation by a laser beam or by light with a wavelength in the near infra-red (NIR) spectrum (approximately 820 nm).…”

Section: Introductionmentioning

confidence: 99%

“…Recently, indocyanine green (ICG)-enhanced fluorescence has been used to improve visualization and to provide detailed anatomical information during different surgical procedures, especially laparoscopic surgery (1)(2)(3)(4)(5)(6)(7)(8). Fluorescent optical guidance minimizes inadvertent tissue injury while enhancing procedural efficiency (9).…”

Section: Introductionmentioning

confidence: 99%

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Indocyanine green-enhanced fluorescence for assessing parathyroid perfusion during thyroidectomy

Lavazza

Liu

et al. 2016

Gland Surg.

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Identification of the parathyroid glands during thyroid surgery may prevent their inadvertent surgical removal and thus provide a better postoperative quality of life. Nevertheless, the most common "technique" for intraoperative evaluation of perfusion of parathyroid gland tissues during thyroid surgery is visual inspection of the physical condition of tissues, e.g., their color and bleeding edges. Another technique is measurement of intact parathyroid hormone. Recently, indocyanine green-enhanced fluorescence has been used in various surgical techniques, particularly laparoscopic surgery, to improve visualization and to provide detailed anatomical information. Fluorescent optical guidance helps surgeons to avoid inadvertent tissue injury while enhancing procedural efficiency. This technique has potential use for evaluating perfusion of the parathyroid gland in real-time intraoperative angiography.

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Section: Icg-enhanced Fluorescence Imaging In Surgerymentioning

confidence: 99%

“…Injected ICG binds tightly to lipoproteins and is rapidly excreted into the bile (1)(2)(3)(4)(5)(6)(7)(8).…”

Section: Review Articlementioning

confidence: 99%

Section: Review Articlementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Indocyanine green-enhanced fluorescence for assessing parathyroid perfusion during thyroidectomy

Lavazza

Liu

et al. 2016

Gland Surg.

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Current trends and emerging future of indocyanine green usage in surgery and oncology

Połom

Murawa

Rho

et al. 2011

Cancer

231

172

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Ever since Kitai first performed fluorescent navigation of sentinel lymph nodes (SLNs) using indocyanine green (ICG) dye with a charge-couple device and light emitting diodes, the intraoperative use of near infrared fluorescence has served a critical role in increasing our understanding in various fields of surgical oncology. Here the authors review the emerging role of the ICG fluorophore in the development of our comprehension of the lymphatic system and its use in SLN mapping and biopsy in various cancers. In addition, they introduce the novel role of ICG-guided video angiography as a new intraoperative method of assessing microvascular circulation. The authors attempt to discuss the promising potential in addition to assessing several challenges and limitations in the context of specific surgical procedures and ICG as a whole. PubMed and Medline literature databases were searched for ICG use in clinical surgical settings. Despite ICG's significant impact in various fields of surgical oncology, ICG is still in its nascent stages, and more in-depth studies need to be carried out to fully evaluate its potential and limitations. Cancer 2011;117:4812-22. V C 2011 American Cancer Society.KEYWORDS: sentinel lymph node, indocyanine green, lymphedema, free flaps, axillary reverse mapping, sentinel lymph node biopsy.Near infrared (NIR; emission spectra of $700-850 nm) 1 fluorophores are probes that have gained immense interest in various fields of biomedicine because of their minimal interfering absorption and fluorescence from biological samples, inexpensive laser diode excitation, reduced scattering, and enhanced tissue penetration depth. 2 However, to date, only 1 NIR probe, indocyanine green (ICG) has been approved by the US Food and Drug Administration (FDA); methylene blue is another FDA-approved probe that displays NIR properties, however, it is not considered a pure NIR probe. The former, ICG, is a water-soluble, anionic, amphiphilic tricarbocyanine probe 3 with a hydrodynamic diameter of 1.2 nm, and excitation and emission wavelengths in serum at 778 and 830, respectively. 4,5 For several years, it has been used in ophthalmic angiography 6 and for determining cardiac output 7 and hepatic function. 8 However, it has only recently shown real practicability and feasibility in the field of surgical oncology. Three major domains where NIR-guided ICG fluorophores have appeared most promising are: 1) sentinel lymph node (SLN) detection, 2) evaluation of lymphedema, and 3) assessment of microvascular circulation of free flaps in reconstructive surgery. Although several reviews have discussed the importance of NIR fluorophores (including ICG), 9-13 in this review we limit our discussion specifically to ICG in an attempt to attain a better understanding of its impact and challenges it presents in the field of surgical oncology.Intraoperative SLN Mapping and Biopsy Using ICG The significance of cancer treatment management in relation to first lymphatic drainage from the tumor site, the SLN, was first proposed by Cabanas...

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Sensitivity and accuracy of hybrid fluorescence‐mediated tomography in deep tissue regions

Rosenhain

Rawashdeh

Kießling

et al. 2016

Journal of Biophotonics

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Fluorescence-mediated tomography (FMT) enables noninvasive assessment of the three-dimensional distribution of near-infrared fluorescence in mice. The combination with micro-computed tomography (µCT) provides anatomical data, enabling improved fluorescence reconstruction and image analysis. The aim of our study was to assess sensitivity and accuracy of µCT-FMT under realistic in vivo conditions in deeply-seated regions. Accordingly, we acquired fluorescence reflectance images (FRI) and µCT-FMT scans of mice which were prepared with rectal insertions with different amounts of fluorescent dye. Default and high-sensitivity scans were acquired and background signal was analyzed for three FMT channels (670 nm, 745 nm, and 790 nm). Analysis was performed for the original and an improved FMT reconstruction using the µCT data. While FRI and the original FMT reconstruction could detect 100 pmol, the improved FMT reconstruction could detect 10 pmol and significantly improved signal localization. By using a finer sampling grid and increasing the exposure time, the sensitivity could be further improved to detect 0.5 pmol. Background signal was highest in the 670 nm channel and most prominent in the gastro-intestinal tract and in organs with high relative amounts of blood. In conclusion, we show that µCT-FMT allows sensitive and accurate assessment of fluorescence in deep tissue regions.

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Molecular imaging with optics: primer and case for near-infrared fluorescence techniques in personalized medicine

Cited by 105 publications

References 63 publications

Indocyanine green-enhanced fluorescence for assessing parathyroid perfusion during thyroidectomy

Indocyanine green-enhanced fluorescence for assessing parathyroid perfusion during thyroidectomy

Current trends and emerging future of indocyanine green usage in surgery and oncology

Sensitivity and accuracy of hybrid fluorescence‐mediated tomography in deep tissue regions

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