Molecular Imaging of Tumor Angiogenesis

McDermott, Shaunagh; Guimaraes, Alexander S. R.

doi:10.5772/32202

Cited by 1 publication

(1 citation statement)

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“…These new emerging agents are obtained by binding marker molecules (peptides, proteins, and antibodies) to the imaging agent to specifically target molecular expression of angiogenesis [265], [266], [267], [268]. Typical molecular targets include VEGF receptors, key regulators of angiogenesis and vasculogenesis, and α V β 3 integrin, cell adhesion molecule mediating the migration of endothelial cells through the basement membrane during blood-vessel formation [269]. Contrast agents decorated with angiogenesis-targeting ligands remain attached to the areas in which the target molecule is upregulated, thus causing selective enhancement in DCE images, especially in the late phase after injection [266].…”

Section: Recommendations and Outlookmentioning

confidence: 99%

Mathematical Models of Contrast Transport Kinetics for Cancer Diagnostic Imaging: A Review

Turco

Wijkstra

Mischi

2016

IEEE Rev. Biomed. Eng.

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Angiogenesis plays a fundamental role in cancer growth and the formation of metastasis. Novel cancer therapies aimed at inhibiting angiogenic processes and/or disrupting angiogenic tumor vasculature are currently being developed and clinically tested. The need for earlier and improved cancer diagnosis, and for early evaluation and monitoring of therapeutic response to angiogenic treatment, have led to the development of several imaging methods for in vivo noninvasive assessment of angiogenesis. The combination of dynamic contrast-enhanced imaging with mathematical modeling of the contrast agent kinetics enables quantitative assessment of the structural and functional changes in the microvasculature that are associated with tumor angiogenesis. In this paper, we review quantitative imaging of angiogenesis with dynamic contrast-enhanced magnetic resonance imaging, computed tomography, and ultrasound.

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