Molecular Imaging of the Cardiac Extracellular Matrix

Inhibition of Pin1 alleviates myocardial fibrosis and dysfunction in STZ-induced diabetic mice

“…This finding may contribute to the development of treatments targeting cardiac remodeling and cardiac dysfunction in diabetes. MMPs belong to the family of zinc containing endopeptidases, which play critical roles in regulating ECM deposition and degradation, contributing to the process of cardiac remodeling and fibrosis [30]. Importantly, increased levels of MMP-9 and MMP-2 activity are involved in matrix degradation in the diabetic heart leading to fibrosis [31,32].…”

Novel plasma and imaging biomarkers in heart failure with preserved ejection fraction

“…Although most studies have employed nuclear techniques (limited signal from poor tissue penetration), hybrid imaging with PET, SPECT, CT or CMR may further improve spatial resolution, which is the current major limitation. Cost and limited radiotracer availability are additional factors [98].…”

Atrial Structure and Function and its Implications for Current and Emerging Treatments for Atrial Fibrillation

“…This technique has been demonstrated in animal ventricular models 135 and its role in detecting atrial fibrosis and remodelling is a subject of ongoing research. Direct incorporation of spatial fibrosis data into exiting 3D mapping systems may help guide ablation procedures and improve outcome in the future.…”