Molecular Imaging of the Cardiac Extracellular Matrix

Haas, Hans J. de; Arbustini, Eloisa; Fuster, Valentin; Kramer, Christopher M.; Narula, Jagat

doi:10.1161/circresaha.113.302680

Cited by 66 publications

(51 citation statements)

References 122 publications

(123 reference statements)

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“…This finding may contribute to the development of treatments targeting cardiac remodeling and cardiac dysfunction in diabetes. MMPs belong to the family of zinc containing endopeptidases, which play critical roles in regulating ECM deposition and degradation, contributing to the process of cardiac remodeling and fibrosis [30]. Importantly, increased levels of MMP-9 and MMP-2 activity are involved in matrix degradation in the diabetic heart leading to fibrosis [31,32].…”

Section: Discussionmentioning

confidence: 99%

Inhibition of Pin1 alleviates myocardial fibrosis and dysfunction in STZ-induced diabetic mice

Liu

Liang

Song³

et al. 2016

Biochemical and Biophysical Research Communications

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“…Although most studies have employed nuclear techniques (limited signal from poor tissue penetration), hybrid imaging with PET, SPECT, CT or CMR may further improve spatial resolution, which is the current major limitation. Cost and limited radiotracer availability are additional factors [98].…”

Section: Novel Imaging Biomarkersmentioning

confidence: 99%

Novel plasma and imaging biomarkers in heart failure with preserved ejection fraction

Kanagala

Squire

et al. 2015

IJC Heart & Vasculature

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Existing diagnostic guidelines for heart failure with preserved ejection fraction (HFPEF) primarily comprise natriuretic peptides and echocardiographic assessment, highlighting the role of diastolic dysfunction. However, recent discoveries of novel plasma markers implicated in pathophysiology of heart failure and technological advances in imaging provide additional biomarkers which are potentially applicable to HFPEF. The evidence base for plasma extra-cellular matrix (ECM) peptides, galectin-3, ST2, GDF-15 and pentraxin-3 is reviewed. Furthermore, the capabilities of novel imaging techniques to assess existing parameters (e.g. left ventricular ejection fraction, systolic & diastolic function, chamber size) and additional derangements of the ECM, myocardial mechanics and ischaemia evaluation are addressed.

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“…This technique has been demonstrated in animal ventricular models 135 and its role in detecting atrial fibrosis and remodelling is a subject of ongoing research. Direct incorporation of spatial fibrosis data into exiting 3D mapping systems may help guide ablation procedures and improve outcome in the future.…”

Section: Limitations In Detecting Structural Remodellingmentioning

confidence: 99%

Atrial Structure and Function and its Implications for Current and Emerging Treatments for Atrial Fibrillation

Prabhu¹,

McLellan²,

Walters

et al. 2015

Progress in Cardiovascular Diseases

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“…192 These “myofibroblasts” (Fig. 9.1, top) experience calcium-dependent contractility, 193 elevated ECM deposition, 171,194 and influence cardiac conduction. 186,195 Increased substrate stiffness can also increase differentiation of fibroblasts into myofibroblasts, 196–198 suggesting a positive feedback loop following ECM deposition.…”

Section: Ecm and Mechanosensingmentioning

confidence: 99%

From Stem Cells to Cardiomyocytes

Kaushik

Engler

2014

Progress in Molecular Biology and Translational Science

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Stem cell differentiation into a variety of lineages is known to involve signaling from the extracellular niche, including from the physical properties of that environment. What regulates stem cell responses to these cues is there ability to activate different mechanotransductive pathways. Here, we will review the structures and pathways that regulate stem cell commitment to a cardiomyocyte lineage, specifically examining proteins within muscle sarcomeres, costameres, and intercalated discs. Proteins within these structures stretch, inducing a change in their phosphorylated state or in their localization to initiate different signals. We will also put these changes in the context of stem cell differentiation into cardiomyocytes, their subsequent formation of the chambered heart, and explore negative signaling that occurs during disease.

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“…ECM imaging is a still-developing field currently defined by the divide between invasive and noninvasive imaging methods [25, 74]. Invasive imaging methods are dominated by microscopy-based applications and are the gold standard for measuring the ECM, but they are limited in their clinical application.…”

Section: Introductionmentioning

confidence: 99%

Imaging the Cardiac Extracellular Matrix

Pinkert

Hortensius

Ogle

et al. 2018

Advances in Experimental Medicine and Biology

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Cardiovascular disease is the global leading cause of death. One route to address this problem is using biomedical imaging to measure the molecules and structures that surround cardiac cells. This cellular microenvironment, known as the cardiac extracellular matrix, changes in composition and organization during most cardiac diseases and in response to many cardiac treatments. Measuring these changes with biomedical imaging can aid in understanding, diagnosing, and treating heart disease. This chapter supports those efforts by reviewing representative methods for imaging the cardiac extracellular matrix. It first describes the major biological targets of ECM imaging, including the primary imaging target of fibrillar collagen. Then it discusses the imaging methods, describing their current capabilities and limitations. It categorizes the imaging methods into two main categories: organ-scale noninvasive methods and cellular-scale invasive methods. Noninvasive methods can be used on patients, but only a few are clinically available, and others require further development to be used in the clinic. Invasive methods are the most established and can measure a variety of properties, but they cannot be used on live patients. Finally, the chapter concludes with a perspective on future directions and applications of biomedical imaging technologies.

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Molecular Imaging of the Cardiac Extracellular Matrix

Cited by 66 publications

References 122 publications

Inhibition of Pin1 alleviates myocardial fibrosis and dysfunction in STZ-induced diabetic mice

Novel plasma and imaging biomarkers in heart failure with preserved ejection fraction

Atrial Structure and Function and its Implications for Current and Emerging Treatments for Atrial Fibrillation

From Stem Cells to Cardiomyocytes

Imaging the Cardiac Extracellular Matrix

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