Molecular Imaging of Pituitary Tumors

Gillett, Daniel; MacFarlane, James; Bashari, Waiel; Crawford, Rosy; Harper, Ines; Mendichovszky, Iosif; Aloj, Luigi; Cheow, Heok; Gurnell, Mark

doi:10.1053/j.semnuclmed.2023.02.005

Cited by 5 publications

(1 citation statement)

References 53 publications

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“…Recently, several radioligands have been developed: functional pituitary imaging can confirm a suspected microadenoma or reveal a previously unsuspected one [62]. The modern functional pituitary imaging is predominantly performed using PET, due to the limited spatial resolution of gamma cameras, reflecting its superior spatial resolution compared to SPECT.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Subtyping of Cushing’s Syndrome: A Step Ahead

Tizianel,

Barbot,

Ceccato

2024

Exp Clin Endocrinol Diabetes

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Cushing’s Syndrome (CS) is a rare disease due to chronic endogenous cortisol secretion. In the last years, new acquisitions enlarged the spectrum of differential diagnosis, historically divided into ACTH-dependent and ACTH-independent forms. Moreover, the increased awareness of the detrimental cortisol effects on cardiometabolic health and the risk of cardiovascular events lead to increased diagnosis of mild forms, especially in the context of adrenal incidentalomas. We provide and up-to-date narrative review of the most recent literature regarding the challenges of CS diagnosis. After the description of the diagnostic tools available, we describe the characterization of functional non-neoplastic hypercortisolism (formerly known as pseudo-Cushing state), then we report the subtyping of the different conditions of hypercortisolism: the differential diagnosis of ACTH-dependent forms and the management of adrenal hypercortisolism, with peculiar attention to the new genetic classification of adrenal CS, mild autonomous cortisol secretion and bilateral adrenal adenomas.

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Section: Accepted Manuscriptmentioning

confidence: 99%

Subtyping of Cushing’s Syndrome: A Step Ahead

Tizianel,

Barbot,

Ceccato

2024

Exp Clin Endocrinol Diabetes

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EANM position on positron emission tomography in suspected functional pituitary neuroendocrine tumours

Van Weehaeghe,

Lapauw,

Fraioli

et al. 2024

Eur J Nucl Med Mol Imaging

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Endocrinology application of molecular imaging: current role of PET/CT

Calderoni,

Giovanella,

Fanti

2024

J Endocrinol Invest

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Background In recent years, nuclear medicine imaging methods have proven to be of paramount importance in a wide variety of diseases, particularly in oncology, where they are crucial for assessing the extent of disease when conventional methods fall short. Moreover, nuclear imaging modalities are able to better characterize lesions using target agents related to specific pathways (e.g. glucose metabolism, cellular proliferation, amino acid transport, lipid metabolism, specific receptor ligands). The clinical presentation of endocrine diseases encompasses a broad spectrum of sign and symptoms. Moreover, endocrine tumors show varying degrees of aggressiveness from well differentiated and indolent to highly aggressive cancers, respectively. Rationale With the application of new medicinal radio-compounds and increasingly advanced tomographic imaging technology, the utility of Positron Emission Tomography/Computed Tomography (PET/CT) in the field of endocrine diseases is expanding. Aim This review aims to analyze and summarize the primary indications of PET/CT, providing a practical approach for clinicians. A comprehensive literature search on PubMed was conducted to provide an updated overview of the available evidence regarding the use of PET/CT in endocrinology. Within this review, we will discuss the applications of PET/CT, compare different radiopharmaceuticals and highlight the uptake mechanism, excluding neuroendocrine carcinomas from discussion. Conclusions PET/CT is a valuable tool in diagnosing and managing endocrine disorders due to its capacity to furnish both functional and anatomical information, facilitate early lesion detection, guide treatment decisions, and monitor treatment response. Its non-invasive nature and precision make it an integral component of modern endocrine healthcare. This review aims to provide physicians with a clear perspective on the role of PET/CT imaging, discussing its emerging opportunities and appropriateness of use in endocrinological diseases.

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Molecular Imaging of Pituitary Tumors

Cited by 5 publications

References 53 publications

Subtyping of Cushing’s Syndrome: A Step Ahead

Subtyping of Cushing’s Syndrome: A Step Ahead

EANM position on positron emission tomography in suspected functional pituitary neuroendocrine tumours

Endocrinology application of molecular imaging: current role of PET/CT

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