Molecular Imaging of Infectious Diseases

Rolle, Anna-Maria; Wiehr, Stefan

doi:10.1007/978-3-319-42202-2_34

Cited by 1 publication

(1 citation statement)

References 69 publications

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“…Despite the abilities of mAbs to differentiate different genera and species of human pathogenic fungi, and their capacity to discriminate between inactive spores and invasive hyphae ( Thornton and Wills, 2015 ), their use in molecular imaging of IFDs has yet to be fully realized. Imaging with antibodies has, until very recently, been the domain of cancer detection ( Mestel, 2017 ), with limited application in infectious disease diagnostics ( Rolle and Wiehr, 2017 ). However, recent studies have demonstrated the enormous potential of antibody-guided PET/MRI (immunoPET/MRI) technologies to dramatically improve the molecular imaging of viral ( Santangelo et al, 2014 ), bacterial ( Wiehr et al, 2016 ), and fungal ( Rolle et al, 2016 ; Davies et al, 2017 ) infections in vivo , with the real possibility of precision medicine for infectious diseases in the near future ( Jain, 2017 ).…”

Section: Aspergillosis Imaging With Monoclonal Antibody Jf5mentioning

confidence: 99%

Molecular Imaging of Invasive Pulmonary Aspergillosis Using ImmunoPET/MRI: The Future Looks Bright

Thornton

2018

Front. Microbiol.

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Invasive pulmonary aspergillosis (IPA) is a life-threatening lung disease of immuno-compromised humans caused by the ubiquitous environmental mold Aspergillus. Biomarker tests for the disease lack sensitivity and specificity, and culture of the fungus from invasive lung biopsy is slow, insensitive, and undesirable in critically ill patients. A computed tomogram (CT) of the chest offers a simple non-intrusive diagnostic procedure for rapid decision making, and so is used in many hematology units to drive antifungal treatment. However, radiological indicators that raise the suspicion of IPA are either transient signs in the early stages of the disease or not specific for Aspergillus infection, with other angio-invasive molds or bacterial pathogens producing comparable radiological manifestations in a chest CT. Improvements to the specificity of radiographic imaging of IPA have been attempted by coupling CT and positron emission tomography (PET) with [18F]fluorodeoxyglucose ([18F]FDG), a marker of metabolic activity well suited to cancer imaging, but with limited use in invasive fungal disease diagnostics due to its inability to differentiate between infectious etiologies, cancer, and inflammation. Bioluminescence imaging using single genetically modified strains of Aspergillus fumigatus has enabled in vivo monitoring of IPA in animal models of disease. For in vivo detection of Aspergillus lung infections in humans, radiolabeled Aspergillus-specific monoclonal antibodies, and iron siderophores, hold enormous potential for clinical diagnosis. This review examines the different experimental technologies used to image IPA, and recent advances in state-of-the-art molecular imaging of IPA using antibody-guided PET/magnetic resonance imaging (immunoPET/MRI).

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Section: Aspergillosis Imaging With Monoclonal Antibody Jf5mentioning

confidence: 99%

Molecular Imaging of Invasive Pulmonary Aspergillosis Using ImmunoPET/MRI: The Future Looks Bright

Thornton

2018

Front. Microbiol.

View full text Add to dashboard Cite

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Molecular Imaging of Infectious Diseases

Cited by 1 publication

References 69 publications

Molecular Imaging of Invasive Pulmonary Aspergillosis Using ImmunoPET/MRI: The Future Looks Bright

Molecular Imaging of Invasive Pulmonary Aspergillosis Using ImmunoPET/MRI: The Future Looks Bright

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