Molecular Imaging of Bacteria in Patients Is an Attractive Fata Morgana, Not a Realistic Option

Hess, Søren; Alavi, Abass; Werner, Tom; Høilund‐Carlsen, Poul Flemming

doi:10.2967/jnumed.117.207001

Cited by 7 publications

(6 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Over the past three decades, efforts have been made to develop single-photon emission computerized tomography (SPECT) and PET tracers that will target bacteria, and therefore, differentiate between pure inflammation and infectious disorders [ 10 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 ]. In contrast to imaging techniques such as CT and MRI, the spatial resolution of PET imaging is still suboptimal for portraying details related to targeted structures, despite significant advances that have been made in recent years.…”

Section: Limitations Of Pet For Direct Visualization Of Bacteriamentioning

confidence: 99%

“…In order to detect microscopic structures such as bacteria at the sites of infection, realistically, it would be necessary to accumulate a large volume in the range of 8–10 cubic mm for detection by PET imaging. Furthermore, the concentration of imaging agents by these microorganisms should be significantly higher than that of the background to reach appropriate contrast compared to surrounding background activity [ 7 , 66 , 73 , 74 , 75 , 76 ].…”

Section: Limitations Of Pet For Direct Visualization Of Bacteriamentioning

confidence: 99%

“…This phenomenon will be an ongoing process in most bacterial infections. Therefore, it is unlikely that a large volume of bacteria will be exposed to the radiotracers that have been successfully synthesized based on in vitro testing [ 66 , 74 , 77 ].…”

Section: Limitations Of Pet For Direct Visualization Of Bacteriamentioning

confidence: 99%

See 2 more Smart Citations

Is Imaging Bacteria with PET a Realistic Option or an Illusion?

et al. 2023

Self Cite

View full text Add to dashboard Cite

The application of [18F]-fluorodeoxyglucose ([18F]FDG) as a radiotracer to detect sites of inflammation (either due to bacterial infection or primary inflammation) has led to exploring the role of PET in visualizing bacteria directly at sites of infection. However, the results from such efforts are controversial and inconclusive so far. We aimed to assess the limitations of PET as an effective modality in the diagnosis of bacterial infections. Inflammation due to bacterial infections can be visualized by using [18F]FDG-PET. However, the non-specificity of [18F]FDG makes it undesirable to visualize bacteria as the underlying cause of inflammation. Hence, more specific radiotracers that possibly bind to or accumulate in bacteria-specific receptors or enzymes are being explored. Several radiotracers, including 2-deoxy-2-[18F]fluorosorbitol ([18F]FDS), 6-[18F]-fluoromaltose, [11C]para-aminobenzoic acid ([11C]PABA), radiolabeled trimethoprim (11C-TMP) and its analog fluoropropyl-trimethoprim (18F-FPTMP), other radiolabeled sugars, and antimicrobial drugs have been used to image microorganisms. Unfortunately, no progress has been made in translating the results to routine human use; feasibility and other factors have constrained their success in clinical settings. In the current article, we discuss the limitations of direct bacterial visualization with PET tracers, but emphasize the important role of [18F]FDG-PET as the only option for detecting evidence of infection.

show abstract

Section: Limitations Of Pet For Direct Visualization Of Bacteriamentioning

confidence: 99%

Section: Limitations Of Pet For Direct Visualization Of Bacteriamentioning

confidence: 99%

See 1 more Smart Citation

Is Imaging Bacteria with PET a Realistic Option or an Illusion?

et al. 2023

Self Cite

View full text Add to dashboard Cite

show abstract

“…Spesifik bakteri görüntülemenin zorlukları vardır. Bu zorluklar bazı yayınlanmış mektup ve görüşlerle ifade edilmiş, hatta bazı yazarlar elde edilecek sonuçların bu çabaya değmeyeceğini öne sürmüşlerdir (37). Bakterilere özgü araştırmalarda farklı görüntüleme yöntemleri kullanılmaktadır (PET, SPECT ve optik görüntüleme).…”

Section: Spesifikbakteriyelgörüntülemedepotansiyel Yenigörüntülemeajaunclassified

Infection Models and Imaging Techniques Used in Preclinical Studies

Gültekin¹,

Üstün²

2019

nts

View full text Add to dashboard Cite

show abstract

“…Specific bacteria imaging has its challenges. These challenges have been expressed in some published letters and opinions with some even suggesting it is not worth the effort [51,52]. Studies condusted by other researchers have showed however that bacteriaspecific imaging is beneficial with some tracers being singled out as more favorable candidates [53][54][55].…”

Section: Potential New Imaging Agents To Selectively Image Bacterial mentioning

confidence: 99%

New Imaging Tracers for the Infected Diabetic Foot (Nuclear and Optical Imaging)

Ankrah

Klein

Elsinga

2018

CPD

View full text Add to dashboard Cite

Diabetic Foot Infections (DFIs) are associated with increased morbidity, an economic burden on patients, their families and healthcare systems and increased mortality. Early diagnosis with prompt, appropriate and adequate treatment of the infected diabetic foot is crucial. The determination of DFIs, however, may be quite perplexing and invasive. Imaging is useful in the evaluation of certain cases of DFIs, especially in suspected instances with no overt clinical features, or in the diagnosis of osteomyelitis. Nuclear medicine imaging is currently used in the evaluation of DFIs; however, like all the imaging techniques now available, it has its limitations. Several radiopharmaceuticals presently available play useful roles in the management of DFIs, while new ones are being evaluated. Optical imaging techniques have recently demonstrated promising results in the evaluation of many infections including DFIs. Using the same molecule, a tracer can be labeled with a radioisotope or an optical imaging dye. This enables infections to be evaluated both pre- and intra-operatively when surgery is required in their management. In some cases, tracers have been simultaneously labeled with both a radioisotope and an optical imaging dye to produce a hybrid tracer. These new tracers potentially provide powerful and new opportunities in the management of DFIs. In this review, we briefly examine tracers that have been used in the evaluation of the infected diabetic foot. We then explore the potential of new imaging tracers currently under development for infection that may be useful in the management of DFIs.

show abstract

Molecular Imaging of Bacteria in Patients Is an Attractive Fata Morgana, Not a Realistic Option

Abstract: Final results of a prospective evaluation of the predictive value of interim positron emission tomography in patients with diffuse large b-cell lymphoma treated with R-CHOP-14 (SAKK 38/07).

Cited by 7 publications

References 10 publications

Is Imaging Bacteria with PET a Realistic Option or an Illusion?

Is Imaging Bacteria with PET a Realistic Option or an Illusion?

Infection Models and Imaging Techniques Used in Preclinical Studies

New Imaging Tracers for the Infected Diabetic Foot (Nuclear and Optical Imaging)

Contact Info

Product

Resources

About