Molecular identification and virological characteristics of highly pathogenic avian influenza A/H5N5 virus in wild birds in Egypt

Kandeil, Ahmed; Kayed, Ahmed S.; Moatasim, Yassmin; Aboulhoda, Basma Emad; Taweel, Ahmed N. El; Kutkat, Omnia; Sayes, Mohamed El; Gomaa, Mokhtar R.; El‐Shesheny, Rabeh; Webby, Richard J.; Kayali, Ghazi; Ali, Mohamed A.

doi:10.1016/j.micpath.2022.105928

Microbial Pathogenesis

2023

DOI: 10.1016/j.micpath.2022.105928

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Molecular identification and virological characteristics of highly pathogenic avian influenza A/H5N5 virus in wild birds in Egypt

Ahmed Kandeil

Ahmed S. Kayed

Yassmin Moatasim

et al.

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Cited by 4 publications

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“…During 2021, the HPAI H5N8 virus was reported for the first time in humans who have a history of contact with infected poultry in Russia (WHO, 2021). Moreover, HPAI (H5N1) and (H5N5) belonging to clade 2.3.4.4b has been detected recently in Egypt at migratory birds (Mosaad et al, 2023& Kandeil et al, 2023 which may lead to further complication of AI disease situation in Egypt. The controlling of AI infections in Egypt depends mainly on vaccination as a routine control strategy to minimize losses in poultry production by limiting the spread of infection.…”

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confidence: 99%

Appraisal of Three Commercial Inactivated Avian Influenza Vaccines Efficacy Against Challenge with Egyptian Duck-Origin Clade 2.3.4.4b H5N8 in Commercial Broiler Chickens

Hamdy,

Arafa,

Gaballa

et al. 2024

Journal of Current Veterinary Research

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The highly pathogenic avian influenza (HPAI) H5N8 virus belonging to clade 2.3.4.4b was detected in Egypt during 2016, which is one of the few countries depends on vaccination as a main control strategy. This study was conducted to assess the efficacy of three different commercial inactivated AI vaccines of different clades (clade 1, clade 2.3.4.4b and (Re-6 & Re-8)) in commercial broiler chickens against HPAI H5N8 clade 2.3.4.4b.The clinical protection percent was 67%, 80% and 87% in G1 (clade 1), G2 (clade 2.3.4.4b), and G3 (Re-6 & Re-8), respectively. The lowest mean antibody titer was recorded in G1 which exhibited unsatisfactory level of immune response. Also, Antisera raised against clade 1 vaccine showed minimal reactivity with clade 2.3.4.4b and Re-6&Re-8antigens suggesting poor cross-protection. This was reflected on the antigenic relatedness (R-value) which was low (11.3%) indicating major antigenic difference. Samples were collected for examination of histopathological changes from thymus, trachea, spleen, bursa of Fabricius, lung, and cerebrum. Only mild cerebrum lesions were found in all challenged groups indicating reduced neurotropism. In lymphoid tissues, moderate to severe lesion score were detected. This impairment effect on some bird immune organs highlight the immunosuppressive effect of the virus, which can appear in the vaccinated exposed birds to HPAI virus. It is recommended to update the vaccine seed strains to be closely related to the circulating field strains to obtain better protection levels. Also, continuous evaluation of the validated AI vaccines against recent field strains is substantial.

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confidence: 99%

Appraisal of Three Commercial Inactivated Avian Influenza Vaccines Efficacy Against Challenge with Egyptian Duck-Origin Clade 2.3.4.4b H5N8 in Commercial Broiler Chickens

Hamdy,

Arafa,

Gaballa

et al. 2024

Journal of Current Veterinary Research

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Genetic and virological characteristics of a reassortant avian influenza A H6N1 virus isolated from wild birds at a live-bird market in Egypt

Kutkat,

Gomaa,

Aboulhoda

et al. 2024

Arch Virol

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Unveiling 1,3-Thiazine Derivative as a Potential Neuraminidase Inhibitor: Molecular Docking, Molecular Dynamics, ADMET and DFT Studies

et al. 2023

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Molecular identification and virological characteristics of highly pathogenic avian influenza A/H5N5 virus in wild birds in Egypt

Cited by 4 publications

References 22 publications

Appraisal of Three Commercial Inactivated Avian Influenza Vaccines Efficacy Against Challenge with Egyptian Duck-Origin Clade 2.3.4.4b H5N8 in Commercial Broiler Chickens

Appraisal of Three Commercial Inactivated Avian Influenza Vaccines Efficacy Against Challenge with Egyptian Duck-Origin Clade 2.3.4.4b H5N8 in Commercial Broiler Chickens

Genetic and virological characteristics of a reassortant avian influenza A H6N1 virus isolated from wild birds at a live-bird market in Egypt

Unveiling 1,3-Thiazine Derivative as a Potential Neuraminidase Inhibitor: Molecular Docking, Molecular Dynamics, ADMET and DFT Studies

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