In recent years, multiple drug resistance has been developed due to indiscriminate use of existing drugs in the treatment of infectious diseases. One such herbal drug is Coriandrum Sativum L that possesses potential pharmaceutical activities and used in several ayurvedic formulations. Keratitis caused by bacteria, viruses, fungi and parasites. The main goal of this study is to evaluate the antibacterial, antifungal activity, anti-oxidant activity and anti-inflammatory activity of Coriandrum Sativum L leaves and seeds using various organic solvent of plant extract against keratitis disease. The present study carried out the effect on various organic solvents extract of leaves and seeds of Corindrum sativum not only on the bacterial and fungal populations isolated from the conjunctivitis infected eyes but also to screen the phytochemical, anti-inflammatory and in vitro antioxidant potential of the leaf and seed extracts.