Molecular hydrogen reduces acute exercise-induced inflammatory and oxidative stress status

Nogueira, Jonatas E.; Passaglia, Patrícia; Mota, Clarissa M.D.; Santos, Bruna M.; Batalhão, Marcelo Eduardo; Cárnio, Evelin Capellari; Branco, Luiz G.S.

doi:10.1016/j.freeradbiomed.2018.09.028

Cited by 48 publications

(47 citation statements)

References 77 publications

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“…Nogueira et al reported that inhalation of 2% H 2 gas while treadmill running suppresses TBARS levels and inflammatory biomarkers, such as TNF-α and IL-6, in rat plasma immediately or 3 h after exercise [24]. In addition, plasma SOD activity 3 hours after exercise was enhanced by H 2 intake.…”

Section: Inhalation Of H 2 Gasmentioning

confidence: 99%

Application of Molecular Hydrogen as a Novel Antioxidant in Sports Science

Kawamura

Higashida

Muraoka

2020

Oxidative Medicine and Cellular Longevity

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Molecular hydrogen (H2) is a colorless, tasteless, odorless, and minimal molecule with high flammability. Although H2 has been thought to be an inert gas in living bodies for many years, an animal study reported that inhalation of H2 gas decreased oxidative stress and suppressed brain injury caused by ischemia and reperfusion injury due to its antioxidant action. Since then, the antioxidant action of H2 has attracted considerable attention and many studies have reported on its benefits. Most studies have reported the effects of H2 on diseases such as cancer, diabetes, cerebral infarction, and Alzheimer’s disease. However, little is known regarding its effects on healthy subjects and exercise. Thus far, including our study, only 6 studies have explored the effect of H2 on exercise. H2 is the smallest molecule and therefore can easily penetrate the cellular membrane and rapidly diffuse into organelles. H2 is thought to be able to selectively reduce hydroxyl radicals and peroxynitrite and does not affect physiologically reactive species. H2 can be supplied to the body through multiple routes of administration, such as oral intake of H2 water and H2 bathing. Therefore, H2 may be a potential alternative strategy for conventional exogenous antioxidant interventions in sports science. The purpose of this review is to provide evidence regarding the effects of H2 intake on changes in physiological and biochemical parameters, centering on exercise-induced oxidative stress, for each intake method. Furthermore, this review highlights possible future directions in this area of research.

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Section: Inhalation Of H 2 Gasmentioning

confidence: 99%

Application of Molecular Hydrogen as a Novel Antioxidant in Sports Science

Kawamura

Higashida

Muraoka

2020

Oxidative Medicine and Cellular Longevity

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Section: Discussionmentioning

confidence: 99%

“…It has been indicated that intense physical exercises can lead to increased oxidative stress (9,12,13). Multiple studies have also reported that intense physical exercises can lead to increased inflammation in the body (9)(10)(11). Therefore, it is valuable to develop non-invasive approaches to monitor the oxidative stress and inflammation in athletes' body, which may prevent athletes from damage produced by intense exercise-induced oxidative stress and inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…However, intense and prolonged physical exercises may also produce detrimental effect on the body. A number of studies have indicated that intense physical exercises can lead to increased oxidative stress (9,12,13), which may be caused by such factors as mitochondrial electron leakage and NADPH oxidase activity (13). It has also been reported that intense physical exercises can lead to increased inflammation in the body (9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

“…A number of studies have indicated that intense physical exercises can lead to increased oxidative stress (9,12,13), which may be caused by such factors as mitochondrial electron leakage and NADPH oxidase activity (13). It has also been reported that intense physical exercises can lead to increased inflammation in the body (9)(10)(11). In order to prevent athletes from damage produced by intense exercise-induced oxidative stress and inflammation, it is necessary to develop non-invasive approaches to monitor the oxidative stress and inflammation in athletes' body.…”

Section: Introductionmentioning

confidence: 99%

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Professional Swimmers and Normal Populations have Different Patterns of Epidermal Green Autofluorescence

Tao

et al. 2019

Preprint

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Our recent studies have suggested that green autofluorescence of the fingernails and certain regions of skin may be novel biomarkers for disease diagnosis and evaluation of the injury state of cardiovascular system. Our study has also suggested that oxidative stress may produce the increased epidermal green AF by altering keratin 1. Since athletes' body may have increased oxidative stress and inflammation, we proposed our hypothesis that athletes may have increased green AF in their fingernails and certain regions of their skin. In current study we tested this hypothesis by determining the green AF of professional swimmers. We found that compared with age-matched controls, both the green AF intensity and AF asymmetry in both right and left antebrachium and Ventriantebrachium of the professional swimmers is significantly higher. In left Dorsal Centremetacarpus, the green AF intensity of the professional swimmers is significantly higher than that of the age-matched controls. In contrast, the green AF intensity or AF asymmetry of the professional swimmers is not significantly different from that of the age-matched controls in Centremetacarpus, Ventroforefinger, Dorsal Index Finger and Index Fingernails. Collectively, our study has provided first evidence suggesting that athletes have increased green AF intensity and asymmetry in certain regions of their skin. Based on this finding, we may evaluate non-invasively the levels of oxidative damage and inflammation in athletes' body.

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NIR‐II Absorption/Emission Dual Function Based 2D Targeted Nanotheranostics for Tunable Hydrogenothermal Therapy

Li,

Gao,

Wang

et al. 2024

Adv Healthcare Materials

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Photothermal therapy (PTT) is a promising approach for treating tumors that offers multiple advantages. Nevertheless, its practical use in clinical settings faces several limitations, such as suboptimal delivery efficiency, uneven heat distribution, and challenges in predicting optimal treatment duration. In addition, the localized hyperthermia generated by the PTT method to induce cell apoptosis can result in the production of excessive reactive oxygen species (ROS) and the release of inflammatory cytokines, which can pose a threat to the healthy tissues surrounding the tumor. To address the above challenges, we designed an integrated H2 delivery nanoplatform for multimodal imaging H2 thermal therapy. The combination of the second near‐infrared window (NIR‐II) fluorescence imaging (FL) agent (CQ4T) and the photothermal and photoacoustic (PA) properties of Ti3C2 (TC) enables real‐time monitoring of the tumor area and guides photothermal treatment. Simultaneously, due to the acid‐responsive H2 release characteristics of the nanoplatform, H2 can be utilized for synergistic photothermal therapy to eradicate tumor cells effectively. Significantly, acting as an antioxidant and anti‐inflammatory agent, Ti3C2‐BSA‐CQ4T‐H2 (TCBCH) protects peritumoral normal cells from damage. The proposed technique utilizing H2 gas for combination therapies and multimodal imaging integration exhibits prospects for effective and secure treatment of tumors in future clinical applications.This article is protected by copyright. All rights reserved

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Molecular hydrogen reduces acute exercise-induced inflammatory and oxidative stress status

Cited by 48 publications

References 77 publications

Application of Molecular Hydrogen as a Novel Antioxidant in Sports Science

Application of Molecular Hydrogen as a Novel Antioxidant in Sports Science

Professional Swimmers and Normal Populations have Different Patterns of Epidermal Green Autofluorescence

NIR‐II Absorption/Emission Dual Function Based 2D Targeted Nanotheranostics for Tunable Hydrogenothermal Therapy

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