Molecular Hydrogen Attenuated N-methyl-N-Nitrosourea Induced Corneal Endothelial Injury by Upregulating Anti-Apoptotic Pathway

Li, Runpu; Qu, Yingxin; Li, Xiaoqi; Tao, Ye; Yang, Qinghua; Wang, Junyi; Diao, Yutao; Li, Qian; Fang, Yifan; Huang, Yifei; Wang, Liqiang

doi:10.1167/iovs.62.9.2

Cited by 4 publications

(1 citation statement)

References 79 publications

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“…Another animal experiment also shows that H 2 dissolved in the ocular irrigating solution is protective against the against the endothelial cell damage caused by phacoemulsification in rabbit eyes [40]. Researchers have successfully established a corneal endothelium decompensation rabbit model [39]. They find that irrigating rabbit eyes with HRS can improve the survival and physiological function of corneal endothelial cells by inhibiting apoptotic cascades.…”

Section: The Potential Therapeutic Effects On Corneal Endothelial Dys...mentioning

confidence: 99%

Novel Role of Molecular Hydrogen: The End of Ophthalmic Diseases?

Li,

Xue,

et al. 2023

Pharmaceuticals

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Molecular hydrogen (H2) is a colorless, odorless, and tasteless gas which displays non-toxic features at high concentrations. H2 can alleviate oxidative damage, reduce inflammatory reactions and inhibit apoptosis cascades, thereby inducing protective and repairing effects on cells. H2 can be transported into the body in the form of H2 gas, hydrogen-rich water (HRW), hydrogen-rich saline (HRS) or H2 produced by intestinal bacteria. Accumulating evidence suggest that H2 is protective against multiple ophthalmic diseases, including cataracts, dry eye disease, diabetic retinopathy (DR) and other fields. In particular, H2 has been tested in the treatment of dry eye disease and corneal endothelial injury in clinical practice. This medical gas has brought hope to patients suffering from blindness. Although H2 has demonstrated promising therapeutic potentials and broad application prospects, further large-scale studies involving more patients are still needed to determine its optimal application mode and dosage. In this paper, we have reviewed the basic characteristics of H2, and its therapeutic effects in ophthalmic diseases. We also focus on the latest progress in the administration approaches and mechanisms underlying these benefits.

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Section: The Potential Therapeutic Effects On Corneal Endothelial Dys...mentioning

confidence: 99%