Molecular heterochrony in the early development of
            <i>Drosophila</i>

Kim, Junhyong; Kerr, Jonita Q.; Min, Gi–Sik

doi:10.1073/pnas.97.1.212

Cited by 47 publications

(38 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The genetic backgrounds of different taxa (Song et al, 2006) could thus provide the regulatory variation required for perturbations to gene expression patterns in hybrids, as has been documented in Drosophila (Kim et al, 2000). Furthermore, the adaptation of Boechera to multiple habitats (Kiefer et al, 2009) variation in life history traits in different populations, one aspect of which could be the timing of reproductive development.…”

Section: Heterochronic Gene Expression Is Characterized By a Global Smentioning

confidence: 99%

Apomictic and Sexual Ovules ofBoecheraDisplay Heterochronic Global Gene Expression Patterns

et al. 2010

View full text Add to dashboard Cite

We have compared the transcriptomic profiles of microdissected live ovules at four developmental stages between a diploid sexual and diploid apomictic Boechera. We sequenced >2 million SuperSAGE tags and identified (1) heterochronic tags (n = 595) that demonstrated significantly different patterns of expression between sexual and apomictic ovules across all developmental stages, (2) stage-specific tags (n = 577) that were found in a single developmental stage and differentially expressed between the sexual and apomictic ovules, and (3) sex-specific (n = 237) and apomixis-specific (n = 1106) tags that were found in all four developmental stages but in only one reproductive mode. Most heterochronic and stage-specific tags were significantly downregulated during early apomictic ovule development, and 110 were associated with reproduction. By contrast, most late stage-specific tags were upregulated in the apomictic ovules, likely the result of increased gene copy number in apomictic (hexaploid) versus sexual (triploid) endosperm or of parthenogenesis. Finally, we show that apomixisspecific gene expression is characterized by a significant overrepresentation of transcription factor activity. We hypothesize that apomeiosis is associated with global downregulation at the megaspore mother cell stage. As the diploid apomict analyzed here is an ancient hybrid, these data are consistent with the postulated link between hybridization and asexuality and provide a hypothesis for multiple evolutionary origins of apomixis in the genus Boechera.

show abstract

Section: Heterochronic Gene Expression Is Characterized By a Global Smentioning

confidence: 99%

Apomictic and Sexual Ovules ofBoecheraDisplay Heterochronic Global Gene Expression Patterns

et al. 2010

View full text Add to dashboard Cite

show abstract

“…More generally, how the transcriptome as a whole is affected by evolutionary shifts in developmental timing is an open question. Although studies in model organisms have previously documented how changes in gene expression timing during development can produce morphological and functional novelties (15,16), this type of evolutionary change has not yet been investigated on a genome-wide scale.…”

mentioning

confidence: 99%

Transcriptional neoteny in the human brain

Somel

Franz

Zheng

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

347

316

View full text Add to dashboard Cite

In development, timing is of the utmost importance, and the timing of developmental processes often changes as organisms evolve. In human evolution, developmental retardation, or neoteny, has been proposed as a possible mechanism that contributed to the rise of many human-specific features, including an increase in brain size and the emergence of human-specific cognitive traits. We analyzed mRNA expression in the prefrontal cortex of humans, chimpanzees, and rhesus macaques to determine whether human-specific neotenic changes are present at the gene expression level. We show that the brain transcriptome is dramatically remodeled during postnatal development and that developmental changes in the human brain are indeed delayed relative to other primates. This delay is not uniform across the human transcriptome but affects a specific subset of genes that play a potential role in neural development.human evolution ͉ brain development ͉ gene expression ͉ heterochrony ͉ chimpanzee

show abstract

“…It is important to understand how genetic variations affect development and are translated into morphological changes. It is well-established that morphological changes among and within species are ultimately determined by genetic interference during the developmental process because small changes during development can produce large changes in adult morphology (Kim et al, 2000;Raff, 2000). During the long process of dental development, complex interactions between genetic, epigenetic, and environmental factors cause dental anomalies, as demonstrated by Brook (2009).…”

Section: Discussionmentioning

confidence: 99%

Association of MSX1 and TGF-β1 genetic polymorphisms with hypodontia: meta-analysis

Zhang

2014

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. We conducted a comprehensive meta-analysis of 4 case-control studies to explore the association between polymorphisms of Msh homeobox 1 (MSX1) and transforming growth factor-β1 (TGF-β1) genes and hypodontia. A total of 643 tooth agenesis cases and 733 healthy controls were included in this study. The meta-analysis results showed that the T allele and T carrier (CT + TT) of rs1095 in the MSX1 gene were positively associated with hypodontia susceptibility. However, the T allele and T carrier (TC + CC) of rs12532 and rs8670 showed no association with cancer susceptibility. In addition, there were no strong associations between the T allele and T carrier (CT + TT) of C509T and the A allele and A carrier (AG + AA) of G800A in the TGF-β1 gene polymorphisms between patients with tooth agenesis and healthy subjects. In conclusion, these meta-analysis results demonstrated that polymorphisms in the rs1095 region of the MSX1 gene may influence the transcriptional activity of this gene and are associated with hypodontia in humans. However, the association between the TGF-β1 gene and sporadic tooth agenesis is not well understood, and further studies are required to explore the correlation between the TGF-β1 gene and hypodontia.

show abstract

Molecular heterochrony in the early development of Drosophila

Cited by 47 publications

References 47 publications

Apomictic and Sexual Ovules ofBoecheraDisplay Heterochronic Global Gene Expression Patterns

Apomictic and Sexual Ovules ofBoecheraDisplay Heterochronic Global Gene Expression Patterns

Transcriptional neoteny in the human brain

Association of MSX1 and TGF-β1 genetic polymorphisms with hypodontia: meta-analysis

Contact Info

Product

Resources

About