Molecular genetics of tooth development

Bei, Marianna

doi:10.1016/j.gde.2009.09.002

Cited by 189 publications

(166 citation statements)

References 43 publications

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“…Key signaling pathways including Bmp, Fgf, Notch, and Eda are impaired in the absence of p63 (Laurikkala et al 2006). The importance of the signaling that takes place at the placode stage is further highlighted by the phenotype of several mouse mutants where tooth development stops before epithelial budding (Bei 2009b).…”

Section: Signal Network and Signaling Centersmentioning

confidence: 99%

“…The deletion of the function of several of these either alone or together with another transcription factor in the same family results in tooth arrest at placode or bud stage. All four signal pathways have been shown to be involved in the regulation of these transcription factors (Bei 2009b). For example, Bmp4 induces the expression of Msx1 and Fgf8 induces the expression of Pax9 (Vainio et al 1993, Neubüser et al 1997).…”

Section: Signaling Network Regulating Tooth Developmentmentioning

confidence: 99%

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Signaling Networks Regulating Tooth Organogenesis and Regeneration, and the Specification of Dental Mesenchymal and Epithelial Cell Lineages

Jussila

Thesleff²

2012

Cold Spring Harbor Perspectives in Biology

225

209

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SUMMARYTeeth develop as ectodermal appendages from epithelial and mesenchymal tissues. Tooth organogenesis is regulated by an intricate network of cell -cell signaling during all steps of development. The dental hard tissues, dentin, enamel, and cementum, are formed by unique cell types whose differentiation is intimately linked with morphogenesis. During evolution the capacity for tooth replacement has been reduced in mammals, whereas teeth have acquired more complex shapes. Mammalian teeth contain stem cells but they may not provide a source for bioengineering of human teeth. Therefore it is likely that nondental cells will have to be reprogrammed for the purpose of clinical tooth regeneration. Obviously this will require understanding of the mechanisms of normal development. The signaling networks mediating the epithelial-mesenchymal interactions during morphogenesis are well characterized but the molecular signatures of the odontogenic tissues remain to be uncovered. Outline

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Section: Signal Network and Signaling Centersmentioning

confidence: 99%

Section: Signaling Network Regulating Tooth Developmentmentioning

confidence: 99%

Signaling Networks Regulating Tooth Organogenesis and Regeneration, and the Specification of Dental Mesenchymal and Epithelial Cell Lineages

Jussila

Thesleff²

2012

Cold Spring Harbor Perspectives in Biology

225

209

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“…These signaling pathways are part of a larger odontogenic signaling network involving genes that are absolutely necessary for tooth formation in man and mouse, such as the MSX1 transcription factor. 23,24,[66][67][68]69,70,71 …”

Section: Disclosure Of Potential Conflicts Of Interestmentioning

confidence: 99%

Integration of tooth morphogenesis and innervation by local tissue interactions, signaling networks, and semaphorin 3A

Luukko

Kettunen

2016

Cell Adhesion & Migration

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The tooth, like many other organs, develops from both epithelial and mesenchymal tissues, and has proven to be a valuable tool with which to investigate organ formation and peripheral innervation. Tooth formation is regulated by local epithelial-mesenchymal tissue interactions, and is closely integrated with stereotypic dental nerve navigation and patterning. Recent analyses of the function and regulation of semaphorin 3A (SEMA3A) have shed light on the regulatory mechanisms that coordinate organogenesis and innervation at the tissue and molecular levels. In the tooth, SEM3A acts as a developmentally regulated secretory chemo-repellent, that controls tooth innervation during embryonic and postnatal development. The tooth germ governs its own innervation by a combination of local tissue interactions and SEMA3A expression. SEMA3A signaling, in turn, is controlled by a number of conserved signaling effectors, including TGF-b superfamily members, FGF, and WNT; all function in embryo and organ development, and are essential for tooth histo-morphogenesis. Thus, SEMA3A driven axon guidance is integrated into key odontogenic signaling networks, establishing this protein as a critical molecular tether between 2 distinct developmental processes (morphogenesis and sensory innervation), both of which are required to obtain a functional tooth.

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“…2,[5][6][7] Studies of animal development have identified many genes participating in dental morphogenesis. [8][9][10][11] Additionally, studies on human genetic disorders have identified dysfunctional mutations on coding region of some genes that result in tooth malformation. 12,13 However, very few examples of genetic polymorphisms associated with common dental variations have been identified.…”

Section: Introductionmentioning

confidence: 99%

Effects of an Asian-specific nonsynonymous EDAR variant on multiple dental traits

et al. 2012

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Dental morphology is highly diverse among individuals and between human populations. Although it is thought that genetic factors mainly determine common dental variations, only a few such genetic factors have been identified. One study demonstrated that a nonsynonymous single-nucleotide polymorphism (370V/A, rs3827760) in the ectodysplasin A receptor gene (EDAR) is associated with shoveling and double-shoveling grades of upper first incisors and tooth crown size. Here, we examined the association of EDAR 370V/A with several dental characters in Korean and Japanese subjects. A meta-analysis that combined analyses of Korean and Japanese subjects revealed that the Asian-specific 370A allele is associated with an increase in the grades of shoveling and double shoveling, as previously found. We also showed a highly significant association between EDAR 370V/A genotype and crown size, especially mesiodistal diameters of anterior teeth. Moreover, we found that the 370A allele was associated with the presence of hypoconulids of lower second molars. These results indicated that the EDAR polymorphism is responsible, in part, for the Sinodonty and Sundadonty dichotomy in Asian populations, and clearly demonstrated that the EDAR polymorphism has pleiotropic effects on tooth morphology. As the 370A allele is known to be a most likely target of positive selection in Asian populations, some phenotypes associated with the variant may be 'hitchhiking phenotypes', while others may be actual targets of selection.

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Molecular genetics of tooth development

Cited by 189 publications

References 43 publications

Signaling Networks Regulating Tooth Organogenesis and Regeneration, and the Specification of Dental Mesenchymal and Epithelial Cell Lineages

Signaling Networks Regulating Tooth Organogenesis and Regeneration, and the Specification of Dental Mesenchymal and Epithelial Cell Lineages

Integration of tooth morphogenesis and innervation by local tissue interactions, signaling networks, and semaphorin 3A

Effects of an Asian-specific nonsynonymous EDAR variant on multiple dental traits

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