Molecular Genetic variability in the D-loop region for females with Breast Cancer and the effect of the Chemotherapy

Buniya, Harith K.; Hassoon, Athraa H.; Hameed, Almuthana Kh.

doi:10.5958/0974-360x.2018.00694.7

Cited by 1 publication

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“…As is widely recognised, the Polymerase Chain Reaction (PCR) has been employed in various medical domains pertaining to the identification of clinical pathogenesis associated with infectious diseases and other perilous genetic conditions, such as cancer. [24][25][26][27][28][29][30][31][32][33][34][35][36][37][38]…”

Section: Discussionmentioning

confidence: 99%

Detection of Cytomegalovirus in Patients with Inflammatory Bowel Diseases in Iraq

Ahmed Majeed

2023

JCD

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Inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), are chronic inflammatory disorders of the gastrointestinal tract caused by interactions between genetic, environmental, immunological, and microbial factors.Objective: To study the association of Cytomegalovirus in a sample of Iraqi patients with inflammatory bowel diseases Methodology: The study included 160 patients, of which, 80 were diagnosed with IBD by a specialist in gastroenterology and 80 were apparently healthy subjects. Stool samples were collected from all participants and were prepared for detection of CMV PP65 by ELISA. The molecular method (real-time PCR) was used to detect the DNA of each pathogen.Results: Twenty-five patients with IBD had a significantly high level (8.44 pg/ml) of CMV as compared to the control group. The results showed that there was no significant correlation between CMV PP65 and the signs and symptoms of IBD patients (smoking, UC severity, bloody diarrhoea, abdominal pain, biological therapy, behaviour, or CD location). CMV real-time copy quantity was significantly correlated with smoking, bloody diarrhoea, abdominal discomfort, and biological therapy, but not with UC extent, behaviour, or CD location, as determined by molecular real-time PCR. Conclusion:There is a possible role of CMV in the pathogenesis of IBD in patients in Iraq. The biological treatment given to patients with IBD seems to reduce the CMV level.

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Section: Discussionmentioning

confidence: 99%

Detection of Cytomegalovirus in Patients with Inflammatory Bowel Diseases in Iraq

Ahmed Majeed

2023

JCD

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Molecular Genetic variability in the D-loop region for females with Breast Cancer and the effect of the Chemotherapy

Cited by 1 publication

References 0 publications

Detection of Cytomegalovirus in Patients with Inflammatory Bowel Diseases in Iraq

Detection of Cytomegalovirus in Patients with Inflammatory Bowel Diseases in Iraq

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