Molecular Genetic Study of Dental Caries Susceptibility in Mice

Uematsu, Tsunemi; Shimizu, Kunihiko; Nakamura, Hitoshi; Asada, Yosinobu; Maeda, Takeyasu

doi:10.5466/ijoms.1.33

Cited by 2 publications

(2 citation statements)

References 26 publications

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“…The earliest and most convincing demonstration of a genetic contribution to caries came from breeding experiments in rats [5][6][7][8][9][10][11] . Previous studies have shown that mice models are powerful tools in the study of the genetic contribution to dental caries [12][13][14][15][16] .…”

Section: Introductionmentioning

confidence: 99%

A Volume Evaluation of Dental Caries in a Mouse with the Use of the Micro-CT Scan

Shimoda

Ohta

Mohideen

et al. 2008

J. Hard Tissue Biology.

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The purpose of this study is to develop a three-dimensional method of caries evaluation; once a method is established genetic variables can be altered in order to detect the gene(s) involved in the development of dental caries in mice. As dental caries has a three-dimensional nature to its course, the Micro-CT scan quantifies the volume of caries. Inbred Mice were used of known caries susceptibility-BALB/c mice. Mice were divided into the control and experimental group; later inoculated with Streptococcus mutans. The experimental group was fed a caries promoting diet and later caries volume was evaluated by use of the Micro-CT scan in both groups. There was a clear difference in tooth volume of mice infected for 7 weeks and 9 weeks, the Micro-CT scan indicated this evidently.

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Section: Introductionmentioning

confidence: 99%

A Volume Evaluation of Dental Caries in a Mouse with the Use of the Micro-CT Scan

Shimoda

Ohta

Mohideen

et al. 2008

J. Hard Tissue Biology.

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“…Genetic fact9rs affecting dental cmies in mice were examined using two inbred strains of mice, C57BL/6J and C3H/HeJ, and these genetic crosses were evaluated by means of inoculation 8 with Streptococcus nlutans (S.lnutans) serotype c. These reports demonstrated that some genes played important roles in caries progress. It was reported that one of he candidate genes controlling a genetic difference in dental caries promoting ability between C3H1HeJ and C57BL/6J may be located on mouse chromosome 2 or 17 using a DNA pooling method (12). Recently, it has been reported that the major gene(s) responsible for cmies susceptibility is located between markers D2Mit463 and D2Mit48, cOlTesponding to 13 cM and 71 cM from the centromere on chromosome 2, using Quantitative Trait Loci (QTL) analysis (13).…”

Section: Introductionmentioning

confidence: 99%

A Morphological Study of the First Molars in Mice with High or Low Caries Susceptibility

et al. 2004

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The purpose of this study was to investigate whether the lesion of incipient caries was associated with morphological differences between the molars of C3HJHeJ and C57BL/6J mice. The caries scores for C57BL/6J and C3HJHeJ at 35 days old were 3.8±2.5 and O±O (mean±SD), respectively. The caries scores for C57BL/6J and C3H/HeJ at 49 days old were 42.4±8.3 and 4.2±2.4 (mean±SD), respectively. There was a 10-fold difference between C57BL/6J and C3HJHeJ in terms of caries progress. Incipient caries then appeared at the second fissure of lower MI. The central region of the second fissure of lower Ml in C57BL/6J was deeper and rougher than the same region in C3HJHeJ. The Ca/P ratios of the fissure for C57BL/6J and C3HJHeJ were 1.69±O.27 and 1.71 ±0.25 (mean±SD), respectively. The total data showed no significant difference between C57BL/6J and C3HJHeJ.In conclusion, it was found that incipient caries appeared at the second fissure of lower MI. Moreover, it is suggested that the morphology of the fissure as well as the immune responses may be responsible for the dental caries caused by stagnation of bacterial plaque.

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Molecular Genetic Study of Dental Caries Susceptibility in Mice

Cited by 2 publications

References 26 publications

A Volume Evaluation of Dental Caries in a Mouse with the Use of the Micro-CT Scan

A Volume Evaluation of Dental Caries in a Mouse with the Use of the Micro-CT Scan

A Morphological Study of the First Molars in Mice with High or Low Caries Susceptibility

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