Molecular genetic studies of risk assessment in developing occupational allergic dermatoses

Personalized medicine as a basis for occupational diseases prevention

“…This will allow us to develop and recommend specific preventive measures -dispensary observation, application of appropriate screening and diagnostic methods for the early diagnosis and treatment of diseases. From the point of view of occupational medicine, this approach is also applicable for rational selection of candidates for the profession in order to reduce the risk of a number of occupational and work-related diseases (for example, occupational cancer) [6,7,12,28,29].…”

“…Despite the fact that today there are many occupational risk assessment models depending on the prevailing adverse industrial impact, most of them are in the plane of determining/predicting the «dose-effective-time» relationship between the influence of a harmful factor and occupational pathology. It should be noted that most experts agree that there is no unified occupational health risk assessment scheme, which dictates the need to improve the individual health risk assessment of workers in the framework of personalized medicine, taking into account the concepts of WHO, ILO and the principles of evidence based medicine [2,3,6,7,9].…”

“…Occupational safety and health have a strong basis for further development, using approaches at both the population and individual levels. If necessary, it is possible to switch from personalized medicine to personalization of the entire system of labor protection [1,5,7,22].…”

“…In this regard, currently, priority is given to the development of a personalized approach in occupational medicine in order to early detection, diagnostics, and prevention of the transition of a pathological process to a chronic form using the latest achievements of molecular biology, genetics, and information technology. The search for modern and affordable means of occupational and production-related pathology prevention, especially in the context of reforming the health care system in Ukraine gains ground [6][7][8][9][10][11].…”

“…This approach is also successfully used to identify risk groups for occupational pathology. For example, there are data from molecular genetic studies in occupational medicine on the relationship of certain genotypes (for example, XPD*Asn/Asn genotype) with the risk of bronchopulmonary pathology development in a population of workers who come into contact with industrial hazards (dust of primarily fibrogenic action), concerning molecular genetic features of the formation of occupational asthma [2,3,7,[15][16][17]. However, the development of methods for early diagnosis and prevention of diseases, including at the molecular genetic level is complicated when it comes to some multifactorial diseases that reflect the total influence of different genes and their interaction with environmental factors [1,9,14,[20][21][22][23].…”