Molecular genetic studies in Saudi population; identified variants from GWAS and meta-analysis in stroke

Alharbi, Khalid Khalaf; Khan, Imran Ali; Alotaibi, Mohammad Abdullah; Aloyaid, Abdullah Saud; Al-Basheer, Haifa Abdulaziz; Alghamdi, Naelah Abdullah; Al-Baradie, Raid Saleem; Alsulaiman, Abdulrahman M.

doi:10.1016/j.sjbs.2017.08.014

Cited by 4 publications

(1 citation statement)

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“…[24]. PAME is also believed to have anti-fibrotic [25], blood pressure control [26], neuroprotective [27], anti-inflammatory [28,29], anti microba [30,31], antioxidant potential in Rumex nervosus [32], Crinum defixum [33], Indoneesiella echioides [34] dan Glycine max (L.) Merr [35]. Palmitic acid can be used as a therapeutic target to ameliorate vascular dysfunction in experimentally obese and hypertensive individuals [26], and this compound too demonstrated to be a novel neuroprotective compound in cerebral ischemia [27].…”

Section: Resultsmentioning

confidence: 99%

Determination of Marker Compounds of Senna alata from different location in East Kalimantan, Indonesia

Salam,

Laksmita,

Fernandes

et al. 2023

IOP Conf. Ser.: Earth Environ. Sci.

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Senna alata is a plant used for medical purposes, and its leaves have an extended history of use as a traditional herbal medicine in Indonesia. S. alata is known to contain some components of biologically active compounds and also secondary metabolites. In fact, S. alata can grow well in various locations in Indonesia, location differences can lead to differences in compound content due to differences in environmental conditions such as soil, rainfall, light intensity, and humidity. Therefore, this study aimed to analyze marker compounds of S. alata plants origin from three different location in East Kalimantan, i.e Samarinda, Samboja, and Berau. This research was conducted to estimate the compounds contained in extracts by using GC-MS analysis, and to discover relationships between different variables by using Principal Component Analysis (PCA). There are variances in the yield of secondary metabolites according on where Senna alata is grown, specifically in the riverside Nyapa Indah region and the plains of Samarinda and Samboja. Based on GC-MS test results, Phytol was the main compound in S.alata in two areas, i.e. Samarinda and Samboja. Meanwhile, in Berau showed that 1,2-Benzenedicarboxylic acid, and mono (2-ethylhexyl) ester were the main components. However, S. alata leaf extracts could be used as a good quality raw material for pharmaceutical industries, such as a laxative agent.

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