Molecular forms of cholecystokinin in plasma from normal and gastrectomized human subjects following a fat meal

Lack of effect of the specific cholecystokinin receptor antagonist loxiglumide on cholecystokinin clearance from plasma in man.

“…It might therefore be argued that molecular forms of CCK other than the one infused are metabolised differently during loxiglumide administration. This hypothesis, however, is unlikely since plasma CCK levels during CCK-8s infusion are not augmented by CCK-receptor antagonists (Cantor et al, 1989;Schmidt et al, 1989), and since plasma levels of endogenously released CCK during bombesin infusion resulting in circulating molecular forms (Jansen & Lamers, 1983c), comparable with those released after a meal (Jansen & Lamers, 1987), also rapidly declined after cessation of the bombesin infusion, despite continuous administration of loxiglumide (Jansen et al, 1989a).…”

Effect of Equimolar Amounts of Long‐Chain Triglycerides and Medium‐Chain Triglycerides on Small‐Bowel Transit Time in Humans

“…Plasma cholecystokinin was determined by a sensitive and specific radioimmunoassay that used antibody Tan. 7,8 This antibody binds to all carboxy-terminal cholecystokinin peptides containing the sulfated tyrosyl region. The detection limit of the assay was 0.5 pmol per liter of plasma The intra-assay variation ranged from 4.6% to 11.5%, and the interassay variation ranged from 11.3% to 26.1%.8…”

Plasma cholecystokinin levels and gallbladder volumes after proctocolectomy with ileal pouch-anal anastomosis

“…Cholecystokinin was measured in plasma by a sensitive and specific radioim munoassay.231 24 The antibody used (T204) was raised in rabbit after the fourth immunization with albumincoupled crude porcine cholecystokinin and used in a fi nal dilution of 1:80,000. The antibody binds to all carboxy-terminal cholecystokinin peptides containing the sulfated tyrosyl region.…”