Molecular Evolution of Peste des Petits Ruminants Virus

Muniraju, Murali; Munir, Muhammad; Parthiban, AravindhBabu R.; Banyard, Ashley C.; Bao, Jingyue; Wang, Zhiliang; Ayebazibwe, Chrisostom; Ayelet, Gelagay; Harrak, Mehdi El; Mahapatra, Mana; Libeau, Geneviève; Batten, Carrie; Parida, Satya

doi:10.3201/eid2012.140684

Cited by 87 publications

(129 citation statements)

References 36 publications

Supporting

Mentioning

106

Contrasting

Unclassified

Order By: Relevance

“…Accordingly, the evolutionary rate of PPRV at the genomic scale was estimated to be 7.8 × 10 −4 nucleotide substitutions per site, per year (95% HPD values = 7.3–8.4 × 10 −4 subs/site/year) and the time to common ancestor of this sample of PPRV was estimated to be between 1891–1905 (95% HPD values). These rate and divergence time estimates are broadly similar to those estimated previously for PPRV (Muniraju et al., ; Padhi and Ma, ), although for our analysis we has used a larger number of full genome sequences which have become available since their publications. Similarly, the divergence time of the genotype II viruses (of which Benin/B1/1969 is the basal lineage) was estimated to be between 1960–1963, while Benin/10/2011 is estimated to have diverged from Ghana/2010 and SnDK/Senegal/2013 between 1996–1999.…”

Section: Resultssupporting

confidence: 66%

Peste Des Petits Ruminants in Benin: Persistence of a Single Virus Genotype in the Country for Over 42 Years

Adombi

Waqas

Dundon

et al. 2016

Transbound Emerg Dis

View full text Add to dashboard Cite

Peste des petits ruminants (PPR) is a contagious and often fatal disease affecting sheep and goats. Currently, it is endemic in Africa, the Middle and Near East, the Indian subcontinent and China. Understanding the molecular epidemiology and evolution of PPR virus (PPRV) can assist in the control of the transboundary spread of this economically important disease. We isolated PPRV from pathological and swab samples collected 42 years apart (1969 and 2011) in Benin, West Africa, and sequenced the full genome of two isolates (Benin/B1/1969 and Benin/10/2011). Phylogenetic analysis showed that all of the characterized isolates clustered within viral lineage II and that the 2011 isolates fell into two distinct subgroups. Comparison of the full genome sequences revealed a 95.3% identity at the nucleotide level, while at the protein level, the matrix protein was the most conserved between the two viruses with an identity of 99.7% and only one amino acid substitution over the 42-year sampling period. An analysis of specific amino acid residues of known or putative function did not identify any significant changes between the two viruses. A molecular clock analysis of complete PPRV genomes revealed that the lineage II viruses sampled here arose in the early 1960s and that these viruses have likely persisted in Benin since this time.

show abstract

Section: Resultssupporting

confidence: 66%

Peste Des Petits Ruminants in Benin: Persistence of a Single Virus Genotype in the Country for Over 42 Years

Adombi

Waqas

Dundon

et al. 2016

Transbound Emerg Dis

View full text Add to dashboard Cite

show abstract

“…To ensure that high passage number vaccine strain sequence data did not skew the results as has been previously demonstrated [39], these sequences were removed from the following analysis (n = 37) (India/Sungri 96: KJ867542, KF727981 and Nigeria 75 (X74443, HQ197753). The general time-reversible nucleotide substitution model with a gamma distribution for rate variation and proportion of invariant sites was selected on the basis of Akaike information criterion scores.…”

Section: Methodsmentioning

confidence: 99%

Peste des petits ruminants (PPR): A neglected tropical disease in Maghreb region of North Africa and its threat to Europe

et al. 2017

Self Cite

View full text Add to dashboard Cite

BackgroundPeste des petits ruminants (PPR) is a contagious disease listed by the World Organisation for Animal health (OIE) as being a specific hazard. It affects sheep, goats, and wild ungulates, and is prevalent throughout the developing world particularly Asia, the Middle East, and Africa. PPR has been targeted for eradication by 2030 by the Food and Agriculture Organization of the United Nations (FAO) and the OIE, after the successful eradication of the related disease, rinderpest in cattle. PPR was first reported in 1942 in the Ivory Coast in Western Africa and has since extended its range in Asia, the Middle East, and Africa posing an immediate threat of incursion into Europe, South East Asia and South Africa. Although robust vaccines are available, the use of these vaccines in a systematic and rational manner is not widespread, resulting in this devastating disease becoming an important neglected tropical disease in the developing world.MethodologyWe isolated and characterized the PPR virus from an outbreak in Cheraga, northern Algeria, during October 2015 by analyzing the partial N-gene sequence in comparison with other viruses from the Maghreb region. As well as sequencing the full length viral genome and performing real-time RT-PCR on clinical samples. Maximum-likelihood and Bayesian temporal and phylogeographic analyses were performed to assess the persistence and spread of PPRV circulation from Eastern Africa in the Maghreb region of North Africa.ConclusionsRecent PPR outbreaks in Cheraga, in the northern part of Algiers (October 2015) and North-West Morocco (June, 2015) highlight that PPRV has spread to the northern border of North Africa and may pose a threat of introduction to Europe. Phylogeographic analysis suggests that lineage IV PPRV has spread from Eastern Africa, most likely from the Sudan 2000 outbreak, into Northern Africa resulting in the 2008 Moroccan outbreak. Maximum-likelihood and Bayesian analysis shows that these North African viruses cluster closely together suggesting the existence of continual regional circulation. Considering the same virus is circulating in Algeria, Morocco and Tunisia, implementation of a common Maghreb PPR eradication strategy would be beneficial for the region.

show abstract

“…Peste des petits ruminant virus (PPRV) is a negative‐strand RNA virus, belongs to the genus Morbillivirus in the family Paramyxoviridae (Gibbs et al., ). Peste des petits ruminant was first described as an infection of sheep and goats in Cote‐d'Ivoire (Gargadennec and Lalanne, ), and since then, the virus has been confirmed across Africa, Asia and the European part of Turkey (Ozkul et al., ; Kwiatek et al., ; Banyard et al., ; Balamurugan et al., ; Anees et al., ; Muniraju et al., ; Soltan and Abd‐Eldaim, ; Wang et al., ). Peste des petits ruminant virus exists as a single serotype (Shaila et al., ) and on the basis of studying partial F and N gene sequences; PPR viruses are classified into four lineages (I, II, III and IV) that differ genetically (Ozkul et al., ; Kwiatek et al., ).…”

Section: Introductionmentioning

confidence: 99%

Detection and Genetic Characterization of Lineage IV Peste Des Petits Ruminant Virus in Kazakhstan

Kock

Orynbayev

Sultankulova

et al. 2015

Transbound Emerg Dis

View full text Add to dashboard Cite

Peste des petits ruminant (PPR) is endemic in many Asian countries with expansion of the range in recent years including across China during 2013-2014 (OIE, 2014). Till the end of 2014, no cases of PPR virus (PPRV) were officially reported to the Office Internationale des Epizooties (OIE) from Kazakhstan. This study describes for the first time clinicopathological, epidemiological and genetic characterization of PPRV in 3 farm level outbreaks reported for the first time in Zhambyl region (oblast), southern Kazakhstan. Phylogenetic analysis based on partial N gene sequence data confirms the lineage IV PPRV circulation, similar to the virus that recently circulated in China. The isolated viruses are 99.5-99.7% identical to the PPRV isolated in 2014 from Heilongjiang Province in China and therefore providing evidence of transboundary spread of PPRV. There is a risk of further maintenance of virus in young stock despite vaccination of adult sheep and goats, along livestock trade and pastoral routes, threatening both small livestock and endangered susceptible wildlife populations throughout Kazakhstan.

show abstract

Molecular Evolution of Peste des Petits Ruminants Virus

Abstract: Sequence data will increase understanding of virus evolution, adaptability, and pathogenicity.

Cited by 87 publications

References 36 publications

Peste Des Petits Ruminants in Benin: Persistence of a Single Virus Genotype in the Country for Over 42 Years

Peste Des Petits Ruminants in Benin: Persistence of a Single Virus Genotype in the Country for Over 42 Years

Peste des petits ruminants (PPR): A neglected tropical disease in Maghreb region of North Africa and its threat to Europe

Detection and Genetic Characterization of Lineage IV Peste Des Petits Ruminant Virus in Kazakhstan

Contact Info

Product

Resources

About