Molecular evolution of haemagglutinin (H) gene in measles virus

Kimura, Hirokazu; Saitoh, Masaaki; Kobayashi, Miho; Ishii, Haruyuki; Saraya, Takeshi; Kurai, Daisuke; Tsukagoshi, Hiroyuki; Shirabe, Komei; Nishina, Atsuyoshi; Kozawa, Kunihisa; Kuroda, Makoto; Takeuchi, Fumihiko; Sekizuka, Tsuyoshi; Minakami, Hisanori; Ryo, Akihide; Takeda, Makoto

doi:10.1038/srep11648

Cited by 36 publications

(30 citation statements)

References 37 publications

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“…The model with the lowest AICM value was selected to be the best-fit model in each sequence dataset and used for analysis (Kimura et al, 2015;Nagasawa et al, 2015) (Supplementary Table 1).…”

Section: Carlo (Mcmc) and Maximum Likelihood (Ml) Methodsmentioning

confidence: 99%

“…To assess the time course trend of effective population size (EPS) of overall RSV-A strains circulating in central Vietnam during the investigation period, Bayesian Skyline Plot (BSP) was constructed using BEAST ver.1.8.0 as previously described (Drummond and Rambaut, 2007;Kimura et al, 2015;Nagasawa et al, 2015). KAKUSAN4 was used for the selection of best-fit nucleotide substitution model.…”

Section: Bayesian Skyline Plot (Bsp) Analysismentioning

confidence: 99%

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Molecular evolution of respiratory syncytial virus subgroup A genotype NA1 and ON1 attachment glycoprotein ( G ) gene in central Vietnam

Yoshihara

Nagasawa

et al. 2016

Infection, Genetics and Evolution

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We performed molecular evolutionary analyses of the G gene C-terminal 3rd hypervariable region of RSV-A genotypes NA1 and ON1 strains from the paediatric acute respiratory infection patients in central Vietnam during the 2010-2012 study period. Time-scaled phylogenetic analyses were performed using Bayesian Markov Chain Monte Carlo (MCMC) method, and pairwise distances (p-distances) were calculated. Bayesian Skyline Plot (BSP) was constructed to analyze the time-trend relative genetic diversity of central Vietnam RSV-A strains. We also estimated the N-glycosylation sites within G gene hypervariable region. Amino acid substitutions under positive and negative selection pressure were examined using Conservative Single Likelihood Ancestor Counting (SLAC), Fixed Effects Likelihood (FEL), Internal Fixed Effects Likelihood (IFEL) and Mixed Effects Model for Episodic Diversifying Selection (MEME) models. The majority of central Vietnam ON1 strains detected in 2012 were classified into lineage 1 with few positively selected substitutions. As for the Vietnamese NA1 strains, four lineages were circulating during the study period with a few positive selection sites. Shifting patterns of the predominantly circulating NA1 lineage were observed in each year during the investigation period. Median p-distance of central Vietnam NA1 strains was wider (p-distance = 0.028) than that of ON1 (p-distance = 0.012). The molecular evolutionary rate of central Vietnam ON1 strains was estimated to be 2.55 × 10-2 (substitutions/site/year) and was faster than NA1 (7.12 × 10-3 (substitutions/site/year)). Interestingly, the evolutionary rates of both genotypes ON1 and NA1 strains from central Vietnam were faster than the global strains respectively. Furthermore, the shifts of N-glycosylation pattern within the G gene 3rd hypervariable region of Vietnamese NA1 strains were observed in each year. BSP analysis indicated the rapid growth of RSV-A effective population size in early 2012. These results suggested that the molecular evolution of RSV-A G gene detected in central Vietnam was fast with unique evolutionary dynamics.

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Section: Carlo (Mcmc) and Maximum Likelihood (Ml) Methodsmentioning

confidence: 99%

Section: Bayesian Skyline Plot (Bsp) Analysismentioning

confidence: 99%

Molecular evolution of respiratory syncytial virus subgroup A genotype NA1 and ON1 attachment glycoprotein ( G ) gene in central Vietnam

Yoshihara

Nagasawa

et al. 2016

Infection, Genetics and Evolution

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“…To date, 24 MeV genotypes are recognized with preferential geographic circulation. A Bayesian skyline plot analysis suggested that prevalent genotypes such as genotype D4 are more adaptive to humans (61). The fact that most of the subgenotype D4.1 sequences that we retrieved from GenBank were derived from Kenya and Ethiopia, whereas the MAb-resistant subgenotype D4.2 MeV sequences were derived predominantly from France and Great Britain, might suggest that an intermediary level of vaccine coverage provides an environment more prone to adaptive mutations.…”

Section: New D4 Subgenotype Of Measles Virusmentioning

confidence: 99%

Antigenic Drift Defines a New D4 Subgenotype of Measles Virus

Muñoz-Alía

Russell

2017

J Virol

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The measles virus hemagglutinin (MeV-H) protein is the main target of protective neutralizing antibodies. Using a panel of monoclonal antibodies (MAbs) that recognize known major antigenic sites in MeV-H, we identified a D4 genotype variant that escapes neutralization by MAbs targeting the neutralizing epitope (NE) antigenic site. By site-directed mutagenesis, L249P was identified as the critical mutation disrupting the NE in this genotype D4 variant. Forty-two available D4 genotype gene sequences were subsequently analyzed and divided into 2 groups according to the presence or absence of the L249P MeV-H mutation. Further analysis of the MeV-N gene sequences of these 2 groups confirmed that they represent clearly definable, sequence-divergent D4 subgenotypes, which we named subgenotypes D4.1 and D4.2. The subgenotype D4.1 MeVs were isolated predominantly in Kenya and Ethiopia, whereas the MAb-resistant subgenotype D4.2 MeVs were isolated predominantly in France and Great Britain, countries with higher vaccine coverage rates. Interestingly, D4.2 subgenotype viruses showed a trend toward diminished susceptibility to neutralization by human sera pooled from approximately 60 to 80 North American donors. Escape from MAb neutralization may be a powerful epidemiological surveillance tool to monitor the evolution of new MeV subgenotypes.IMPORTANCE Measles virus is a paradigmatic RNA virus, as the antigenic composition of the vaccination has not needed to be updated since its discovery. The vaccine confers protection by inducing neutralizing antibodies that interfere with the function of the hemagglutinin protein. Viral strains are indistinguishable serologically, although characteristic nucleotide sequences differentiate 24 genotypes. In this work, we describe a distant evolutionary branch within genotype D4. Designated subgenotype D4.2, this virus is distinguishable by neutralization with vaccine-induced monoclonal antibodies that target the neutralizing epitope (NE). The subgenotype D4.2 viruses have a higher predominance in countries with intermediary levels of vaccine coverage. Our studies demonstrate that subgenotype D4.2 lacks epitopes associated with half of the known antigenic sites, which significantly impacts our understanding of measles virus evolution.KEYWORDS virus evolution, antibody-mediated neutralization, antigenic variation, measles virus hemagglutinin, viral epitopes, measles virus genotypes, immune evasion M easles ranks as one of the most deadly diseases in the history of humankind (1, 2). The advent of an effective measles virus (MeV) vaccine 46 years ago dramatically reduced the number of measles deaths (3), making the MeV live-attenuated vaccine one of the most successful public health interventions ever undertaken (4, 5). Nonetheless, measles is still a leading cause of death globally for children younger than 5 years of age and was responsible for 134,200 deaths in 2015 (6). All 194 WHO member states have committed to reducing measles deaths, and the Global Measles and Rubella

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“…However, the fact linked with viruses and hosts which caused the divergence or convergence in the phylogenetic trees remained unclear. Two studies showed that the rate of variation of PPRV HN gene is higher than that of the MV H gene (66,81). In addition, the variation of PPRVHN gene is faster than that of the genome, which may be the result of the ability of PPRV HN to adapt to large host immune pressure.…”

Section: Mechanisms For Peste Des Petits Ruminants Virus Interspeciesmentioning

confidence: 99%

Expanding Diversity of Susceptible Hosts in Peste Des Petits Ruminants Virus Infection and Its Potential Mechanism Beyond

et al. 2020

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Peste des petits ruminants (PPR) is a severe respiratory and digestive tract disease of domestic small ruminants caused by PPR virus (PPRV) of the genus Morbillivirus. Although the primary hosts of PPRV are goats and sheep, the host range of PPRV has been continuously expanding and reported to infect various animal hosts over the last decades, which could bring a potential challenge to effectively control and eradicate PPR globally. In this review, we focused on current knowledge about host expansion and interspecies infection of PPRV and discussed the potential mechanisms involved.

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Molecular evolution of haemagglutinin (H) gene in measles virus

Cited by 36 publications

References 37 publications

Molecular evolution of respiratory syncytial virus subgroup A genotype NA1 and ON1 attachment glycoprotein ( G ) gene in central Vietnam

Molecular evolution of respiratory syncytial virus subgroup A genotype NA1 and ON1 attachment glycoprotein ( G ) gene in central Vietnam

Antigenic Drift Defines a New D4 Subgenotype of Measles Virus

Expanding Diversity of Susceptible Hosts in Peste Des Petits Ruminants Virus Infection and Its Potential Mechanism Beyond

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