Molecular evolution analysis of three species gyroviruses in China from 2018 to 2019

Development of a DAS–ELISA for Gyrovirus Homsa1 Prevalence Survey in Chickens and Wild Birds in China

“…Importantly, GyH1 co–infection with CAV leads to higher mortality and more widespread lymphocyte apoptosis [ 19 ], which increases the risk posed and makes prevention and control more difficult. Specifically, epidemiology investigation suggests that GyH1 is widespread in China, which is consistent with our findings [ 17 , 18 , 20 ]. Thus, an accurate diagnosis of GyH1 is particularly important.…”

“…We found that the highest positive rate of GyH1 occurred in 2019, which may be because after the pathogenicity of GyH1 attracted widespread attention, breeders stepped up preventive measures to reduce the infection rate [ 14 ]. Furthermore, the molecular epidemiological and seroepidemiological results further confirm our conclusions [ 18 , 20 ].…”

“…Ubiquitous gyroviruses make chickens in confinement vulnerable to the virus [ 17 ]. Moreover, the same host will likely be infected with multiple gyroviruses [ 18 ]. Co–infection of GyH1 with other gyroviruses, e.g., gyrovirus galga1 (GyG1) and CAV, occurs frequently.…”

“…Recombination in different viral genomes or within viral genomes is thought to be a major driver of viral evolution [ 21 ]. Previous studies have not found the recombination of GyH1 with other viruses [ 18 ]. Furthermore, GyH1 consists of three major proteins, the capsid protein VP1, the backbone protein VP2, and the apoptosis protein VP3.…”

Prevalence and phylogenetic analysis of Gyrovirus galga 1 in southern China from 2020 to 2022

“…GyVg1 is a newly discovered gyroviruses in 2011, and has subsequently been found successively in major poultry farming countries all over the world ( Sauvage et al, 2011 ; Chu et al, 2012 ; Dos et al, 2012 ; Maggi et al, 2012 ; Biagini et al, 2013 ; Smuts, 2014 ; Ji et al, 2022 ; Liu et al, 2022 ; Mase et al, 2022 ; Yan et al, 2023 ). The virus has not only been found in the brain tissues of chickens with neurological symptoms, but also has been detected in the blood of organ transplant recipients and AIDS patients, the feces of diarrhea patients, and even in the skin swabs and serum samples of healthy people, which makes it a zoonotic disease and a potential hidden danger to public health safety ( Rijsewijk et al, 2011 ; Sauvage et al, 2011 ; Chu et al, 2012 ; Maggi et al, 2012 ; Biagini et al, 2013 ; Gia et al, 2013 ; Feher et al, 2014 ; Ye et al, 2015 ).…”