Molecular evidence of tuberculosis induced hypertrophic osteopathy in a 16th-century Iroquoian dog

Bathurst, Rhonda R.; Barta, Jodi Lynn

doi:10.1016/j.jas.2003.12.006

Cited by 30 publications

(23 citation statements)

References 21 publications

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“…Previous research suggests that this particular dog suffered from HPO most likely linked to a M. tuberculosis infection (Bathurst & Barta, 2004).…”

Section: Methodsmentioning

confidence: 82%

“…Confirmation and expansion of an original macroscopic and molecular diagnosis for tuberculosis (TB) induced HPO (Bathurst & Barta, 2004) was accomplished using microscopic techniques on a 16 th -century Iroquoian canid metacarpal bone. The advanced information obtained in this study provides an avenue for discussion concerning the similarities in skeletal manifestations that humans and other mammals share in response to certain diseases.…”

Section: Introductionmentioning

confidence: 99%

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Using microscopy to improve a diagnosis: an isolated case of tuberculosis‐induced hypertrophic osteopathy in archaeological dog remains

Hunnius

2008

Intl J of Osteoarchaeology

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The use of histology to estimate age, understand taphonomic history and diagnose disease in human skeletal and mummified remains is a well-known method. Even though non-human animals experience stress and disease similar to humans, microscopy is rarely applied to faunal remains to obtain a diagnosis. Histological results from a 16 th -century Iroquoian dog which had previously been diagnosed by macroscopic and molecular methods with tuberculosis-induced hypertrophic osteopathy (HPO) are presented here. Comparisons indicate that canid microscopic skeletal manifestations of HPO are reminiscent of human alterations caused by this condition. In addition, the microscopy reveals an aggressive form of HPO that was chronic in nature which could not be identified by either macroscopic or molecular methods. By providing an extension to the original diagnosis, the impact of a chronic case of tuberculosis is discussed. This study helps to emphasise the utility of palaeohistopathology in both biological anthropology and zooarchaeology, as it allows for a deeper discussion of the manifestation of HPO and the impact of tuberculosis on both dogs and humans.

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“…Previous research suggests that this particular dog suffered from HPO most likely linked to a M. tuberculosis infection (Bathurst & Barta, 2004).…”

Section: Methodsmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Using microscopy to improve a diagnosis: an isolated case of tuberculosis‐induced hypertrophic osteopathy in archaeological dog remains

Hunnius

2008

Intl J of Osteoarchaeology

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“…Tuberculosis appears to be singular in this respect, in that there is a growing body of papers which report recovery of tuberculosis DNA from human and animal remains (2,11). This can in part be explained by the readily identified nature of skeletal lesions and by the extremely robust character of the mycobacterial cell wall (25).…”

Section: Discussionmentioning

confidence: 99%

Genotypic Analysis of the Earliest Known Prehistoric Case of Tuberculosis in Britain

2005

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The earliest known case of human tuberculosis in Britain dates to the middle period of the Iron Age, approximately 2,200 years before present. Bone lesions on the spine of a male skeleton excavated at Tarrant Hinton in Dorset, United Kingdom, show evidence of Pott's disease and are supported by molecular evidence of Mycobacterium tuberculosis complex DNA amplified by IS6110 PCR (19). In the present study, we used a further series of sensitive PCR methods to confirm the diagnosis of tuberculosis and to determine the genotype of the infecting strain. These tests demonstrated that this individual was infected with a strain of M. tuberculosis rather than Mycobacterium bovis. The strain had undergone the tuberculosis D1 deletion affecting the mmpS6 and mmpL6 genes and can therefore be identified as a member of the family of "modern" M. tuberculosis isolates. All evidence obtained was consistent with surviving mycobacterial DNA being highly fragmented in this case.

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“…The growth of this field of paleomicrobiology is summarized in Table 1 for ancient tuberculosis [4,5,9,10,[22][23][24][25][26][27][28][29][30][31][32][33] and in Table 2 for ancient leprosy [6,11,14,18,[34][35][36][37][38][39][40], highlighting the changes in methodology over time. Detailed information for a range of studies on ancient tuberculosis is provided in Table S1 [4,5,9,10,[22][23][24][25][26][27][28][29][30][31][32][33]36,.…”

Section: Introductionmentioning

confidence: 99%

“…Detailed information for a range of studies on ancient tuberculosis is provided in Table S1 [4,5,9,10,[22][23][24][25][26][27][28][29][30][31][32][33]36,. Similarly, studies on ancient leprosy are tabulated in Table S2 [6,[11][12][13][14]18,20,[34][35][36][37][38][39][40]53,[68][69][70][71][72][73][74][75][76].…”

Section: Introductionmentioning

confidence: 99%

Positive Diagnosis of Ancient Leprosy and Tuberculosis Using Ancient DNA and Lipid Biomarkers

et al. 2017

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Diagnosis of leprosy and tuberculosis in archaeological material is most informative when based upon entire genomes. Ancient DNA (aDNA) is often degraded but amplification of specific fragments also provides reliable diagnoses. Cell wall lipid biomarkers can distinguish ancient leprosy from tuberculosis and DNA extraction residues can be utilized. The diagnostic power of combined aDNA and lipid biomarkers is illustrated by key cases of ancient leprosy and/or tuberculosis. Human tuberculosis was demonstrated in a woman and child from Atlit-Yam (~9 ka) in the Eastern Mediterranean and in the 600 BCE Egyptian "Granville" mummy. Both aDNA and lipids confirmed Pleistocene tuberculosis in a~17 ka bison from Natural Trap Cave, Wyoming. Leprosy is exemplified by cases from Winchester (10th-12th centuries CE) and Great Chesterford (5th-6th centuries CE). A mixed infection from Kiskundorozsma, Hungary (7th century CE) allowed lipid biomarkers to assess the relative load of leprosy and tuberculosis. Essential protocols for aDNA amplification and analysis of mycolic, mycolipenic, mycocerosic acid, and phthiocerol lipid biomarkers are summarized. Diagnoses of ancient mycobacterial disease can be extended beyond the reach of whole genomics by combinations of aDNA amplification and lipid biomarkers, with sole use of the latter having the potential to recognize even older cases.

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Molecular evidence of tuberculosis induced hypertrophic osteopathy in a 16th-century Iroquoian dog

Cited by 30 publications

References 21 publications

Using microscopy to improve a diagnosis: an isolated case of tuberculosis‐induced hypertrophic osteopathy in archaeological dog remains

Using microscopy to improve a diagnosis: an isolated case of tuberculosis‐induced hypertrophic osteopathy in archaeological dog remains

Genotypic Analysis of the Earliest Known Prehistoric Case of Tuberculosis in Britain

Positive Diagnosis of Ancient Leprosy and Tuberculosis Using Ancient DNA and Lipid Biomarkers

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