Molecular evidence for the anamorph—teleomorph connection in Cordyceps sinensis

Zuo-yi, Liu; Yao, Yi‐Jian; Liang, Z.; Liú, Àiyīng; Pegler, D.N.; Chase, Mark W.

doi:10.1017/s095375620100377x

Cited by 74 publications

(85 citation statements)

References 10 publications

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“…One group of taxa consisting of Cordyceps multiaxialis, C. nepalensis, C. sinensis and Hirsutella sinensis, was recognized (subclade IV-G), of which the two former were described recently from alpine areas of China and Nepal (Zang & Kinjo 1998). The conclusion of Liu et al (2001c) that C. multiaxialis and C. nepalensis are synonyms of C. sinensis, is not contradicted by the level of ITS divergence observed among these taxa in our study. Here, the long branch of C. sinensis is largely due to a number of unique CpT transitions, of which several were located in the conserved 5.8S gene.…”

Section: Discussionsupporting

confidence: 48%

“…Paecilomyces sinensis (Chen, Xiao & Shi 1984), Synnematium sinense (Yin & Shen 1990) and Chrysosporium sinense (Liang 1991a). An anamorph-teleomorph connection between Hirsutella sinensis and Cordyceps sinensis was suggested by Liu et al (1989) and has later been confirmed by others (Zhao et al 1999, Li, Huang & Fan 2000, Chen et al 2001, Liu et al 2001c). …”

Section: Discussionmentioning

confidence: 73%

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Towards a phylogenetic classification of Cordyceps: ITS nrDNA sequence data confirm divergent lineages and paraphyly

Stensrud

Hywel‐Jones

Schumacher

2005

Mycological Research

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The ascomycetous genus Cordyceps accommodates endoparasitic species that attack arthropods or other fungi. Analyses of ITS nrDNA sequence data of 72 taxa from the teleomorph genera Cordyceps, Claviceps, Epichloe¨, and the anamorph genera Akanthomyces, Beauveria, Metarhizium, Hirsutella, Hymenostilbe, Paecilomyces, Polycephalomyces, and Tolypocladium assigned the taxa to four main evolutionary lineages not reflected in the current classification of Cordyceps. Ten subclades were recognized from separate analyses of data subsets. Judged from the ITS phylogenies, Cordyceps spp. with branched stromata were highly supported as a divergent lineage. Host specificity was found to be of limited phylogenetic significance, and several host shifts are suggested to have occurred during the evolution of Cordyceps. Similar ascospore morphology was not reflected in the phyletic groups, and closely related taxa showed large interspecific variation with respect to the number of segments in which the ascospores are divided. However, combinations of selected characters were found to delimitate some lineages, e.g. all Cordyceps spp. that attack hosts in the insect orders Coleoptera and Lepidoptera, and with non-immersed perithecia and clavate to acicular, brightly yellowish to reddish stromata, constituted a separate clade. Furthermore, all Cordyceps spp. with perithecia obliquely immersed in the stroma were recognized as a distinct monophyletic group. This clade is additionally characterized by the formation of anamorphs ascribable to the genus Hymenostilbe. The mycogenous Cordyceps spp. grouped in a separate subclade, interspersed by two cicadaen parasites and all Tolypocladium spp. except T. parasiticum. Tolypocladium and Beauveria were found to be polyphyletic. The included Claviceps and Epichloe¨taxa appeared to be derived within Cordyceps, thus making Cordyceps paraphyletic as suggested in other studies.

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Section: Discussionsupporting

confidence: 48%

Section: Discussionmentioning

confidence: 73%

Towards a phylogenetic classification of Cordyceps: ITS nrDNA sequence data confirm divergent lineages and paraphyly

Stensrud

Hywel‐Jones

Schumacher

2005

Mycological Research

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“…Although P. hepiali was isolated from Chinese cordyceps in 1982 and described as the anamorph of O. sinensis (Dai et al 1989), it was invalidly published and H. sinensis was described and validly published later (Liu et al 1989). H. sinensis is generally accepted by mycologists as the anamorph of O. sinensis and the notion is also supported by DNA sequence analyses by Zhao et al (1999), Chen et al (2001) and Liu et al (2001, 2002) and RAPD experiments by Li et al (2000). H. sinensis has been large-scale fermented and developed into medicinal products such as Corbrin capsule, tablets and granulation.…”

Section: The Chinese Cordyceps Industrymentioning

confidence: 88%

Cordyceps industry in China

Dong

Guo²,

Wang

et al. 2015

Mycology

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Cordyceps, as a general term, describes a group of ascomycetous fungi growing on arthropods and other related fungi. Some cordyceps have been used in traditional Chinese medicine for centuries and cordyceps-derived products are currently a big industry in China. A number of medicinal and health products have been developed and extensively commercialized from natural Chinese cordyceps, its anamorphic fungus (Hirsutella sinensis), and other fungi known as Chinese cordyceps. The lack of a defined classification system for medicinal cordyceps fungi is a source of confusion in the industry and the public, and even among pharmaceutical scientists. This review summarizes the cordyceps fungi currently used in the industry in China with a special reference to clarify Chinese cordyceps and associated fungi. Cordyceps militaris, Cordyceps guangdongensis and Isaria cicadae are well recognized and commercialized cordyceps fungi in China. Except the natural Chinese cordyceps and its anamorphic fungus, Paecilomyces hepiali, Mortierella hepiali, Cephalosporium sinensis and Clonostachys rosea isolated from natural Chinese cordyceps are classified as Chinese cordyceps–associated fungi. P. hepiali is a cordyceps fungus based on current phylogenetic analysis of Hypocreales, while M. hepiali is a fungus in the Zygomycetes and should only be treated as associated fungus of Chinese cordyceps. C. sinensis and C. rosea belong to the Hypocreales and their relationship to cordyceps fungi should be further studied. The exploitation of the resources of cordyceps fungi and their quality control in the industry should be major topics for future studies. Cooperation between the industry and the research community will enhance the whole cordyceps industry.

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“…The strain used in this research was Hirsutella sinensis, which was identified as the anamorph of Ophiocordyceps sinensis [12,13]. 0. .…”

Section: Fungus and Mycelia Fermentationmentioning

confidence: 99%

“…20 mg HSP-1 was dried under vacuum over P 2 O 5 for several days and then put it into a 5-mm Nuclear Magnetic Resonance (NMR) tube with 1 mL of D 2 O. NMR ( 1 H, 13 C) spectra were accomplished with a Bruker 400 spectrometer.…”

Section: Nmr Spectroscopymentioning

confidence: 99%

Structural Elucidation and Antioxidant Activity of a Polysaccharide from Mycelia Fermentation of Hirsutella sinensis Isolated from Ophiocordyceps sinensis

Wang¹

2014

J Bioproces Biotech

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Molecular evidence for the anamorph—teleomorph connection in Cordyceps sinensis

Cited by 74 publications

References 10 publications

Towards a phylogenetic classification of Cordyceps: ITS nrDNA sequence data confirm divergent lineages and paraphyly

Towards a phylogenetic classification of Cordyceps: ITS nrDNA sequence data confirm divergent lineages and paraphyly

Cordyceps industry in China

Structural Elucidation and Antioxidant Activity of a Polysaccharide from Mycelia Fermentation of Hirsutella sinensis Isolated from Ophiocordyceps sinensis

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