Molecular Events Towards Wnt Pathway Activation in Cervical Cancer: Changing the Balance on NKD/DVL Signals

Abstract

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A Review of the Molecular Pathways of Oncogenic HPV and Targeted the Rapies in Carcinoma of the Uterine Cervix

“…The Wnt/beta-catenin pathway activation has been shown to be necessary to induce the transformation of HPV immortalization [28]. The activation of beta-catenin by the inactivation of negative regulators such as APC through methylation, or by the overexpression of activators such as Wnt ligands, frizzled receptors (Dvl), inhibits GSK3beta and causes the accumulation of beta-catenin in the cytoplasm and then the nucleus where it forms an active transcriptional complex with T-cell factor, which then activates the transcription of target genes including c-myc and cyclin D [4].…”